ChemistrySelect,
Journal Year:
2024,
Volume and Issue:
9(38)
Published: Oct. 1, 2024
Abstract
Cationic
cetyltrimethylammonium
(CTAB)
is
an
effective
and
common
intercalator
for
interlayered
modification
in
layered
materials,
while
its
biotoxicity
remains
issue.
To
improve
biosafety
biocompatibility
of
the
drug
delivery
system,
nontoxic
chitosan
(CS)
was
introduced
into
CTAB‐modified
kanemite
(Ka‐CTAB).
Accordingly,
obtained
Ka‐CTAB/CS
further
used
as
a
carrier
methotrexate
(MTX).
Various
characterizations
were
employed
to
investigate
system
based
on
Ka‐CTAB/CS.
Results
revealed
that
loading
capacity
MTX
about
13.47%,
exhibited
slow
sustained
release
drugs
either
phosphate
buffer
solution
(pH
=
7.4)
or
HCl
1.35).
The
introduction
CS
not
only
replaced
part
CTAB
composition
but
also
prevented
molecules
falling
off
during
drug‐releasing
process.
In
methyl
orange
dye
assay,
concentration
free
shed
from
low
8.09
×
10
−7
mol/L
after
24
h.
vitro
cell
viability
assay
using
HepG2
cells,
lower
cytotoxicity
compared
previous
Ka‐CTAB.
Nanomedicine,
Journal Year:
2024,
Volume and Issue:
19(7), P. 633 - 651
Published: March 1, 2024
Nanomedicine
has
opened
up
new
avenues
for
cancer
treatment
by
enhancing
drug
solubility,
permeability
and
targeted
delivery
to
cells.
Despite
its
numerous
advantages
over
conventional
therapies,
nanomedicine
may
exhibit
off-target
distribution,
harming
nontarget
regions.
The
increased
permeation
retention
effect
of
in
tumor
sites
also
limitations,
as
abnormal
vasculature,
dense
stroma
structure
altered
microenvironment
(TME)
result
limited
intratumor
distribution
therapeutic
failure.
However,
TME-responsive
exhibited
immense
potential
efficient,
safe
precise
therapeutics
utilizing
stimuli
specific
the
TME.
This
review
discusses
mechanistic
aspects
various
biopolymers
their
application
developing
types
nanomedicine.
Archiv der Pharmazie,
Journal Year:
2025,
Volume and Issue:
358(3)
Published: March 1, 2025
Abstract
Nowadays,
diseases
have
a
high
rate
of
incidence
and
mortality
worldwide.
On
the
other
side,
drawbacks
conventional
modalities
in
suppression
encountered
serious
problematic
issues
for
health
human
beings.
For
instance,
although
various
approaches
been
applied
treatment
cancer,
it
has
an
ever‐increasing
throughout
globe.
Thus,
there
is
fundamental
requirement
development
breakthrough
technologies
inhibition
diseases.
Hyaluronic
acid
(HA)
one
most
practical
biopolymers
HA
lots
potential
physicochemical
(like
rheological,
structural,
molecular
weight,
ionization,
etc.)
biomedical
properties
(bioavailability,
biocompatibility,
CD44
targeting
signaling
pathways,
components
biological
organs,
mucoadhesion,
immunomodulation,
etc.),
which
made
candidate
tools
pharmaceutical
sciences.
The
ease
surface
modification
(carboxylation,
amidation,
hydroxylation,
esterification),
bioavailability
synthesis
routes,
administration
routes
are
considered
as
merits
HA‐based
vehicles.
These
mucopolysaccharide
materials
considerably
developed
use
drug
delivery
systems
(DDSs),
cancer
therapy,
wound
healing,
antiaging,
tissue
engineering.
This
review
summarizes
advantages
DDS
scaffolds
Cancers,
Journal Year:
2023,
Volume and Issue:
15(16), P. 4194 - 4194
Published: Aug. 21, 2023
Mangiferin
(MGF),
a
xanthone
derived
from
Mangifera
indica
L.,
initially
employed
as
nutraceutical,
is
now
being
explored
extensively
for
its
anticancer
potential.
Scientists
across
the
globe
have
this
bioactive
managing
variety
of
cancers
using
validated
in
vitro
and
vivo
models.
The
potential
biomolecule
on
well-established
breast
cancer
cell
lines
such
MDA-MB-23,
BEAS-2B
cells
MCF-7
closer
to
many
approved
synthetic
agents.
However,
solubility
bioavailability
are
main
challenges,
oral
reported
be
less
than
2%,
aqueous
also
0.111
mg/mL.
Nano-drug
delivery
systems
attempted
deliver
drugs
at
desired
site
rate
amounts.
Many
researchers
various
nanotechnology-based
approaches
provide
effective
safe
mangiferin
therapy.
Nanoparticles
were
used
carriers
encapsulate
mangiferin,
protecting
it
degradation
facilitating
cells.
They
enhance
bioavailability,
safety
efficacy
very
drug
approaches.
present
review
focuses
origin
structure
elucidation
derivatives
benefits
bioactive.
offers
insight
into
delivery-related
challenges
applications
nanosized
forms
against
cancer.
use
relatively
new
deep-learning
approach
solve
pharmacokinetic
issues
has
been
discussed.
critically
analyzes
future
hope
therapeutic
agent
management.
ACS Omega,
Journal Year:
2023,
Volume and Issue:
8(43), P. 40494 - 40507
Published: Oct. 20, 2023
Stearoyl
chitosan
(SC),
derived
from
the
acylation
of
chitosan,
contributes
to
efficiency
drug
delivery
systems
because
its
structure,
which
accommodates
in
a
particle.
Nonetheless,
role
chemotherapy
has
been
largely
unexplored.
The
present
study
involves
synthesis
stearoyl
through
reaction
depolymerized
with
chloride
under
mild
conditions.
resulting
compound
was
subjected
structural
analysis
utilizing
Fourier-transform
infrared
(FTIR)
spectroscopy,
1H
NMR,
and
X-ray
diffraction
(XRD)
spectroscopy.
dispersion
SC
molecules
phosphate-buffered
saline
(PBS)
forms
nanoparticles.
best
solution
achieved
at
1:60
chitosan-to-stearoyl
weight
ratio.
Three
antimetabolite
drugs,
methotrexate,
pemetrexed,
raltitrexed,
were
selected
examine
loading
efficacy
SC.
Pemetrexed
had
highest
drug-loading
value
36.8%
among
three
antimetabolites
incorporated
into
SC,
along
an
encapsulation
85.1%.
size
loaded
ranged
225
369
nm,
their
spherical
form
verified
via
transmission
electron
microscope.
vitro
release
showed
that
demonstrated
controlled
release,
suggesting
nanoparticles
have
significant
promise
as
strategy
for
chemotherapy.
