Analytical Chemistry,
Journal Year:
2024,
Volume and Issue:
96(37), P. 14826 - 14834
Published: Sept. 4, 2024
Bacteria
can
cause
infectious
diseases
even
at
ultralow
concentrations
(<1
CFU/mL).
It
is
important
to
rapidly
identify
bacterial
contamination
concentrations.
Herein,
FITC-labeled
gelatinase-sensitive
nanoparticles
(GNPs@FITCs)
and
NFM@GNP@FITCs
are
designed
fabricated
as
concentration
bacteria
detection
platforms
based
on
an
enzymatic
cascade
reaction-amplifying
strategy.
Bacterial
secretions
could
trigger
the
dissociation
of
GNPs@FITCs
release
FITC,
with
gelatinase
used
model
secretion.
The
detectable
signal
be
amplified
effectively
by
gelatinase-triggered
reaction.
was
evaluated
change
in
fluorescence
density.
results
showed
that
for
identifying
qualitatively,
when
lower
than
1
CFU/mL.
Moreover,
method
has
better
timeliness
convenience,
compared
national
standards.
As
solid
films,
have
long-term
storage
stability
GNPs@FITCs.
potential
applications
GNPs@FITC
were
proved
detecting
pathogenic
food.
All
great
screening
qualitatively.
Advanced Healthcare Materials,
Journal Year:
2023,
Volume and Issue:
12(30)
Published: July 22, 2023
The
healing
of
biofilm-infected
diabetic
wounds
characterized
by
a
deteriorative
tissue
microenvironment
represents
substantial
clinical
challenge.
Current
treatments
remain
unsatisfactory
due
to
the
limited
antibiofilm
efficacy
caused
weak
and
biofilm
permeability
drugs
risk
reinfection
during
process.
To
address
these
issues,
an
integrated
therapeutic
preventive
nanozyme-based
microneedle
(denoted
as
Fe2
C/GOx@MNs)
is
engineered.
dissolvable
tips
with
enough
mechanical
strength
can
deliver
rapidly
release
C
nanoparticles
(NPs)/glucose
oxidase
(GOx)
in
active
regions,
enhancing
NPs/GOx,
ultimately
achieving
highly
efficient
elimination.
Meanwhile,
chitosan
backing
layer
not
only
act
excellent
physical
barrier
between
wound
bed
external
environment,
but
also
prevent
bacterial
reinvasion
its
superior
antibacterial
property.
Significantly,
elimination
prevention
abilities
C/GOx@MNs
on
are
proved
methicillin-resistant
Staphylococcus
aureus-biofilm-infected
mouse
model
full-thickness
wound.
Together,
results
demonstrate
promising
application
healing.
Polymers,
Journal Year:
2023,
Volume and Issue:
15(21), P. 4327 - 4327
Published: Nov. 5, 2023
In
recent
years,
there
has
been
a
growing
interest
in
the
use
of
gelatin
nanoparticles
(GNPs)
for
treatment
infectious
diseases.
The
inherent
properties
these
make
them
attractive
options
drug
delivery.
Their
biocompatibility
ensures
that
they
can
interact
with
biological
systems
without
causing
adverse
reactions,
while
their
biodegradability
break
down
harmlessly
body
once
function
is
performed.
Furthermore,
capacity
controlled
release
therapeutic
agents
be
delivered
over
sustained
period,
thereby
enhancing
efficacy.
This
review
examines
current
landscape
GNP-based
delivery,
specific
focus
on
its
potential
applications
and
challenges
context
Key
include
controlling
rates,
ensuring
nanoparticle
stability
under
physiological
conditions,
scaling
up
production
maintaining
quality,
mitigating
immunogenic
optimizing
loading
efficiency,
tracking
biodistribution
clearance
GNPs
body.
Despite
hurdles,
hold
promising
realm
disease
treatment.
Ongoing
research
innovation
are
essential
to
overcome
obstacles
completely
harness
clinical
applications.
Biomaterials Science,
Journal Year:
2023,
Volume and Issue:
11(13), P. 4430 - 4451
Published: Jan. 1, 2023
Wound
management
is
a
serious
concern
worldwide,
inflicting
huge
social
and
economic
burden
on
patients
healthcare
systems,
research
into
efficient
wound-management
measures
crucial.
Journal of Drug Delivery Science and Technology,
Journal Year:
2024,
Volume and Issue:
93, P. 105409 - 105409
Published: Jan. 29, 2024
Despite
aiming
to
improve
the
healing
process,
wound
dressings
that
have
been
developed
thus
far
still
present
high
production
costs,
uncontrolled
drug
delivery,
and
are
unable
fully
re-establish
all
features
of
native
skin.
In
this
field,
development
light-responsive
has
emerging
due
possibility
controlling
delivery
therapeutic
agents
both
in
time
space.
Moreover,
strategy
also
explored
guide
materials'
polymerization/crosslinking,
as
well
mediate
approaches
based
on
photothermal
or
photodynamic
effects.
Among
different
approaches,
utilization
near-infrared
(NIR)
light
holds
a
translational
potential
minimal
interactions
with
biological
components
higher
penetration
capacity
human
tissues.
way,
biomaterials
responsive
NIR
produced
active
dressings.
Therefore,
review
aims
provide
an
overview
advantages
particular,
its
thermal,
photodynamic,
photobiomodulation,
imaging
potential.
Furthermore,
antibacterial,
drug-release,
cellular
responses
can
be
obtained
application
NIR-responsive
described
focusing
impact
process.
Materials Today Bio,
Journal Year:
2023,
Volume and Issue:
19, P. 100579 - 100579
Published: Feb. 11, 2023
Tissue
injury
is
a
common
clinical
problem,
which
may
cause
great
burden
on
patients'
life.
It
important
to
develop
functional
scaffolds
promote
tissue
repair
and
regeneration.
Due
their
unique
composition
structure,
microneedles
have
attracted
extensive
attention
in
various
tissues
regeneration,
including
skin
wound,
corneal
injury,
myocardial
infarction,
endometrial
spinal
cord
et
al.
Microneedles
with
micro-needle
structure
can
effectively
penetrate
the
barriers
of
necrotic
or
biofilm,
therefore
improving
bioavailability
drugs.
The
use
deliver
bioactive
molecules,
mesenchymal
stem
cells,
growth
factors
Biomaterials Science,
Journal Year:
2023,
Volume and Issue:
12(3), P. 530 - 563
Published: Nov. 7, 2023
Wearable
devices
have
become
prevalent
in
biomedical
studies
due
to
their
convenient
portability
and
potential
utility
biomarker
monitoring
for
healthcare.
Accessing
interstitial
fluid
(ISF)
across
the
skin
barrier,
microneedle
(MN)
is
a
promising
minimally
invasive
wearable
technology
transdermal
sensing
drug
delivery.
MN
has
overcome
limitations
of
conventional
administration,
making
it
another
prospective
mode
delivery
after
oral
injectable.
Subsequently,
combining
with
multiple
approaches
led
its
extensive
application
detect
biomarkers
ISF.
In
this
context,
employing
platforms
control
schemes
merge
diagnostic
therapeutic
capabilities
into
theranostic
systems
will
facilitate
on-demand
therapy
point-of-care
diagnostics,
paving
way
future
technologies.
A
comprehensive
analysis
growing
advances
microneedles
presented
review
summarize
latest
academics
field
offer
reference
issues
that
need
be
addressed
Covering
an
array
novel
studies,
we
discuss
following
main
topics:
classification
field,
considerations
design,
current
applications
diagnosis
therapy,
regulatory
landscape
prospects
applications.
This
sheds
light
on
significance
microneedle-based
innovations,
presenting
implications
contributions
community
healthcare
The
provides
understanding
field's
state
potential,
valuable
resource
clinicians
seeking
harness
full
