Nanofiber Scaffolds as Drug Delivery Systems Promoting Wound Healing

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(7), P. 1829 - 1829

Published: June 26, 2023

Nanofiber scaffolds have emerged as a revolutionary drug delivery platform for promoting wound healing, due to their unique properties, including high surface area, interconnected porosity, excellent breathability, and moisture absorption, well spatial structure which mimics the extracellular matrix. However, use of nanofibers achieve controlled loading release still presents many challenges, with ongoing research exploring how load drugs onto nanofiber without loss activity control in specific spatiotemporal manner. This comprehensive study systematically reviews applications recent advances related drug-laden skin-wound management. First, we introduce commonly used methods preparation, electrostatic spinning, sol-gel, molecular self-assembly, thermally induced phase separation, 3D-printing techniques. Next, summarize polymers preparation utilizing scaffolds. We then review application drug-loaded considering different stages healing acts. Finally, briefly describe stimulus-responsive schemes scaffolds, other exciting systems.

Language: Английский

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Advances in wound dressing based on electrospinning nanofibers

Journal of Applied Polymer Science, Journal Year: 2023, Volume and Issue: 141(1)

Published: Oct. 3, 2023

Abstract In recent years, there has been a significant focus on bioactive dressings suitable for treating chronic and acute wounds. Electrospinning nanofibers are considered advanced dressing options due to their high porosity permeability air water, effective barrier properties against external pathogens, excellent resemblance the extracellular matrix wound healing skin regeneration. This article reviews advancements in application of electrospinning healing. The review begins with an overview process methods. It then explores advantages disadvantages different synthetic natural polymers used preparation dressings. discussed this include collagen, gelatin, silk fibroin, chitosan, hyaluronic acid, sodium alginate. Additionally, delves into commonly like polyvinyl alcohol, chloride, polyethylene lactone, polylactide, polyurethane applications. Furthermore, examines blending create high‐performance also incorporation functional additives, such as antimicrobial agents, growth factors, extracts, expedite tissue repair. conclusion, is emerging technology that provides unique opportunities designing more care products.

Language: Английский

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Chitosan-Based Scaffolds Incorporated with Silver Nanoparticles for the Treatment of Infected Wounds

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(3), P. 327 - 327

Published: Feb. 26, 2024

Bacterial infections are major problems in wound care due to their impact on the retarded process of healing, leading chronic wounds. Most presently utilized dressing products exhibit poor antimicrobial properties. Wound dressings formulated from chitosan have been reported be effective for treating infected wounds, resulting antibacterial properties chitosan. The chitosan-based can further enhanced by incorporating metallic nanoparticles into them, such as silver, zinc, titanium, etc. incorporation silver has widely explored design dressings. promotes accelerated wound-healing processes activity. healing these metal-based is via regulation re-epithelialization and inflammation without affecting viability normal cells. However, there few reports that evaluate infectious animal models prove efficacy. vivo toxicity still needs addressed, revealing need preclinical clinical trials. fabrication incorporated with not fully explored, especially wounds requiring immediate treatment. possible interactions between scaffolds result synergistic effects understood studied. This review provides a comprehensive report outcomes materials loaded managing

Language: Английский

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Synthesis and characterization of a novel TiO2@chitosan/alginate nanocomposite sponge for highly efficient removal of As(V) ions from aqueous solutions: Adsorption isotherm, kinetics, experiment and adsorption mechanism optimization using Box-Behnken design

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 275, P. 133513 - 133513

Published: June 30, 2024

Language: Английский

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Metal nanoparticles and carbohydrate polymers team up to improve biomedical outcomes

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 168, P. 115695 - 115695

Published: Oct. 14, 2023

The convergence of carbohydrate polymers and metal nanoparticles (MNPs) holds great promise for biomedical applications. Researchers aim to exploit the capability matrices modulate physicochemical properties MNPs, promote their therapeutic efficiency, improve targeted drug delivery, enhance biocompatibility. Therefore, understanding various attributes both carbohydrates MNPs is key harnessing them many distinct types carbohydrate-MNP systems confer unique capabilities wound healing, tissue engineering, cancer treatment, even food packaging. Here, we introduce physicochemical/biological discuss potentials shortcomings (alone in combination) We then offer an overview on how they can be utilized outcomes. Last but not least, future perspectives toward application such are highlighted.

Language: Английский

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Resveratrol-Ampicillin Dual-Drug Loaded Polyvinylpyrrolidone/Polyvinyl Alcohol Biomimic Electrospun Nanofiber Enriched with Collagen for Efficient Burn Wound Repair

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 5397 - 5418

Published: June 1, 2024

Background: The healing of burn wounds is a complicated physiological process that involves several stages, including haemostasis, inflammation, proliferation, and remodelling to rebuild the skin subcutaneous tissue integrity. Recent advancements in nanomaterials, especially nanofibers, have opened new way for efficient due burning or other injuries. Methods: This study aims develop characterize collagen-decorated, bilayered electrospun nanofibrous mats composed PVP PVA loaded with Resveratrol (RSV) Ampicillin (AMP) accelerate wound repair. Results: Nanofibers smooth surfaces web-like structures diameters ranging from 200 400 nm were successfully produced by electrospinning. These fibres exhibited excellent vitro properties, ability absorb exudates undergo biodegradation over two-week period. Additionally, these nanofibers demonstrated sustained controlled release encapsulated through studies. zone inhibition (ZOI) PVP-PVA-RSV-AMP against Staphylococcus aureus ( S. aureus) Escherichia coli E. ) was found 31± 0.09 mm 12± 0.03, respectively, which significantly higher as compared positive control. Similarly, biofilm confirmed significant reduction formation biofilms nanofiber-treated group both . X-ray diffraction (XRD) Fourier transform infrared spectroscopy (FTIR) analysis proved encapsulation RSV AMP into their compatibility. Haemolysis assay (%) showed no haemolysis (less than 5%) groups, cytocompatibility red blood cells (RBCs). Cell viability cell adhesion on HaCaT increased indicating its biocompatibility well non-toxic properties. Results in-vivo experiments model potential rats H&E-stained images also improved collagen synthesis nanofibers-treated groups evidenced Masson-trichrome staining. ELISA clearly indicated downregulation TNF-alpha IL-6 inflammatory biomarkers after treatment day 10. Conclusion: AMP-loaded nanofiber mats, developed this study, expedite multifaceted approach. Keywords: electrospinning, nanofiber, resveratrol, ampicillin, healing,

Language: Английский

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Electrospun Chitosan/Polylactic Acid Nanofibers with Silver Nanoparticles: Structure, Antibacterial, and Cytotoxic Properties

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Electrospinning, a technique for creating fabric materials from polymer solutions, is widely used in various fields, including biomedicine. The unique properties of electrospun fibrous membranes, such as large surface area, compositional versatility, and customizable porous structure, make them ideal advanced biomedical applications like tissue engineering wound healing. By considering the high biocompatibility well-known regenerative potential polylactic acid (PLA) chitosan (CH), well versatile antibacterial effect silver nanoparticles (AgNPs), this study explores efficacy, adhesive properties, cytotoxicity membranes with nanofibrous structure varying concentrations AgNPs. Silver incorporated at 25-50 μg/mL or above significantly enhanced effectiveness, especially against Staphylococcus aureus Escherichia coli. Biocompatibility assessments using umbilical cord mesenchymal stem cells demonstrated nontoxic nature an AgNP concentration 12.5 μg/mL, underscoring their applications. This provides valuable insights into developing effective antimicrobial coatings uses, healing patches constructs soft replacement.

Language: Английский

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New insights into chitosan-Ag nanocomposites synthesis: Physicochemical aspects of formation, structure-bioactivity relationship and mechanism of antioxidant activity

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140077 - 140077

Published: Jan. 1, 2025

Language: Английский

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Synthesis and characterization of functionalized yttrium metal-organic frameworks encapsulated onto bi-polymers for effective removal of As(III); adsorption isotherms, kinetic, and optimization via Box-Behnken design

Materials Today Communications, Journal Year: 2025, Volume and Issue: unknown, P. 112244 - 112244

Published: March 1, 2025

Language: Английский

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Electrospun fibers for the treatment of skin diseases

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 363, P. 621 - 640

Published: Oct. 12, 2023

Skin diseases are among the most common in global population and with growth of aging population, they represent an increasing burden to healthcare systems worldwide. Even though rarely life-threatening, suffering for those affected is high due visibility physical discomfort related these diseases. Typical symptoms skin include inflamed, swollen or itchy skin, therefore, there a demand effective therapy options. In recent years, electrospinning has attracted considerable interest field drug delivery. The technique allows producing multifunctional drug-loaded fibrous patches from various natural synthetic polymers fiber diameters nano- micrometer range, suitable treatment wide variety great potential electrospun not only lies their tunable release properties possibility entrap therapeutic compounds, but also provide mechanical protection impaired area, exhibit surface allow gas exchange, absorb exudate porous structure cytocompatible biodegradable. case wound healing, cell adhesion promoted resemblance fibers native extracellular matrix. This review gives overview applications therapy. addition bacterial, diabetic burn wounds, focus placed on inflammatory such as atopic dermatitis psoriasis, options cancer, acne vulgaris herpes labialis discussed. While we aim emphasize this paper, highlight challenges limitations current research field.

Language: Английский

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