International Journal of Dairy Technology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 10, 2024
Lactiplantibacillus
plantarum
M660
(M660)
was
isolated
from
the
human
milk
of
a
healthy
mother.
could
survive
simulated
gastrointestinal
conditions
without
haemolytic
and
biogenic
amine‐producing
ability.
The
faecal
water
content
reduced,
recoveries
cecum
intestinal
barrier
were
accelerated
by
in
antibiotic‐associated
diarrhoea
model.
In
constipation
model,
enhanced
motility,
improved
serum
neurotransmitter
levels,
reduced
colonic
injury.
Analysis
gut
microbiota
showed
that
increased
abundance
potentially
beneficial
bacteria
decreased
number
pathogenic
bacteria.
Overall,
be
probiotic
candidate
to
promote
infant
health.
Food & Function,
Journal Year:
2024,
Volume and Issue:
15(3), P. 1265 - 1278
Published: Jan. 1, 2024
Dietary
nobiletin
alleviated
antibiotic-associated
gut
dysbiosis
by
maintaining
the
balance
of
intestinal
microbiota
and
metabolism
to
enhance
barrier
function.
Antibiotics,
Journal Year:
2025,
Volume and Issue:
14(2), P. 138 - 138
Published: Feb. 1, 2025
Background/Objectives:
Drug-induced
dysbiosis,
particularly
from
antibiotics,
has
emerged
as
a
significant
contributor
to
chronic
diseases
by
disrupting
gut
microbiota
composition
and
function.
Plant-derived
secondary
metabolites,
such
polysaccharides,
polyphenols,
alkaloids,
saponins,
show
potential
in
mitigating
antibiotic-induced
dysbiosis.
This
review
aims
consolidate
evidence
preclinical
studies
on
the
therapeutic
effects
of
metabolites
restoring
microbial
balance,
emphasizing
their
mechanisms
efficacy.
Methods:
A
narrative
was
conducted
using
PubMed,
Scopus,
Web
Science.
Studies
were
selected
based
specific
inclusion
criteria,
focusing
animal
models
treated
with
for
The
search
terms
included
“gut
microbiota”,
“antibiotics”,
“secondary
metabolites”.
Data
extraction
focused
alterations,
metabolite-specific
effects,
action.
Relevant
findings
systematically
analyzed
summarized.
Results:
Secondary
demonstrated
diverse
impact
dysbiosis
modulating
composition,
reducing
inflammation,
supporting
host
biological
markers.
Polysaccharides
polyphenols
restored
Firmicutes/Bacteroidetes
ratio,
increased
beneficial
taxa
Lactobacillus
Bifidobacterium,
suppressed
pathogenic
bacteria
like
Escherichia-Shigella.
Metabolites
triterpenoid
saponins
enhanced
barrier
integrity
upregulating
tight
junction
proteins,
while
alkaloids
reduced
inflammation
proinflammatory
cytokines
(e.g.,
TNF-α,
IL-1β).
These
also
improved
short-chain
fatty
acid
production,
which
is
crucial
systemic
health.
While
primary
focus,
other
drug
classes
PPIs,
metformin)
require
further
investigation.
Conclusions:
promise
managing
improving
Future
research
should
explore
applicability
types
drug-induced
validate
human
enhance
clinical
relevance.
