Advances in microneedles for delivery of active ingredients of natural herbals DOI
Lin Fan, Jiang Sun, Dawei He

et al.

Biointerphases, Journal Year: 2022, Volume and Issue: 19(6)

Published: Nov. 1, 2022

The active ingredients of natural herbs have been extracted to act on different targets in the body exert multiple effects. However, traditional oral administration and intravenous injection herbal medicines are also susceptible many side Transdermal drug delivery by microneedles can overcome shortcomings these systems. be delivered dermis or connective tissue layer five types microneedles: solid, hollow, coated, dissolving, hydrogel. Subsequently, target points through circulation their In this study, we classified that deliver summarized advantages disadvantages as well preparation methods applications, guide development clinical applications other transdermal microneedles.

Language: Английский

Recent advances in iontophoresis-assisted microneedle devices for transdermal biosensing and drug delivery DOI Creative Commons
Gaobo Wang,

Noboru MORIYAMA,

Soichiro Tottori

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101504 - 101504

Published: Jan. 19, 2025

Integrating advanced manufacturing techniques and nanotechnology with cutting-edge materials has driven significant progress in global healthcare. Microneedles, recognized for their minimally invasive approach to transdermal sensing drug delivery, achieve enhanced functionality when combined iontophoresis. Iontophoresis-assisted microneedles have emerged as an innovative solution, enabling real-time biosensing precise delivery within closed-loop systems. These integrated platforms represent a major advancement personalized medicine, allowing dynamic therapeutic adjustments based on continuous feedback. This review highlights the latest developments iontophoresis-assisted biosensing, applications. It delves into mechanisms of iontophoresis, assesses its advantages limitations, explores future directions these transformative technologies.

Language: Английский

Citations

1
Graphene-Based Polymeric Microneedles for Biomedical Applications: A Comprehensive Review DOI Creative Commons
Somayeh Moradi, Farah ’Atiqah Abdul Azam, Hossein Abdollahi

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

Transdermal drug delivery presents a promising noninvasive approach, bypassing first-pass metabolism and gastrointestinal degradation. However, the stratum corneum (SC) barrier limits absorption, necessitating development of effective systems. Microneedles, particularly polymer-based ones, offer solution by penetrating SC while avoiding critical nerves capillaries. These microneedles are biodegradable, nontoxic, easily manufacturable, making them highly attractive platform for transdermal delivery. their clinical application remains limited due to suboptimal therapeutic efficacy slow release rates. Recent advancements have introduced incorporation nanodrugs, such as nanoparticles encapsulated drugs, into enhance efficiency. Among materials explored, graphene its derivatives, including oxide (GO) reduced (rGO), garnered significant attention. Their exceptional mechanical strength, electrical conductivity, antibacterial properties not only improve performance but also rates biocompatibility. This review synthesizes current state microneedle technologies, focusing on materials, fabrication techniques, challenges. It examines potential graphene-based microneedles, comparing traditional in terms efficiency stability. The highlights key challenges, scalability, biocompatibility, complexity, suggests future research directions address these issues. quantum dots (GQDs) is identified avenue improving profiles, stability, real-time tracking diffusion. Finally, outlines emerging applications, smart systems, biosensing, monitoring, urging further exploration unlock full graphene-enhanced settings.

Language: Английский

Citations

1
Dissolving Microneedles as In Situ Chemical Reaction Chambers: from Design Strategies to Versatile Biomedical Applications DOI Open Access
Yu Tian, Lili Xia, Xinran Song

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

Abstract The skin microenvironment is a highly intricate and dynamic system, characterized by an acidic pH, diverse microbiota, various metabolites, numerous enzymes, creating both challenges opportunities for the development of innovative drug delivery systems. Dissolving Microneedles (MNs) have emerged as promising, pain‐free alternative to conventional invasive injections, offering ability deliver therapeutics through gradual degradation within skin's interstitial fluids. Building upon unique properties dissolving MNs, novel concept introduced wherein MNs serve in situ chemical reaction chambers. In this framework, can reactants or catalysts skin, enabling initiation specific reactions, such prodrug activation targeted therapy, harmful enhanced synthesis beneficial molecules. Moreover, review systematically explores potential chambers, discussing key aspects their sustained release mechanisms, design strategies, range therapeutic applications. Finally, forward‐looking perspective provided on future addressing broader clinical translation application personalized medicine.

Language: Английский

Citations

0
3D-printed microneedles for sensing applications: emerging topics and future trends DOI Creative Commons
Kelcilene B. R. Teodoro, Tamires S. Pereira, Ana Laura M.M. Alves

et al.

Advanced Sensor and Energy Materials, Journal Year: 2025, Volume and Issue: unknown, P. 100139 - 100139

Published: Feb. 1, 2025

Language: Английский

Citations

0
Combination of lipid-based nanoparticles with microneedles as a promising strategy for enhanced transdermal delivery systems: A comprehensive review DOI
Maxius Gunawan,

Angi Nadya Bestari,

Delly Ramadon

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106807 - 106807

Published: March 1, 2025

Language: Английский

Citations

0
Microneedle-Based Delivery of Metal Oxide Nanoparticles DOI
Jaison Jeevanandam, Tracy Ann Bruce‐Tagoe, Michael K. Danquah

et al.

Series in bioengineering, Journal Year: 2025, Volume and Issue: unknown, P. 299 - 315

Published: Jan. 1, 2025

Language: Английский

Citations

0
Hydrogel-Forming Microneedles in the Management of Dermal Disorders Through a Non-Invasive Process: A Review DOI Creative Commons
Popat Mohite, Abhijeet Puri, Shubham Munde

et al.

Gels, Journal Year: 2024, Volume and Issue: 10(11), P. 719 - 719

Published: Nov. 7, 2024

Microneedle (MN) technology has emerged as a promising approach for delivering therapeutic agents to the skin, offering significant potential in treating various dermal conditions. Among these technologies, hydrogel-forming microneedles (HFMNs) represent transformative advancement management of diseases through non-invasive drug delivery. These innovative devices consist micrometer-sized needles made native or crosslinked hydrophilic polymers, capable penetrating stratum corneum without damaging underlying tissues. Upon insertion, HFMNs rapidly absorb interstitial fluid, swelling form hydrogel conduit that enables efficient transport directly into microcirculation. The nature enhances patient compliance by eliminating pain and discomfort associated with traditional hypodermic needles. This allows delivery wide range drugs, including macromolecules biomacromolecules, which are often difficult administer dermally due their size polarity. Moreover, provide controlled regulated release profiles, enabling sustained effects while minimizing systemic side effects. Additionally, can be used both real-time fluid monitoring, valuable insights disease states treatment responses. dual functionality positions versatile dermatology tool effectively addressing complications. review explores use polymeric biomaterials HFMN fabrication application major disorders, such acne, psoriasis, other skin Furthermore, highlights MN-based treatments, underscoring reduce improve adherence, supported recent literature.

Language: Английский

Citations

3
Macromolecule-based stem cell and cell-free strategies for oral and maxillofacial tissue repair DOI Creative Commons
Xinying Wang, Liming He, Yiyu Zeng

et al.

Materials & Design, Journal Year: 2024, Volume and Issue: 244, P. 113203 - 113203

Published: July 29, 2024

The oral and maxillofacial regions perform mastication, swallowing, speech, expression; therefore, tissue defects can seriously affect patient physical mental health. Biomaterials be used to repair defects. However, traditional biomaterials lack biocompatibility cannot accurately match the shape of damaged tissues, leading immune rejection chronic inflammation, thereby limiting their ability. improve mesenchymal stem cell (MSC) survival by simulating extracellular matrix (ECM). MSCs have excellent self-regenerative abilities differentiate into almost all types, making them valuable for engineering. This review summarizes biomaterial-based, cell, cell-free therapies discusses properties, advantages, disadvantages, application mechanisms, with a particular focus on use in defect regeneration limitations current materials strategies. provides insights using regeneration.

Language: Английский

Citations

1
Advances in microneedles for delivery of active ingredients of natural herbals DOI
Lin Fan, Jiang Sun, Dawei He

et al.

Biointerphases, Journal Year: 2022, Volume and Issue: 19(6)

Published: Nov. 1, 2022

The active ingredients of natural herbs have been extracted to act on different targets in the body exert multiple effects. However, traditional oral administration and intravenous injection herbal medicines are also susceptible many side Transdermal drug delivery by microneedles can overcome shortcomings these systems. be delivered dermis or connective tissue layer five types microneedles: solid, hollow, coated, dissolving, hydrogel. Subsequently, target points through circulation their In this study, we classified that deliver summarized advantages disadvantages as well preparation methods applications, guide development clinical applications other transdermal microneedles.

Language: Английский

Citations

0