Transdermal delivery of resveratrol loaded solid lipid nanoparticle as a microneedle patch: a novel approach for the treatment of Parkinson’s disease

Drug Delivery and Translational Research, Journal Year: 2024, Volume and Issue: unknown

Published: June 29, 2024

Language: Английский

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Development of Pluronic-Based Micelles from Palm Oil Bioactive Compounds Incorporated by a Dissolvable Microarray Patch to Enhance the Efficacy of Atopic Dermatitis Therapy

Molecular Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

The high content of vitamin E, including tocopherols and tocotrienols (TCF-TTE), in palm oil (Elaeis guineensis) has made it a promising candidate for the alternative treatment atopic dermatitis (AD). However, limited solubility TCF-TTE restricted its therapeutic efficacy. In this study, pluronic-based micelles (MCs) encapsulating oil-derived were formulated with dissolvable microarray patch-micelles (DMP-MC) using carboxymethyl cellulose (CMC) synthesized from empty fruit bunches to optimize delivery AD. MC was prepared direct dissolution method Pluronic F68 F127. results showed that increased TCF-TTE, which further confirmed by an vitro study where 90.23 ± 2.07% TCF 4.56 1.36% TTE released compared unencapsulated extract. Furthermore, CMC biopolymers integrated into DMP-MC polyvinylpyrrolidone (PVP) exhibited favorable physical properties, such as mechanical strength penetration ability. also better platform lower permeation, indicating higher retention localized effects on AD skin than cream-MC. Additionally, dermatokinetic profile parameters significant improvement. mean residence time (MRT) parameter indicated retained longer times 19.28 0.02 h 20.68 0.01 h. Moreover, vivo revealed could relieve symptoms more rapidly oral doses cream-MC, proved be efficient. no tissue destruction (granulation fibrosis) rats treated seventh day. Therefore, successfully developed formula formulation CMC, potentially improve AD's

Language: Английский

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Nanomaterials-incorporated polymeric microneedles for wound healing applications

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 659, P. 124247 - 124247

Published: May 22, 2024

Language: Английский

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Recent advances in the development of chitosan/hyaluronic acid-based hybrid materials for skin protection, regeneration, and healing: A review

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 279, P. 135357 - 135357

Published: Sept. 6, 2024

Language: Английский

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Recent advances in drug delivery systems based on natural and synthetic polymes for treating obesity

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 260, P. 129311 - 129311

Published: Jan. 11, 2024

Language: Английский

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Advances in microneedles-based drug delivery system on promoting wound healing

Journal of Drug Delivery Science and Technology, Journal Year: 2023, Volume and Issue: 90, P. 105163 - 105163

Published: Nov. 14, 2023

Language: Английский

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A Synergistic Microemulsion Approach with Cetyl Myristoleate and Hyaluronic Acid for Enhanced Osteoarthritis Therapy: In Vitro and In Vivo Evaluation

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: 106, P. 106694 - 106694

Published: Feb. 6, 2025

Language: Английский

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Hyaluronic acid-based hesperidin nanostructured lipid carriers loaded dissolving microneedles: A localized delivery approach loaded for the management of obesity

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140948 - 140948

Published: Feb. 1, 2025

Language: Английский

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Chitosan Oligosaccharides Prevent Alcohol-Induced Liver Disease by Attenuating Inflammation and Oxidative Stress

Marine Drugs, Journal Year: 2025, Volume and Issue: 23(3), P. 134 - 134

Published: March 19, 2025

Alcoholic liver disease (ALD) is a disorder resulting from excessive alcohol intake, and currently, there are no therapeutics approved by the FDA for its treatment. This study investigates protective effects underlying pharmacological mechanisms of two chitosan oligosaccharides, COST (MW ≤ 1000 Da) COSM 3000 Da), in mitigating alcohol-induced (ALD). In animal models, we evaluated changes ALD following treatment with COSM. Histopathological analysis revealed that both interventions mitigated hepatic steatosis inflammatory infiltration. Additionally, these compounds reduced various markers injury, enhanced antioxidant enzyme levels, significantly improved function. Western blot demonstrated markedly decreased expression metabolic CYP2E1, activated Keap-1/Nrf-2/HO-1 pathway, restrained NF-κB MAPK pathways. an vitro model hepatocyte L02 exhibited on hepatocytes, corroborating findings studies. Collectively, vivo experiments confirmed can reduce oxidative damage, enhance capacity, ameliorate damage liver, thereby attenuating injury. Notably, slightly superior efficacy compared to COST.

Language: Английский

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Transdermal microneedle patches as a promising drug delivery system for anti-obesogenic molecules

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: June 11, 2024

Obesity, characterized by excessive storage of lipids, has become a global pandemic with high incidence levels, and its forecast is not encouraging. Currently, there are different strategies to treat obesity; however, these conventional methods have various limitations. Lifestyle changes may result in poor outcomes due the complexity obesity causes, pharmaceutic treatments produce severe side effects, bariatric surgery highly invasive. In search for alternative fight obesity, transdermal drug delivery systems anti-obesogenic molecules gained particular attention. However, diffusion through skin main drawback characteristics layers skin, principally

Language: Английский

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