Metal–Phenolic Networks for Chronic Wounds Therapy

International Journal of Nanomedicine, Journal Year: 2023, Volume and Issue: Volume 18, P. 6425 - 6448

Published: Nov. 1, 2023

Abstract: Chronic wounds are recalcitrant complications of a variety diseases, with pathologic features including bacterial infection, persistent inflammation, and proliferation reactive oxygen species (ROS) levels in the wound microenvironment. Currently, use antimicrobial drugs, debridement, hyperbaric therapy, other methods clinical for chronic treatment is prone to problems such as resistance, expansion, even exacerbation. In recent years, researchers have proposed many novel materials targeting disease characteristics, among which metal–phenolic networks (MPNs) supramolecular network structures that utilize multivalent metal ions natural polyphenols complexed through ligand bonds. They flexible versatile combination structural forms formations (nanoparticles, coatings, hydrogels, etc.) can be constructed. Functionally, MPNs combine chemocatalytic bactericidal properties well anti-inflammatory antioxidant polyphenol compounds. Together excellent rapid synthesis negligible cytotoxicity, attracted researchers' great attention biomedical fields anti-tumor, anti-bacterial, anti-inflammatory. This paper will focus on composition MPNs, mechanisms wounds, application therapies. Keywords: networks, antimicrobial, antioxidant, scavenging, revascularization

Language: Английский

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Hydrogels dressings based on guar gum and chitosan: Inherent action against resistant bacteria and fast wound closure

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 253, P. 127281 - 127281

Published: Oct. 6, 2023

Language: Английский

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Natural Polymer–Based Hydrogel Dressings for Wound Healing

Advances in Wound Care, Journal Year: 2024, Volume and Issue: unknown

Published: April 16, 2024

Significance: Acute wounds such as severe burns and chronic like diabetic ulcers present a significant threat to human health. Wound dressings made from natural polymers offer inherent properties that effectively enhance wound healing outcomes reduce time. Recent Advances: Numerous innovative hydrogels are being developed translated the clinic successfully treat various types. This underscores substantial potential of in future care market. Economically, annual sales products projected reach $15-22 billion by 2024. Critical Issues: While chitosan-, cellulose-, collagen-based hydrogel currently commercially available, scaling up manufacturing for commercial remains challenging process. Additionally, ensuring sterility stability chemical or biological components comprising critical considerations. Future Directions: In light persistent increase fatalities resulting economic social impacts, well importance educating public about dietary health disease, there should be increased investment new dressings, particularly derived products. With numerous researchers dedicated advancing preclinical hydrogels, holds promise more personalized dressings.

Language: Английский

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Synthesis of bimetallic oxides (SrO-CoO) nanoparticles decorated polyacrylamide hydrogels for controlled drug release and wound healing applications

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 274, P. 133194 - 133194

Published: June 15, 2024

Language: Английский

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Photocatalytic Ag-MOF confers efficient antimicrobial activity to modified polyvinyl alcohol films

Food Bioscience, Journal Year: 2024, Volume and Issue: 61, P. 104959 - 104959

Published: Aug. 23, 2024

Language: Английский

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