A structure-functionality insight into the bioactivity of microbial polysaccharides toward biomedical applications: A review

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 335, P. 122078 - 122078

Published: March 21, 2024

Language: Английский

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Antioxidant and anti-aging activities of Longan crude and purified polysaccharide (LP-A) in nematode Caenorhabditis elegans

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 267, P. 131634 - 131634

Published: April 16, 2024

Language: Английский

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Bacillus coagulans (Weizmannia coagulans) XY2 attenuates Cu-induced oxidative stress via DAF-16/FoxO and SKN-1/Nrf2 pathways and gut microbiota regulation

Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 457, P. 131741 - 131741

Published: June 1, 2023

Language: Английский

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Anti-aging activities of Rehmannia glutinosa Libosch. crude polysaccharide in Caenorhabditis elegans based on gut microbiota and metabonomic analysis

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 253, P. 127647 - 127647

Published: Oct. 24, 2023

Language: Английский

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Protective effect of carbon dots as antioxidants on intestinal inflammation by regulating oxidative stress and gut microbiota in nematodes and mouse models

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 131, P. 111871 - 111871

Published: March 16, 2024

Language: Английский

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Lentinan-loaded GelMA hydrogel accelerates diabetic wound healing through enhanced angiogenesis and immune microenvironment modulation

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 264, P. 130716 - 130716

Published: March 7, 2024

Language: Английский

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Weizmannia coagulans BC99 Attenuates Oxidative Stress Induced by Acute Alcoholic Liver Injury via Nrf2/SKN-1 Pathway and Liver Metabolism Regulation

Antioxidants, Journal Year: 2025, Volume and Issue: 14(1), P. 117 - 117

Published: Jan. 20, 2025

Acute alcoholic liver injury (AALI) remains a significant global health concern, primarily driven by oxidative stress. This study investigated the protective mechanisms of Weizmannia coagulans BC99 against alcohol-induced stress using dual model in rats and Caenorhabditis elegans. In rats, excessive alcohol was predominantly metabolized via CYP2E1 pathway, leading to severe However, intervention with suppressed expression enhanced antioxidant enzyme activities through Nrf2/SKN-1 thereby alleviating Additionally, treatment elevated glutamate aspartate levels while reducing glycerate glucose, which collectively increased glutathione mitigated triggered glucose metabolism disorders. C. elegans, reduced ROS upregulating Nrf2/skn-1, daf-16, their downstream genes, consequently biotoxicity associated damage. The effects were markedly diminished skn-1 mutant (GR2245) daf-16 (CF1038), further confirming pivotal roles SKN-1 DAF-16 pathways BC99-mediated protection. Taken together, these findings reveal that mitigates activating pathway regulating metabolites eliminate excess ROS, providing theoretical basis for application probiotics preventing acute injury.

Language: Английский

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Mulberry leaves attenuate D-galactose-induced aging in vivo and in vitro

Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 311, P. 116286 - 116286

Published: March 23, 2023

Language: Английский

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Lactiplantibacillus plantarum A72, a Strain with Antioxidant Properties, Obtained through ARTP Mutagenesis, Affects Caenorhabditis elegans Anti-Aging

Foods, Journal Year: 2024, Volume and Issue: 13(6), P. 924 - 924

Published: March 19, 2024

This research endeavored to elucidate the antioxidant attributes of lactic acid bacteria, specifically their impact on anti-aging and lifespan augmentation in Caenorhabditis elegans. The study focused Lactiplantibacillus plantarum A72, identified through ARTP mutagenesis for its potent properties. In vitro analysis affirmed free radical neutralizing capacity. C. elegans, strain not only extended by 25.13% amplified motility 2.52-fold, but also maintained reproductive capabilities. Remarkably, Lpb. A72 diminished reactive oxygen species (ROS) malondialdehyde (MDA) levels elegans 34.86% 69.52%, respectively, while concurrently enhancing enzyme activities. bolstered survival rates 46.33% 57.78% under high temperature H2O2 conditions, respectively. Transcriptomic scrutiny revealed that could retard aging extend upregulating sod-5 hsp-16.1 genes downregulating fat-6 lips-17 genes. These findings propose as a potential bacteria.

Language: Английский

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GABA attenuates neurotoxicity of zinc oxide nanoparticles due to oxidative stress via DAF-16/FoxO and SKN-1/Nrf2 pathways

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 934, P. 173214 - 173214

Published: May 14, 2024

Language: Английский

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