Developments of Core/Shell Chitosan-Based Nanofibers by Electrospinning Techniques: A Review

Fibers, Journal Year: 2024, Volume and Issue: 12(3), P. 26 - 26

Published: March 12, 2024

This review is focused on the recent development of various chitosan-based nanofibers (membranes, patches, mats, and scaffolds) that have been designed into core shell structures using emulsion coaxial electrospinning techniques. Chitosan, a promising polysaccharide derived from natural sources, holds potential for diverse applications, including nanofiber production, aimed at fostering sustainability. Core/shell offer appealing features, drug encapsulation sustained release capabilities, with higher efficiency than uniaxial fibers. The fabrication core/shell nanofibers, co-spinning agents spinning parameters, such as voltage, needle size, flow rate, distance tip to collector, temperature, humidity, summarized in this work. also explores updated applications fields, textiles, medical dressings, systems, filtration membranes, food packaging. It highlights current advancements produced via innovative insights presented literature challenges associated these sustainable materials are thoroughly examined, offering valuable contributions field.

Language: Английский

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Recent progress in biopolymer-based electrospun nanofibers and their potential biomedical applications: A review

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 293, P. 139426 - 139426

Published: Jan. 1, 2025

Language: Английский

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Calcium Hydroxyapatite in Its Different Forms in Skin Tissue Repair: A Literature Review

Surgeries, Journal Year: 2024, Volume and Issue: 5(3), P. 640 - 659

Published: Aug. 9, 2024

The skin is crucial for homeostasis and body defense, requiring quick healing to maintain internal balance. Initially used bone repair, calcium hydroxyapatite (HAp) now being studied soft tissue engineering. This literature review investigated HAp’s role in repair through searches on PubMed, Scopus (Elsevier), Science Direct, Springer Link, Google Scholar databases without time restrictions, using keywords “hydroxyapatite AND wound” repair”. Inclusion criteria encompassed vivo studies humans animals, English publications, full access, sufficient data repair. Exclusions included duplicates, unrelated articles, editor letters, reviews, comments, conference abstracts, dissertations, theses. Out of the 472 articles initially identified, 139 met inclusion criteria, with 21 focusing HAp Findings indicate that nano-HAp regeneration are promising, especially when combined other biomaterials, offering antimicrobial anti-inflammatory benefits stimulating angiogenesis. suggests their potential application dermatology, surgery, dentistry, extending versatility from hard tissues enhancing critical properties accelerating healing.

Language: Английский

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Pluronic F127-chitosan modified magnesium oxide hybrid nanomaterials prepared via a one-pot method: Potential uses in antibacterial and anticancer agents

Surfaces and Interfaces, Journal Year: 2023, Volume and Issue: 42, P. 103327 - 103327

Published: Aug. 25, 2023

Language: Английский

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Multifunctional Hydroxyapatite Coated with Gallium Liquid Metal‐Based Silver Nanoparticles for Infection Prevention and Bone Regeneration

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

Abstract Implant‐associated infections and inflammation during pre‐ post‐operative procedures remain significant challenges that reduce implant longevity. In this study, the uniques bioactive coatings derived from silver‐gallium liquid metal particles (Ag‐GaNPs) deposited uniformly over HAp scaffold (HAp‐Ag‐GaNPs) are developed. The HAp‐Ag‐GaNPs exhibit strong antimicrobial activities against Gram‐negative Pseudomonas aeruginosa , Gram‐positive Staphylococcus aureus ( S. ), drug‐resistant bacteria such as methicillin‐resistant persistent like small colony variant of . antibacterial mechanisms multifaced, including reactive oxygen species within cells, leading to damage leakage cytosolic contents reduced ATP levels. synchrotron macro attenuated total reflectance – Fourier transform infrared microspectroscopy is utilized understand influence on lipids, proteins, nucleic acids pathogenic bacteria. Proteomic analysis reveals disrupt critical bacterial processes, DNA replication, RNA transcription, protein synthesis, energy metabolism, alongside inducing oxidative stress membrane in addition, vivo studies demonstrate colonization enhanced tissue integration at sites treated with HAp‐Ag‐GaNPs, further supporting their dual functionality. findings highlight potential a next‐generation biomaterial osteogenic properties for clinical applications orthopedic implants.

Language: Английский

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Electrospun composite nanofibers for wound healing: synthesis, characterization, and clinical potential of biopolymer-based materials

Discover Materials, Journal Year: 2024, Volume and Issue: 4(1)

Published: Dec. 20, 2024

The recent advancements in nanotechnology have significantly impacted wound healing, particularly through the development of electrospun nanofibers (NFs). This review summarizes research on NFs made from chitosan, gelatin, curcumin, and rutin, focusing their potential for healing applications. Chitosan is noted its antimicrobial biocompatible properties, gelatin excellent biocompatibility biodegradability, curcumin rutin strong antioxidant anti-inflammatory effects. Electrospinning employed to produce these with controlled diameters morphologies. discusses preparation methods, optimal electrospinning parameters, challenges like solution viscosity environmental conditions. It also includes an assessment using SEM, TEM, FTIR, XRD, tensile testing, DSC evaluate morphology, chemical composition, mechanical thermal biodegradability. In vitro vivo testing NFs' efficacy, including biocompatibility, activity, hemocompatibility, closure rates animal models. highlights that NF combining show enhanced due synergistic which promote cell proliferation, reduce inflammation, prevent infection. Despite promising results, optimizing synthesis process ensuring consistent clinical performance remain. Further needed address advance application NFs. aims guide future contribute more effective wound-healing therapies.

Language: Английский

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Protective potential of naringenin and its nanoformulations in redox mechanisms of injury and disease

Heliyon, Journal Year: 2023, Volume and Issue: 9(12), P. e22820 - e22820

Published: Nov. 25, 2023

Increasing evidence suggests that elevated intracellular levels of reactive oxygen species (ROS) play a significant role in the pathogenesis many diseases. Increased ROS can lead to oxidation lipids, DNA, and proteins, contributing cellular damage. Hence, maintenance redox hemostasis is essential. Naringenin (NAR) flavonoid included flavanones subcategory. Various pharmacological actions have been ascribable this phytochemical composition, including antioxidant, anti-inflammatory, antibacterial, antiviral, antitumor, antiadipogenic, neuro-, cardio-protective activities. This review focused on underlying mechanism responsible for antioxidative stress properties NAR its' nanoformulations. Several lines vitro vivo investigations suggest effects its nanoformulation their target cells via modulating signaling pathways. These nanoformulations include nanoemulsion, nanocarriers, solid lipid nanoparticles (SLN), nanomicelle. also highlights several beneficial health human diseases brain disorders, cancer, rheumatoid arthritis, small intestine injuries. Employing improve pharmacokinetic consequently efficiency by reducing limitations, such as low bioavailability. The protective against oxidative may be linked modulation Nrf2-heme oxygenase-1, NO/cGMP/potassium channel, COX-2, NF-κB, AMPK/SIRT3, PI3K/Akt/mTOR, BDNF, NOX, LOX-1 Understanding behind facilitate drug development treatment stress-related disorders.

Language: Английский

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Chitosan/PVA reinforced boron/strontium multi-substituted hydroxyapatite-based biocomposites: Effects of synthesis pH and coating on the physicochemical, mechanical, and in vitro biological properties of scaffolds

Materials Today Chemistry, Journal Year: 2023, Volume and Issue: 35, P. 101865 - 101865

Published: Dec. 29, 2023

Language: Английский

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Application of Drug Delivery System Based on Nanozyme Cascade Technology in Chronic Wound

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(32)

Published: Oct. 14, 2024

Abstract Chronic wounds are characterized by long‐term inflammation, including diabetic ulcers, traumatic etc., which provide an optimal environment for bacterial proliferation. At present, antibiotics the main clinical treatment method chronic wound infections. However, overuse of may accelerate emergence drug‐resistant bacteria, poses a significant threat to human health. Therefore, there is urgent need develop new therapeutic strategies Nanozyme‐based antimicrobial therapy (NABT) emerging strategy with broad‐spectrum activity and low drug resistance compared traditional antibiotics. NABT has shown great potential as catalyzing generation reactive oxygen species (ROS) its enzyme‐like catalytic properties, producing powerful bactericidal effect without developing resistance. cascade technology offers approach infection control, effectively improving efficacy activating cascades against cell membranes intracellular DNA while minimizing side effects. it worth noting that this still in early stages research. This article comprehensively reviews classification, current methods infection, different types nanozymes, application nanozyme reaction therapy, future challenges prospects.

Language: Английский

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Recent developments in green synthesis of hydroxyapatite nanocomposites: relevance to biomedical and environmental applications

Green Chemistry Letters and Reviews, Journal Year: 2024, Volume and Issue: 17(1)

Published: Dec. 2, 2024

Hydroxyapatite (HAP) is a ceramic biomaterial admired with an excellent preference in the biomedical fields as it possesses unique properties and their similarity chemical compositions human bones. Thus, preparation of HAP using wide variety methods under diverse reaction conditions has gained significant interest recent times. In this context, research shifted toward designing green synthesis routes, which avoids use toxic chemicals explores moderate operating conditions. These nanocomposites constituted by nanoparticles (NPs) synthesized via have remarkable biocompatibility, antimicrobial nature, wound healing, osteointegration well environmental applications. peculiar combination HAP, nanotechnology, exciting field that unwrapped new avenues for problems related to in-vivo therapies. focused review article, HAPs HAPs-based composites diversified sources are discussed different The specific insights into formation mechanisms followed relevant application materials medical domains presented. Finally, key issues development perspectives HAP-based applications also emphasized.

Language: Английский

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