Nanoengineering of Phosphate/Phosphonate Drugs via Competitive Replacement with Metal‐Phenolic Networks to Overcome Breast Tumor with Lung and Bone Metastasis DOI Creative Commons

Wanrui Shi,

Dashuai Liu,

Wenjie Feng

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 12(2)

Published: Nov. 18, 2024

Abstract Phosphate and phosphonate drugs are vital in building organisms, regulating physiological processes, exhibiting diverse biological activities, including antiviral, antibacterial, antineoplastic, enzyme‐inhibitory effects. However, their therapeutic potential is limited by the lack of advanced nanoengineering technologies. Herein, a competitive coordination strategy for phosphate/phosphonate introduced. By leveraging difference capabilities between polyphenols phosphates/phosphonates with metal ions, various phosphate/phosphonate‐based nanodrugs using metal‐phenolic networks (MPNs) as templates agents constructed. The dynamic nature these bonds imparts stimuli‐responsiveness to nanodrugs, allowing targeted release therapy. As proof concept, Fe 3+ galangin used form MPN template, zoledronic acid cGAMP agents, DOX loaded drug construct DOX@Fe‐galangin@Fe‐zoledronic acid‐cGAMP nanodrugs. results demonstrate that, triggering pyroptosis activating cGAS‐STING pathway, exhibit potent cytotoxicity accurate selectivity eradicating orthotopic breast tumors, activate an antitumor immune response against lung bone metastases. Because applicable variety it holds significant enhancing clinical efficacy advancing nanodrug development complex applications.

Language: Английский

Going below and beyond the surface: Microneedle structure, materials, drugs, fabrication, and applications for wound healing and tissue regeneration DOI Creative Commons
Shang Lyu, Zhifei Dong, Xiaoxiao Xu

et al.

Bioactive Materials, Journal Year: 2023, Volume and Issue: 27, P. 303 - 326

Published: April 18, 2023

Microneedle, as a novel drug delivery system, has attracted widespread attention due to its non-invasiveness, painless and simple administration, controllable delivery, diverse cargo loading capacity. Although microneedles are initially designed penetrate stratum corneum of skin for transdermal they, recently, have been used promote wound healing regeneration tissues organs the results promising. Despite there reviews about microneedles, few them focus on tissue regeneration. Here, we review recent advances in this field. We first give an overview microneedle system terms potential cargos (e.g., small molecules, macromolecules, nucleic acids, nanoparticles, extracellular vesicle, cells), structural designs multidrug structures, adhesive structures), material selection, release mechanisms. Then briefly summarize different fabrication methods, including their advantages limitations. finally progress microneedle-assisted skin, cardiac, bone, tendon, ocular, vascular, oral, hair, spinal cord, uterine tissues). expect that our article would serve guideline readers design systems according applications, structure design, achieving better efficacy.

Language: Английский

Citations

135
Hydrogel-Forming Microneedles with Applications in Oral Diseases Management DOI Open Access
Yuqing Li,

Duohang Bi,

Zhekai Hu

et al.

Materials, Journal Year: 2023, Volume and Issue: 16(13), P. 4805 - 4805

Published: July 3, 2023

Controlled drug delivery in the oral cavity poses challenges such as bacterial contamination, saliva dilution, and inactivation by salivary enzymes upon ingestion. Microneedles offer a location-specific, minimally invasive, retentive approach. Hydrogel-forming microneedles (HFMs) have emerged for dental diagnostics therapeutics. HFMs penetrate stratum corneum, undergo swelling contact, secure attachment, enable sustained transdermal or transmucosal delivery. Commonly employed polymers polyvinyl alcohol (PVA) pyrrolidone are crosslinked with tartaric acid its derivatives while incorporating therapeutic agents. Microneedle patches provide suture-free painless to keratinized non-keratinized mucosa, facilitating site-specific treatment patient compliance. This review comprehensively discusses HFMs’ applications dentistry local anesthesia, ulcer management, periodontal treatment, etc., encompassing animal experiments, clinical trials, their fundamental impact limitations, example, restricted carrying capacity and, until now, low number of trial reports. The explores advantages future perspectives

Language: Английский

Citations

36
Magnesium metal–organic framework microneedles loaded with curcumin for accelerating oral ulcer healing DOI Creative Commons
Junhui Liu, Zhipeng Zhang,

Xiufei Lin

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Sept. 30, 2024

Language: Английский

Citations

14
Local delivery of celecoxib/indocyanine green-loaded nanomodulators for combinational photothermal/photodynamic/anti-cyclooxygenase-2 therapy of oral leukoplakia DOI

Tingting Zhu,

Zhiqin Sang,

Ye Zhou

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 159734 - 159734

Published: Jan. 1, 2025

Language: Английский

Citations

1
Reactive Oxygen Species-Responsive Gel-Based Microneedle Patches with Antimicrobial and Immunomodulating Properties for Oral Mucosa Disease Treatment DOI
Xuancheng Zhang,

Guannan Zhong,

Shiyuan Peng

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

Oral ulcer wounds are difficult to heal due bacterial infections, persistent inflammatory responses, and excessive reactive oxygen species (ROS). Therefore, the elimination of bacteria, removal ROS, reduction inflammation prerequisites for treatment mouth wounds. In this study, oligomeric proanthocyanidins (OPC) 3-(aminomethyl)phenylboronic acid-modified hyaluronic acid (HP) were used form polymer gels through dynamic covalent borate bonds. Minocycline hydrochloride (MH) was then loaded into gel, a multifunctional MH/OPC-HP microneedles (MNs) with ROS-responsive properties prepared using vacuum method. The MNs can rapidly release MH in diffusive manner sustainably OPC response ROS. gel-based extended retention oral ulcers, leading prolonged ROS scavenging effects. Cytocompatibility hemocompatibility tests showed that had good biocompatibility. Antibacterial experiments demonstrated exhibited excellent antibacterial vitro indicated could effectively clear reduce oxidative stress damage, inhibit M1-type macrophage polarization, induce M2-type polarization. Furthermore, vivo revealed pro-inflammatory cytokines, promote neovascularization, accelerate epithelial healing significantly rat model wound infection. summary, hold promise as therapeutic strategy enhancing

Language: Английский

Citations

1
Dissolving microneedles: drug delivery and disease treatment DOI

Yanling Zhuo,

F.Z. Wang, Qizhuang Lv

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: unknown, P. 114571 - 114571

Published: Feb. 1, 2025

Language: Английский

Citations

1
Microneedles for in situ tissue regeneration DOI Creative Commons
Linyu Long, Dan Ji, Cheng Hu

et al.

Materials Today Bio, Journal Year: 2023, Volume and Issue: 19, P. 100579 - 100579

Published: Feb. 11, 2023

Tissue injury is a common clinical problem, which may cause great burden on patients' life. It important to develop functional scaffolds promote tissue repair and regeneration. Due their unique composition structure, microneedles have attracted extensive attention in various tissues regeneration, including skin wound, corneal injury, myocardial infarction, endometrial spinal cord et al. Microneedles with micro-needle structure can effectively penetrate the barriers of necrotic or biofilm, therefore improving bioavailability drugs. The use deliver bioactive molecules, mesenchymal stem cells, growth factors

Language: Английский

Citations

22
Combination therapy using multifunctional dissolvable hyaluronic acid microneedles for oral ulcers DOI

Wenhui Ge,

Yijun Gao,

Liming He

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 251, P. 126333 - 126333

Published: Aug. 14, 2023

Language: Английский

Citations

18
Novel Functional Dressing Materials for Intraoral Wound Care DOI
Yutang Ding,

Zhou Zhu,

Xin Zhang

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: May 8, 2024

Intraoral wounds represent a particularly challenging category of mucosal and hard tissue injuries, characterized by the unique structures, complex environment, distinctive healing processes within oral cavity. They have common occurrence yet frequently inflict significant inconvenience pain on patients, causing serious decline in quality life. A variety novel functional dressings specifically designed for moist dynamic environment been developed realized accelerated improved wound healing. Thoroughly analyzing summarizing these materials is paramount importance enhancing understanding proficiently managing intraoral wounds. In this review, particular characteristics are firstly described. Up-to-date knowledge various forms, properties, applications existing products then intensively discussed, which categorized into animal products, plant extracts, natural polymers, synthetic products. To conclude, review presents comprehensive framework currently available dressings, with an aim to provoke inspiration future studies design more convenient versatile materials.

Language: Английский

Citations

8
Machine Learning Assists in the Design and Application of Microneedles DOI Creative Commons

Wenqing He,

Suixiu Kong,

Rumin Lin

et al.

Biomimetics, Journal Year: 2024, Volume and Issue: 9(8), P. 469 - 469

Published: Aug. 2, 2024

Microneedles (MNs), characterized by their micron-sized sharp tips, can painlessly penetrate the skin and have shown significant potential in disease treatment biosensing. With development of artificial intelligence (AI), design application MNs experienced substantial innovation aided machine learning (ML). This review begins with a brief introduction to concept ML its current stage development. Subsequently, principles fabrication methods are explored, demonstrating critical role optimizing preparation. Integration between applications therapy sensing were further discussed. Finally, we outline challenges prospects learning-assisted MN technology, aiming advance practical field smart diagnosis treatment.

Language: Английский

Citations

6