Limosilactobacillus reuteri regulates gut microbiota and increases the effective metabolite luteolin to inhibit MAPK/STAT3 signaling pathway to alleviate allergic rhinitis DOI Creative Commons
Mingyan Zhang,

Xuewei Sun,

Xiang Yu

et al.

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 24, 2025

The global prevalence of allergic rhinitis (AR) remains high, posing challenges due to its chronic nature and propensity for recurrence. Gut microbiota dysbiosis contributes immune dysregulation, impacting AR pathogenesis. Limosilactobacillus reuteri (L. reuteri) has great potential in regulating function alleviate symptoms. However, the specific active components mechanisms underlying therapeutic effects remain incompletely clarified. This study aimed explore L. metabolites alleviating AR. mouse model was constructed using ovalbumin (OVA). analysis hematoxylin-eosin staining (HE staining) enzyme-linked immunosorbent assay (ELISA) suggested that alleviated nasal inflammation, suppressed aberrant Th2 responses, modulated balance Treg Th17 cytokines. 16S rRNA sequencing untargeted metabolic revealed restored gut composition significantly increased abundance Ligilactobacillus metabolite luteolin (LO). Through ELISA Western blotting analysis, LO treatment Th1/Th2 Treg/Th17 cytokine MAPK/STAT3 signaling pathway mice. highlights as a key contributing anti-inflammatory reuteri, suggesting avenues future strategies management.

Language: Английский

The Relationship between Fine Particle Matter (PM2.5) Exposure and Upper Respiratory Tract Diseases DOI Open Access
Łukasz Zaręba, Katarzyna Piszczatowska, Karolina Dżaman

et al.

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(1), P. 98 - 98

Published: Jan. 16, 2024

PM2.5 is one of the most harmful components airborne pollution and includes particles with diameters less than 2.5 μm. Almost 90% world's population lives in areas poor air quality exceeding norms established by WHO. exposure affects various organs systems human body including upper respiratory tract which prone to its adverse effects. can disrupt nasal epithelial cell metabolism, decrease integrity barrier, affect mucociliary clearance, alter inflammatory process mucosa. Those effects may increase chance developing diseases high pollution. PM2.5's contribution allergic rhinitis (AR) rhinosinusitis was recently thoroughly investigated. Numerous studies demonstrated mechanisms that occur when subjects AR or are exposed PM2.5. Various immunological changes alterations sinonasal epithelia were reported. These contribute observations higher concentrations symptoms patients number clinical visits. Thus, studying novel strategies against has become focus researchers' attention. In this review, we summarize current knowledge on healthy mucosa rhinosinusitis. Finally, advances particles' tract.

Language: Английский

Citations

16
Molecular Aspects of Allergens and Allergy DOI
Rudolf Valenta, А. В. Караулов,

Verena Niederberger

et al.

Advances in immunology, Journal Year: 2018, Volume and Issue: unknown, P. 195 - 256

Published: Jan. 1, 2018

Language: Английский

Citations

118
Modulation of Allergic Inflammation in the Nasal Mucosa of Allergic Rhinitis Sufferers With Topical Pharmaceutical Agents DOI Creative Commons

Annabelle M. Watts,

Allan W. Cripps, Nicholas P. West

et al.

Frontiers in Pharmacology, Journal Year: 2019, Volume and Issue: 10

Published: March 29, 2019

Allergic rhinitis is a chronic upper respiratory disease estimated to affect between 10-40% of the worldwide population. The mechanisms underlying allergic are highly complex and involve multiple immune cells, mediators, cytokines. As such, development single drug treat inflammation and/or symptoms confounded by complexity pathophysiology. Complete avoidance allergens that trigger AR not possible without cure, available therapeutic options typically focused on achieving symptomatic relief. Topical therapies offer many advantages over oral therapies, such as delivering greater concentrations drugs receptor sites at source reduced risk systemic side effects. This review describes pathophysiology identifies mechanism(s) action topical treatments including antihistamines, steroids, anticholinergics, decongestants chromones in relation Following literature discussion future strategies for treatment provided.

Language: Английский

Citations

82
Quercetin improves the imbalance of Th1/Th2 cells and Treg/Th17 cells to attenuate allergic rhinitis DOI Creative Commons
Ke Xia, Ziqi Chen, Xiaoqiang Wang

et al.

Autoimmunity, Journal Year: 2023, Volume and Issue: 56(1)

Published: March 20, 2023

Allergic rhinitis (AR) is a common inflammation that affects many people globally. Quercetin has anti-allergic biological activity in AR. Here, we aimed to explore the effects of quercetin on type 1 helper T (Th1)/Th2 and regulatory cells (Treg)/Th17 balance. We established an ovalbumin (OVA)-induced mouse model orally administered 20, 35, 50 mg/kg/day quercetin. The nasal symptoms mice were observed. immunoglobulin levels, Treg/Th17-related factors, pro-inflammatory factors examined by ELISA. differentiated visualized using diff-quick staining assay. histopathology was evaluated H&E, periodic acid Schiff (PAS), Giemsa results showed attenuated OVA-induced rubbing sneezing. reduced IgE, IgG1, histamine, increased IgG2 serum. number goblet tissues elevated OVA Moreover, Treg cell percentage, levels IL-17, TGF-β, IL-6, TNF-α, decreased Th17 IL-10 FOXP3 while abrogated their induced OVA. Additionally, inactivated NF-κB pathway. Taken together, AR balancing Th1/Th2, Treg/Th17 ratios, inactivating suggested may use for treatment.

Language: Английский

Citations

34
Bergapten ameliorates combined allergic rhinitis and asthma syndrome after PM2.5 exposure by balancing Treg/Th17 expression and suppressing STAT3 and MAPK activation in a mouse model DOI Creative Commons
Yuna Jiang, Thi Van Nguyen, Juan Jin

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 164, P. 114959 - 114959

Published: May 31, 2023

Combined allergic rhinitis and asthma syndrome (CARAS) causes chronic respiratory inflammation in individuals. Long-term exposure to particulate matter 2.5 (PM2.5; particles µm or less diameter) can aggravate damage. Bergapten (5-methoxysporalen) is a furocoumarin mostly found bergamot essential oil has significant antioxidant, anticancer, anti-inflammatory activity. This study created model which CARAS was exacerbated by PM2.5 exposure, BALB/c mice explored the potential of bergapten as therapeutic agent. The medication increased ovalbumin (OVA)-specific immunoglobulin (Ig) G2a level serum decreased OVA-specific IgE IgG1 expression. Clinical nasal symptoms diminished significantly, with weakened inflammatory reaction both mucosa lungs. Furthermore, controlled T helper (Th)1 Th2 ratio increasing cytokines associated Th1-like interleukin (IL)-12 interferon gamma decreasing IL-4, IL-5, IL-13. Factors closely related balance between regulatory cells Th17 (such IL-10, IL-17, Forkhead box protein P3, retinoic-related orphan receptor gamma) were also regulated. Notably, pro-inflammatory IL-6, IL-1β, tumor necrosis factor-alpha reduced bergapten, suppressed activation signal transducer activator transcription 3 signaling pathway mitogen-activated kinase pathway. Therefore, might have agent for CARAS.

Language: Английский

Citations

24
Probiotic Lactobacillus plantarum GUANKE effectively alleviates allergic rhinitis symptoms by modulating functions of various cytokines and chemokines DOI Creative Commons
Haijun Han, Guoliang Chen, Bin Zhang

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 10

Published: Jan. 15, 2024

Background Currently, the prevalence of allergic rhinitis (AR) remains high and there is a great need to develop better safer ways alleviate AR symptoms. The Lactobacillus plantarum GUANKE probiotic was reported as an immunomodulator through maintaining Th1/Th2 balance. This study aimed determine efficacy in subjects. Methods Adults aged from 18 60 years old previously suffered were recruited received probiotics treatment for 4 weeks. questionnaires Total nasal symptom scores (TNSS), total non-nasal score (TNNSS), control assessment test (RCAT) used assess effectiveness before after treatment. serum allergen-specific IgE cytokines also determined at baseline weeks administration. Results results showed that TNSS TNNSS significantly reduced RCAT increased compared baseline. sub-symptom rhinorrhea, itching, sneezing, tearing each questionnaire significant changes, level markedly decreased. We further measured inflammatory-related proteins found 20 (6 upregulated 14 downregulated) changed baseline, including IL-4, IL-7, IL-20, IL-33, CXCL1, CXCL5, CXCL6, CXCL11, CCL4, CCL23, TGF-alpha, LAP-TGF-beta-1, MMP-1, MMP-10, AXIN1, NT-3, OSM, SCF, CD6, NRTN. Enrichment analysis these altered mainly enriched cytokine chemokine-related signaling pathways. Conclusion Taken together, this demonstrated can serve effective immunobiotic AR, which realized balance by modulating functions various chemokines.

Language: Английский

Citations

8
JAK/STAT inhibitors and other small molecule cytokine antagonists for the treatment of allergic disease DOI
Michael Howell,

Carolyn Fitzsimons,

Paul A. Smith

et al.

Annals of Allergy Asthma & Immunology, Journal Year: 2018, Volume and Issue: 120(4), P. 367 - 375

Published: Feb. 14, 2018

Language: Английский

Citations

67
Next-Generation of Allergen-Specific Immunotherapies: Molecular Approaches DOI
Mirela Curin, Musa Khaitov, А. В. Караулов

et al.

Current Allergy and Asthma Reports, Journal Year: 2018, Volume and Issue: 18(7)

Published: June 9, 2018

Language: Английский

Citations

60
Local Allergic Rhinitis DOI
Paloma Campo, María Salas, Natalia Blanca‐López

et al.

Immunology and Allergy Clinics of North America, Journal Year: 2016, Volume and Issue: 36(2), P. 321 - 332

Published: Feb. 26, 2016

Language: Английский

Citations

56
Saikosaponin A ameliorates nasal inflammation by suppressing IL-6/ROR-γt/STAT3/IL-17/NF-κB pathway in OVA-induced allergic rhinitis DOI

Chun Hua Piao,

Chang Ho Song, Eun Jung Lee

et al.

Chemico-Biological Interactions, Journal Year: 2019, Volume and Issue: 315, P. 108874 - 108874

Published: Oct. 24, 2019

Language: Английский

Citations

54