MicroRNA-122 in human cancers: from mechanistic to clinical perspectives

Cancer Cell International, Journal Year: 2023, Volume and Issue: 23(1)

Published: Feb. 20, 2023

Abstract MicroRNAs (miRNAs) are endogenous short non-coding RNAs that can regulate the expression of target genes post-transcriptionally and interact with mRNA-coding genes. MiRNAs play vital roles in many biological functions, abnormal miRNA has been linked to various illnesses, including cancer. Among miRNAs, miR-122, miR-206, miR-21, miR-210, miR-223, miR-424 have extensively studied cancers. Although research miRNAs grown considerably over last decade, much is yet be discovered, especially regarding their role cancer therapies. Several kinds dysregulation indicating miR-122 may serve as a diagnostic and/or prognostic biomarker for human Consequently, this review literature, analyzed numerous types sort out function cells enhance patient response standard therapy.

Language: Английский

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Recent insights into the roles of circular RNAs in human brain development and neurologic diseases

International Journal of Biological Macromolecules, Journal Year: 2022, Volume and Issue: 225, P. 1038 - 1048

Published: Nov. 18, 2022

Language: Английский

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MicroRNA-206 in human cancer: Mechanistic and clinical perspectives

Cellular Signalling, Journal Year: 2022, Volume and Issue: 101, P. 110525 - 110525

Published: Nov. 16, 2022

Language: Английский

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An interplay between non-coding RNAs and gut microbiota in human health

Diabetes Research and Clinical Practice, Journal Year: 2023, Volume and Issue: 201, P. 110739 - 110739

Published: June 1, 2023

Language: Английский

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The role of microRNAs in the pathophysiology of human central nervous system: A focus on neurodegenerative diseases

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 92, P. 102090 - 102090

Published: Oct. 11, 2023

Language: Английский

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The role of microRNA-185 in the pathogenesis of human diseases: A focus on cancer

Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 249, P. 154729 - 154729

Published: Aug. 16, 2023

Language: Английский

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Non-coding RNAs/DNMT3B axis in human cancers: from pathogenesis to clinical significance

Journal of Translational Medicine, Journal Year: 2023, Volume and Issue: 21(1)

Published: Sept. 13, 2023

Abstract Cancer is a complex disease with many contributing factors, and researchers have gained extensive knowledge that has helped them understand the diverse varied nature of cancer. The altered patterns DNA methylation found in numerous types cancer imply they may play part disease’s progression. human condition involves dysregulation methyltransferase 3 beta (DNMT3B) gene, prominent de novo methyltransferase, its abnormal behavior serves as an indicator for tumor prognosis staging. expression non-coding RNAs (ncRNAs), which include microRNAs (miRNA), long (lncRNAs), circular (circRNAs), critical controlling targeted gene protein translation their correlates onset tumors. NcRNAs factor influences modulation several cellular characteristics cancerous cells. These but are not limited to, drug responsiveness, angiogenesis, metastasis, apoptosis, proliferation, properties stem cell. reciprocal regulation ncRNAs DNMT3B can act synergy to influence destiny Thus, avenue advancing prevention treatment inquiry into interplay between ncRNAs. In this review, we present comprehensive overview ncRNAs/DNMT3B axis pathogenesis. This brings about valuable insights intricate mechanisms tumorigenesis provides foundation developing effective therapeutic interventions.

Language: Английский

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Non-coding RNAs: An emerging player in particulate matter 2.5-mediated toxicity

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 235, P. 123790 - 123790

Published: Feb. 22, 2023

Language: Английский

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RETRACTED: MiR-211 plays a dual role in cancer development: From tumor suppressor to tumor enhancer

Cellular Signalling, Journal Year: 2022, Volume and Issue: 101, P. 110504 - 110504

Published: Oct. 26, 2022

Language: Английский

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The impact of particulate matters on apoptosis in various organs: Mechanistic and therapeutic perspectives

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 165, P. 115054 - 115054

Published: June 28, 2023

Ecological air contamination is the non-homogenous suspension of insoluble particles into gas or/and liquid fluids known as particulate matter (PM). It has been discovered that exposure to PM can cause serious cellular defects, followed by tissue damage stress. Apoptosis a homeostatic and regulated phenomenon associated with distinguished physiological actions inclusive organ generation, aging, development. Moreover, it proposed deregulation apoptotic performs an active role in occurrence many disorders, such autoimmune disease, neurodegenerative, malignant, human population. Recent studies have shown PMs mainly modulate multiple signaling pathways involved apoptosis, including MAPK, PI3K/Akt, JAK/STAT, NFκB, Endoplasmic Stress, ATM/P53, leading apoptosis dysregulation apoptosis-related pathological conditions. Here, recently published data concerning effect on various organs, particular focus importance component PM-induced toxicity disease development, carefully discussed. review also highlighted therapeutic approaches, small molecules, miRNA replacement therapy, vitamins, PDRN, for treating diseases caused toxicity. Notably, researchers considered medicinal herbs potential treatment due their fewer side effects. So, final section, we analyzed performance some natural products inhibition intervention arising from

Language: Английский

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