Factors affecting the penetration in microneedles and PLGA nanoparticle-assisted drug delivery: Importance of preparation and formulation DOI Creative Commons
Lu Geng, Baohua Li,

Qiyi Deng

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: May 24, 2023

Abstract Purpose Oral administration of the first-line antidepressant paroxetine (PAX) has certain limitations, including difficulty in reaching brain due to oral absorption. Although there are many invasive and non-invasive strategies available cross blood–brain barrier (BBB), they run counter long-term convenience for patients. Methods We herein designed a simple PAX-loaded nanoparticle-integrated dissolving microneedles system (PAX-NP-DMNs), aiming improve bioavailability PAX through synergistic permeation-enhancing effect (MNs) nanoparticles (NPs). Results assessed NPs characteristics before after MNs preparation confirmed successful construction PAX-NP-DMNs based on differential scanning calorimetry, X-ray diffraction, Fourier transform infrared spectroscopy. In mechanical strength test, addition increased by 0.43 times prolonged release from 1 h 48 h; over 40 than solution isolated skin penetration permeability experiments. Moreover, good biocompatibility does not cause adverse reactions. Conclusion Loading into polylactic glycolic copolymer adding them can effectively problem MNs. easily penetrate provide rapid painless delivery without causing effects, thus offering more convenient effective method treatment central nervous diseases.

Language: Английский

Microneedles Based on a Biodegradable Polymer—Hyaluronic Acid DOI Open Access
Jagoda Chudzińska, Agata Wawrzyńczak, Agnieszka Feliczak‐Guzik

et al.

Polymers, Journal Year: 2024, Volume and Issue: 16(10), P. 1396 - 1396

Published: May 14, 2024

Transdermal transport can be challenging due to the difficulty in diffusing active substances through outermost layer of epidermis, as primary function skin is protect against entry exogenous compounds into body. In addition, penetration epidermis for hydrophilic nature and particles larger than 500 Da highly limited physiological properties non-polar its layer, namely stratum corneum. A solution this problem use microneedles, which “bypass” problematic epidermal by dispensing substance directly deeper layers skin. Microneedles obtained with various materials come different types. Of special interest are carriers based on biodegradable biocompatible polymers, such polysaccharides. Therefore, paper reviews latest literature methods obtain hyaluronic acid-based microneedles. It focuses current advancements field consequently provides an opportunity guide future research area.

Language: Английский

Citations

9
Advances in biomedical systems based on microneedles: design, fabrication, and application DOI
Xinghao Wang, Zifeng Wang, Min Xiao

et al.

Biomaterials Science, Journal Year: 2023, Volume and Issue: 12(3), P. 530 - 563

Published: Nov. 7, 2023

Wearable devices have become prevalent in biomedical studies due to their convenient portability and potential utility biomarker monitoring for healthcare. Accessing interstitial fluid (ISF) across the skin barrier, microneedle (MN) is a promising minimally invasive wearable technology transdermal sensing drug delivery. MN has overcome limitations of conventional administration, making it another prospective mode delivery after oral injectable. Subsequently, combining with multiple approaches led its extensive application detect biomarkers ISF. In this context, employing platforms control schemes merge diagnostic therapeutic capabilities into theranostic systems will facilitate on-demand therapy point-of-care diagnostics, paving way future technologies. A comprehensive analysis growing advances microneedles presented review summarize latest academics field offer reference issues that need be addressed Covering an array novel studies, we discuss following main topics: classification field, considerations design, current applications diagnosis therapy, regulatory landscape prospects applications. This sheds light on significance microneedle-based innovations, presenting implications contributions community healthcare The provides understanding field's state potential, valuable resource clinicians seeking harness full

Language: Английский

Citations

20
The promising application of hydrogel microneedles in medical application DOI

Yanping Wu,

Ziyan Tang,

Shan Ma

et al.

Journal of Pharmacy and Pharmacology, Journal Year: 2023, Volume and Issue: 75(8), P. 1011 - 1020

Published: June 18, 2023

Abstract Objectives Hydrogel microneedles are emerging, and promising mainly composed of swelling polymers. This review is intended to summarize the preparation materials, formation mechanisms, applications existing problems hydrogel microneedles. Methods We collected literature on application in recent years, summarized their mechanism drugs delivery. Key findings have higher safety capabilities controlled drug release, been used tumour diabetes treatment, as well clinical monitoring. In shown great potential delivery, played role whitening, anti-inflammatory promoting healing. Conclusions As an emerging delivery idea, for has gradually become a research hotspot. will provide systematic vision favourable development medicine, especially

Language: Английский

Citations

17
Betamethasone-loaded dissolvable microneedle patch for oral ulcer treatment DOI
Xiaoli Guo,

Tingting Zhu,

Xixi Yu

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2022, Volume and Issue: 222, P. 113100 - 113100

Published: Dec. 16, 2022

Language: Английский

Citations

27
Dissolvable hybrid microneedle patch for efficient delivery of curcumin to reduce intraocular inflammation DOI
Hui Shi,

Shuo Huai,

Hui-Ling Wei

et al.

International Journal of Pharmaceutics, Journal Year: 2023, Volume and Issue: 643, P. 123205 - 123205

Published: July 6, 2023

Language: Английский

Citations

16
Hyaluronic acid dissolving microneedle patch loaded with tranexamic acid for melasma treatment DOI
Cai Zhang, Xuejiao Song, Chuan Ma

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 270, P. 132255 - 132255

Published: May 8, 2024

Language: Английский

Citations

6
In vivo skin optical clearing for improving imaging and light-induced therapy: a review DOI Creative Commons

Qing Xia,

Dongyu Li, Tingting Yu

et al.

Journal of Biomedical Optics, Journal Year: 2023, Volume and Issue: 28(06)

Published: June 6, 2023

Skin is the largest organ and also first barrier of body. diseases are common, cutaneous microcirculation relative to various diseases. Researchers attempt develop novel imaging techniques obtain complex structure, components, functions skin. Modern optical provide a powerful tool with non-invasiveness, but performance suffers from turbid character

Language: Английский

Citations

11
Mechanical strength affecting the penetration in microneedles and PLGA nanoparticle-assisted drug delivery: Importance of preparation and formulation DOI Open Access
Lu Geng, B Li,

Luping Lin

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 173, P. 116339 - 116339

Published: Feb. 29, 2024

Microneedles (MNs) prepared from polymeric materials are painless and minimally invasive, safe efficient, but they hindered by low mechanical strength single diverse drug release pattern. Due to the distinctive dimensions of poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs), integration nano-technology with microneedles can effectively improve penetration delivery efficiency through stratum corneum. We herein designed a simple paroxetine (PAX)-loaded PLGA nanoparticles-integrated dissolving system (PAX-NPs-DMNs), aiming bioavailability PAX synergistic permeation-enhancing effect (DMNs) NPs. PAX-NPs-DMNs had complete tips molding rate (Neff) (94.06 ± 2.16) %, 15×15 quadrangular-conical microneedle array an overall fracture force 301.10 N, which were improved nearly 0.50 times compared blank (HA-DMNs) (PAX-DMNs). could extend duration 1 h 24 cumulative permeability per unit area (Qn) was 47.66 7.37 higher than PAX-DMNs groups. be rapidly dissolved within 10 min without hindering skin healing or causing adverse reactions. This study confirmed that DMNs, easily penetrate provide sustained effects, thus offering more convenient effective method for central nervous diseases.

Language: Английский

Citations

4
Cryo-microneedle enabled transdermal delivery of two-dimensional Cu(Ⅱ)-TCPP nanomaterials for synergistic photodynamic-chemodynamic anti-tumor therapy DOI

Yanru An,

Yuanyuan Huo,

Zixu Wang

et al.

European Polymer Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113888 - 113888

Published: March 1, 2025

Language: Английский

Citations

0
Hyaluronic Acid Microneedles Loaded with Chinese Herbal Extracts as an Intradermal Delivery System for Hair Regeneration DOI
Jongki Hong, Bocheng Xu, Xiaole Hu

et al.

Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown

Published: April 12, 2025

Androgenic alopecia is one of the most common chronic problems for dermatologists worldwide. Some Chinese herbal extracts have been shown to promote hair growth, but active ingredients are difficult enter dermis. Therefore, delivering into dermis becomes a key factor. Herein, Platycladus orientalis leaf extract (PO-ex) was obtained using ethanol as solvent, and then hyaluronic acid methacrylate/hyaluronic (HAMA/HA) hydrogel loaded with PO-ex prepare microneedles (PO-ex MN). The double cross-linked HAMA/HA provides sufficient mechanical strength pierce stratum corneum deliver dermis; can effectively improve environment follicle cell proliferation by removing reactive oxygen free radicals; in addition, self-repair reaction caused microneedle stimulation activates Wnt/β-catenin pathway associated trauma repair promotes growth. MN potential therapeutic strategy treatment androgenic alopecia.

Language: Английский

Citations

0