Regulatory effects of Poria cocos polysaccharides on gut microbiota and metabolites: Evaluation of prebiotic potential DOI Creative Commons
Xu Zhou, Yangyou Li, Yuhan Yang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 20, 2024

Abstract Dietary polysaccharides have the function of regulating gut microbiota and metabolites, can serve as an important source functional foods. This study aimed to analyze regulation poria cocos on structure metabolism human through in vitro fecal fermentation model. The results showed that Poria be utilized by microbiota, resulting in a significant decrease pH increase concentration short-chain fatty acids. Additionally, relative abundance beneficial bacteria such Lactobacillus, Bifidobacterium increased, while harmful Escherichia-Shigella, Bilophila decreased. Furthermore, had positive effect microbial significantly up-regulating metabolites L-cystine, etelcalcetide. These highlight role maintaining intestinal health indicate their potential prebiotics food industry.

Language: Английский

Characterization and prebiotic potential of polysaccharides from Rosa roxburghii Tratt pomace by ultrasound-assisted extraction DOI
Zhenghao Chen, Xiaohui Yuan, Tingting Tu

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 268, P. 131910 - 131910

Published: April 26, 2024

Language: Английский

Citations

15
Structural Characterization and Anti-Gouty Nephropathy Potential of Polysaccharides from Atractylodes chinensis DOI Creative Commons
Chen Xue,

Runan Jia,

Kai Zhang

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(4), P. 757 - 757

Published: Feb. 7, 2025

Polysaccharides derived from Atractylodes chinensis (DC.) Koidz. (ACP), a traditional Chinese medicine, were extracted and analyzed for their structural characteristics anti-gouty nephropathy (GN) activity. Sprague-Dawley (SD) rats divided into six groups: control, model, positive three treatment groups (ACP-60-L, ACP-60-M, ACP-60-H). Treatment significantly reduced inflammatory responses renal damage, as evidenced by decreased levels of uric acid (UA), creatinine (Cr), blood urea nitrogen (BUN), alongside modulation NOD-like receptor protein 3 (NLRP3) expression in tissues. ACP-60 was fractionated polysaccharides, including ACP-60-A (Mw 9.18 kDa), ACP-60-B 58.21 ACP-60-C 109.01 kDa) using DEAE-52 cellulose column chromatography. Monosaccharide analysis revealed that predominantly comprised fructose (Fru) glucose (Glc), contained rhamnose (Rha), galactose (Gal), Fru, mannose (Man), included Man, Gal, Rha xylose (Xyl). In vitro studies HK-2 cells confirmed the anti-GN activity all fractions, with demonstrating highest efficacy. Structural elucidation identified its main glycosidic linkages →1)-β-Fruf-(2→ backbone α-Glcp-(1→ β-Fruf-(2→ branches. The underlying mechanism ACP-60-A’s is associated inhibition NLRP3 inflammasome signaling pathway, suppression downstream factor release, downregulation NLRP3, ASC, Caspase-1 expression. Further demonstrated superior attributable to lower molecular weight, specific monosaccharide composition, unique bond arrangement. shows potential increased efficacy through purification or modification, laying groundwork developing novel therapeutic agents GN.

Language: Английский

Citations

1
Stir-frying duration modulates structural characterization and functional properties of Atractylodes macrocephala polysaccharides DOI
Wei Li, Xiaoxiao Wang, Xiuyan Sun

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 306, P. 141489 - 141489

Published: Feb. 27, 2025

Language: Английский

Citations

1
Differential characteristics of chemical composition, fermentation metabolites and antioxidant effects of polysaccharides from Eurotium Cristatum and Fu-brick tea DOI

Zhengwei Tan,

Pinglian Yu,

Haoyan Zhu

et al.

Food Chemistry, Journal Year: 2024, Volume and Issue: 461, P. 140934 - 140934

Published: Aug. 22, 2024

Language: Английский

Citations

6
The effect of EGCG/tyrosol-loaded chitosan/lecithin nanoparticles on hyperglycemia and hepatic function in streptozotocin-induced diabetic mice DOI
Ali Es‐haghi, Mozhgan Soltani, Masoud Homayouni Tabrizi

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 267, P. 131496 - 131496

Published: April 16, 2024

Language: Английский

Citations

4
Structural characterization of the polysaccharides from Atractylodes chinensis (DC.) Koidz. and the protective effection against alcohol-induced intestinal injury in rats DOI

Jin Sun,

Yuxin Jiang, Bo Wang

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 136641 - 136641

Published: Oct. 18, 2024

Language: Английский

Citations

4
Research progress on extraction, separation, structure, and biological activities of polysaccharides from the genus Atractylodes: A review DOI
Fei Lin, Yang Xu, Bin Liu

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 283, P. 137550 - 137550

Published: Nov. 13, 2024

Language: Английский

Citations

4
Bridging dietary polysaccharides and gut microbiome: how to achieve precision modulation for gut health promotion DOI

Xihao Sun,

Zhangming Pei,

Hongchao Wang

et al.

Microbiological Research, Journal Year: 2025, Volume and Issue: 292, P. 128046 - 128046

Published: Jan. 2, 2025

Language: Английский

Citations

0
Fecal fermentation of lentinan and its effect on gut microbiota and metabolites DOI Creative Commons
Yuhan Yang, Xu Zhou, Botao Wang

et al.

International Journal of Food Science & Technology, Journal Year: 2025, Volume and Issue: 60(1)

Published: Jan. 1, 2025

Abstract Lentinan (LNT) is a polysaccharide from Shiitake mushrooms that has significant effects regarding antioxidant, hypoglycemic, anti-inflammatory activities, etc., and this effect influenced by the human intestinal flora. However, interactions between LNT microorganisms, their metabolic processes, remain unclear. In study, fermentation characteristics of its on flora metabolites were studied in vitro fermentation. Our results indicated was effectively utilised microbiota, utilisation rate 62.7 ± 3.0% after for 48 hr. The concentrations short-chain fatty acids (mainly acetic acid propionic acid) increased to 4.157 0.197 5.847 0.283 mM, respectively. also relative abundance beneficial bacteria, such as Bifidobacterium Parabacteroides, while reducing harmful bacteria like Veillonella Klebsiella. Metabolomics microbial correlation analysis revealed catabolism accompanied amino catabolism, especially alanine, aspartic acid, glutamate, biosynthesis adenosine 5’-monophosphate, etc. These findings suggest can support gut health demonstrates potential prebiotic.

Language: Английский

Citations

0
Enzyme-Microwave Assisted Extraction of Polysaccharides from the Adventitious Root of Atractylodes Chinensis and Evaluation of Hypoglycemic Potential DOI

Yulin Pang,

Jianing Liu, Liuyang Yao

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0