Journal of materials research/Pratt's guide to venture capital sources, Journal Year: 2024, Volume and Issue: 39(15), P. 2215 - 2227
Published: July 9, 2024
Language: Английский
Applied Sciences, Journal Year: 2024, Volume and Issue: 14(6), P. 2270 - 2270
Published: March 8, 2024
Regenerative dentistry has experienced remarkable advancement in recent years. The interdisciplinary discoveries stem cell applications and scaffold design fabrication, including novel techniques biomaterials, have demonstrated immense potential the field of tissue engineering regenerative therapy. Scaffolds play a pivotal role by facilitating regeneration restoring damaged or missing dental structures. These biocompatible biomimetic structures serve as temporary framework for cells to adhere, proliferate, differentiate into functional tissues. This review provides concise overview evolution strategies dentistry, along with analysis (Bard v2.0 based on Gemini neural network architecture) most commonly employed materials used fabrication during last 10 Additionally, it delves bioprinting, colonization procedures, outlines prospects regenerating whole tooth future. Moreover, discusses optimal conditions maximizing mesenchymal utilization optimizing personalization through precise 3D bioprinting. highlights advancements development, particularly advent bioprinting technologies, is comprehensive literature search influential publications this field.
Language: Английский
Citations
14
Cells, Journal Year: 2025, Volume and Issue: 14(6), P. 422 - 422
Published: March 12, 2025
With increasing life expectancy and an aging population, the demand for dental treatments that preserve natural teeth has grown significantly. Among these treatments, endodontic therapies pulpitis apical periodontitis play a vital role, not only in keeping occlusal function, but also preventing exacerbation of systemic diseases. Both are primarily caused by infections oral pathobiont within root canal, leading to inflammation destruction pulp, periodontal tissue, bone. Standard canal therapy aims remove infection source facilitate tissue healing through body’s regenerative capacity. However, challenges remain, including limited tooth functionality after complete pulp removal insufficient recovery large bone defect periodontitis. To address limitations, have emerged as promising alternatives. Pulp regeneration seeks restore while repair regenerate defects affected tissue.
Language: Английский
Citations
1
Cells, Journal Year: 2024, Volume and Issue: 13(12), P. 1065 - 1065
Published: June 19, 2024
Bone tissue injuries within oral and dental contexts often present considerable challenges because traditional treatments may not be able to fully restore lost or damaged bone tissue. Novel approaches involving stem cells targeted 3D scaffolds have been investigated in the search for workable solutions. The use of cell-assisted regeneration is a crucial component engineering techniques designed overcome drawbacks grafts. This study provides detailed review scaffold applications with dentistry. focuses on while covering broad range studies explaining dentistry through presentation conducted this field. role different regenerative medicine covered great detail reviewed literature. These addressed wide subjects, including effects platelet concentrates during surgery specific combinations, such as human pulp animal model regeneration, promote models. Noting developments, research works consider methods improve vascularization explore 3D-printed scaffolds, secretome applications, mesenchymal cells, biomaterials regeneration. thorough assessment outlines possible developments these cycles insights suggestions additional study. Furthermore, alternative creative regenerating include biophysical stimuli, mechanical stimulation, magnetic field therapy, laser nutritional supplements diet, gene biomimetic materials. innovative offer promising avenues future development
Language: Английский
Citations
6
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: March 26, 2024
Abstract This study evaluates the effects of a green tea (Camellia sinensis) and hyaluronic acid gel on fibroblast activity alveolar bone repair following third molar extractions. By examining gene expression related to cell survival, proliferation, angiogenesis, bridges in vitro findings with clinical outcomes split-mouth randomized trial. Human fibroblasts were exposed treatment gel, analysing through RT-qPCR. Twenty participants undergoing bilateral extractions received test one side placebo other. Assessments included patient-reported outcomes, professional evaluations, radiographic analyses at multiple postoperative intervals. The significantly enhanced AKT, CDKs, VEGF expressions, indicating positive effect angiogenesis proliferation. Clinically, it resulted reduced exudate, swelling, secondary interventions, radiographs showing improved density after 90 days. improves soft tissue healing post-extraction, offering promising adjunctive therapy for enhancing recovery. represents novel adjuvant option facilitating extractions, highlighting its potential utility dental practice.
Language: Английский
Citations
4
The Journal of the American Dental Association, Journal Year: 2025, Volume and Issue: 156(1), P. 1 - 2
Published: Jan. 1, 2025
Language: Английский
Citations
0
Dentistry, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 13, 2025
Traumatic dental injuries (TDIs) represent a significant global healthcare challenge, affecting different age groups and socioeconomic strata. This comprehensive chapter presents contemporary advances in diagnosing, managing, preventing TDIs, integrating evidence-based approaches with emerging technologies biological interventions. The text systematically addresses the multifaceted nature of trauma, from immediate emergency response to long-term rehabilitation, while considering broader implications for systems society. Recent developments diagnostic technologies, including artificial intelligence-assisted imaging advanced assessment tools, have transformed initial evaluation trauma. explores innovative treatment modalities, encompassing regenerative endodontics, stem cell applications, computer-guided interventions alongside traditional approaches. Particular emphasis is placed on digital workflows, teledentistry minimally invasive techniques that revolutionized trauma management. critically examines impact TDI, direct indirect costs, quality life considerations, resource allocation. Special attention given age-specific management protocols, medically compromised patients, legal-ethical considerations. concludes an analysis future directions traumatology, providing framework continued advancement.
Language: Английский
Citations
0
Biomolecules, Journal Year: 2025, Volume and Issue: 15(4), P. 546 - 546
Published: April 8, 2025
Advanced bioengineering, popularly known as regenerative dentistry, has emerged and is steadily developing with the aim of replacement lost or injured tissues in mouth using stem cells other biomaterials. Conventional therapies for reparative instance fillings crowns, mainly entail replenishment affected without much concern given to regeneration tissues. However, these methods do not enable natural function aesthetics teeth be maintained long term. There are several strategies that offer potential address limitations extent biologically restoring their components, like pulp, dentin, bone, periodontal Hence, cells, especially dental tissue derived such pulp ligament apical papilla quite promising this regard. These have potentiality generating precise cell lineages thus vital healing renewal. Further, hydrogels, growth factors, synthetic scaffolds help supporting growth, proliferation, differentiation into functional This review aims at describing process cell-based repair biomaterials regeneration, also looks practice prospects analysing case reports clinical investigations demonstrate efficacy technique. Nonetheless, tremendous dentistry a reality currently challenged by biological technical constraints, scarcity sources, inadequate vascularization, integration materials used procedure. As we move forward, subsequent developments technology, biomaterial optimization, individualized treatment methods, which might become increasingly integrated practices globally. there regulatory, ethical economic issues may pose hurdle further advancement discipline.
Language: Английский
Citations
0
IGI Global eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 123 - 154
Published: March 28, 2025
This chapter gives an overview of the emerging field regenerative dentistry with emphasis on use biological approaches to enhance repair, regeneration, and replacement injured tissues in oral cavity. The is divided into three key areas: medical applications stem cells, tissue engineering, growth factors. deals stem-cell-based regeneration dental pulp, periodontal tissue, issues related cell therapy such as ethics, regulation, technique. Furthermore, it addresses design manufacturing natural, synthetic, blended scaffolds specifically for dentistry, biocompatibility scaffolds, ability degrade a controlled manner match healing rates. also briefly summarizes factors bone well post-surgical wound after surgeries, importance appropriate delivery systems.
Language: Английский
Citations
0
International Journal of Community Medicine and Public Health, Journal Year: 2025, Volume and Issue: 12(5), P. 2374 - 2382
Published: April 30, 2025
Periodontal treatment has evolved significantly due to technological advancements and novel methodologies. Between 2020 2024, integrating digital technologies, therapeutic innovations, advanced modalities transformed clinical practice, improving patient outcomes. This review examines recent developments in periodontal care, focusing on methodologies such as laser therapy, guided tissue regeneration (GTR), imaging. Key technologies analyzed include antimicrobial photodynamic therapy (aPDT), cone-beam computed tomography (CBCT), computer-aided design/manufacturing (CAD/CAM), 3D bioprinting. The integration of these enhanced the diagnostic, therapeutic, prognostic capabilities practitioners. Additionally, biomaterials engineering have shown promise regenerative supporting natural healing minimizing invasive surgical interventions. Modern improved efficacy care. highlights evolution techniques, assessing their benefits limitations contemporary practice.
Language: Английский
Citations
0
Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(3), P. 80 - 80
Published: Feb. 24, 2025
Polymer-based scaffolds have emerged as transformative materials in regenerative dentistry, enabling the restoration and replacement of dental tissues through tissue engineering approaches. These scaffolds, derived from natural synthetic polymers, mimic extracellular matrix to promote cellular attachment, proliferation, differentiation. Natural polymers such collagen, chitosan, alginate offer biocompatibility bioactivity, while alternatives like polylactic acid (PLA) polycaprolactone (PCL) provide tunable mechanical properties degradation rates. Recent advancements highlight integration bioactive molecules nanotechnology enhance potential these materials. Furthermore, developing hybrid combining addresses strength challenges, paving way for patient-specific treatments. Innovations 3D bioprinting stimuli-responsive biomaterials are expected refine scaffold design further, improving therapeutic precision clinical outcomes. This review underscores critical role polymer-based advancing focusing on their applications, advantages, limitations.
Language: Английский
Citations
0