Chitosan-based nanofibrous scaffolds for biomedical and pharmaceutical applications: A comprehensive review

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 264, P. 130683 - 130683

Published: March 6, 2024

Language: Английский

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Advances in chitosan-based blends as potential drug delivery systems: A review

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 273, P. 132916 - 132916

Published: June 5, 2024

Language: Английский

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Synthesis of novel magnesium ferrite Schiff base chitosan nanocomposite for efficient removal of pb(II) ions from aqueous media

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 4, 2025

In this study, a novel MgFe2O4-Schiff base-chitosan nanocomposite was synthesized using straightforward crosslinking method. The synthesis involved integrating MgFe2O4 nanoparticles with modified chitosan through Schiff base formed by the reaction between terephthalaldehyde and aminopyrazine. A comprehensive characterization performed, including X-ray diffraction analysis, which verified crystalline structure successful incorporation of MgFe2O into chitosan-Schiff matrix. Scanning electron microscopy revealed distinct surface morphology, characterized rough, non-uniform alignment resulting from strong interactions Additionally, energy-dispersive analysis elemental composition nanocomposite, revealing peaks corresponding to carbon, nitrogen, oxygen, magnesium, iron. exhibited outstanding performance as nanoadsorbent for efficient removal Pb(II) ions aqueous media electrostatic attraction complexation mechanisms, achieving maximum adsorption capacity 290.7 mg g-1. process determined be spontaneous, endothermic, chemically driven, aligning well Langmuir isotherm model pseudo-second-order kinetics. optimal conditions were pH 5.5, contact time 100 min, temperature 328 K. Furthermore, demonstrated excellent recyclability, retaining over 94.8% its initial efficiency after five consecutive adsorption-desorption cycles. This study highlights nanocomposite's potential an eco-friendly, cost-effective, highly material practical applications in water treatment, addressing urgent need sustainable solutions heavy metal contamination.

Language: Английский

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Polymer hydrogels: Classification and recent advances

Journal of Macromolecular Science Part A, Journal Year: 2024, Volume and Issue: 61(5), P. 265 - 288

Published: March 19, 2024

Hydrogels comprise of a group crosslinked hydrophilic polymeric materials which are capable absorbing and holding large quantities water in their three-dimensional network structure without undergoing dissolution. More importantly, the ability 'smart' hydrogels to respond certain environmental changes e.g. pH, heat, light, magnetic field, biomolecules have set them apart as unique class materials. A combination several such useful properties resulted tremendous progress toward development advanced hydrogel-based materials, is evident from an explosive amount research publications available this area over last few decades. Owing particularly biocompatibility biodegradability, become material prime importance context wide range applications starting simple contact lenses more complex ones tissue repair, drug delivery, sensors, 3D bioprinting, soft robotics agriculture. This review includes i) overview its classifications based on source, structure, crosslinking mechanism stimuli responsiveness, ii) detailed discussion some most works being carried out field years smart that need hour, domain biomedical applications.

Language: Английский

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Recent advances in polysaccharide-based drug delivery systems for cancer therapy: a comprehensive review

Artificial Cells Nanomedicine and Biotechnology, Journal Year: 2024, Volume and Issue: 52(1), P. 564 - 586

Published: Dec. 5, 2024

Cancer has a high rate of incidence and mortality throughout the world. Although several conventional approaches have been developed for treatment cancer, such as surgery, chemotherapy, radiotherapy thermal therapy, they remarkable disadvantages which result in inefficient cancer. For example, immunogenicity, prolonged treatment, non-specificity, metastasis cost are considered major drawbacks chemotherapy. Therefore, there is fundamental requirement development breakthrough technologies cancer suppression. Polysaccharide-based drug delivery systems (DDSs) most reliable carriers therapy. Polysaccharides, kind practical biomaterials, divided into types, including chitosan, alginates, dextran, hyaluronic acid, cyclodextrin, pectin, etc. Polysaccharides extracted from different natural resources (like herbal, marine, microorganisms, etc.). The potential features polysaccharides made them candidates therapeutics to sites; simple purification, ease modification functionalization, hydrophilicity, serum stability, appropriate loading capacity, biocompatibility, bioavailability, biodegradability stimuli-responsive sustained release manner considerable aspects these biopolymers. This review highlights applications polysaccharides-based DDSs pharmaceutical science

Language: Английский

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Recent advances in chitosan-based smart hydrogel for drug delivery systems

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 280, P. 135803 - 135803

Published: Oct. 17, 2024

Language: Английский

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Recent advances on chitosan/hyaluronic acid-based stimuli-responsive hydrogels and composites for cancer treatment: A comprehensive review

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 135893 - 135893

Published: Sept. 1, 2024

Language: Английский

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Encapsulation of β-carotene in Pickering emulsions stabilized by self-aggregated chitosan nanoparticles: Factors affecting β-carotene stability

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 277, P. 133696 - 133696

Published: July 31, 2024

Language: Английский

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Interpenetrating Polymer Network of Hydroxyethyl Methacrylate and Chitosan as Cryogels for Tissue Engineering Applications

Polymers for Advanced Technologies, Journal Year: 2025, Volume and Issue: 36(1)

Published: Jan. 1, 2025

ABSTRACT Tissue engineering is a vast expanding field with applications in areas such as tissue/organ transplantation, drug delivery, vitro models, and so on. Biomaterials form an essential component tissue by acting template for cellular activity, therefore, novel tissue‐engineered biomaterials innovative properties are high demand. Hence, this work proposes interpenetrating polymer network cryogel of chitosan hydroxyethyl methacrylate (HEMA) biomaterial uniform cell seeding throughout the matrix. The physical analysis cryogels demonstrated highly macroporous structure exhibiting pore size distribution overall porosity through emission‐scanning electron microscopy (FE‐SEM) sizes lying range 50–200 μm 150–400 horizontal transverse plane, respectively. were also found to be degradable average percent degradation 17.28 ± 1.47% 4 weeks, their mechanical revealed compressive strength 0.05 MPa elastic modulus 3 MPa. Further, biological characterization direct contact test depicted excellent biocompatibility L929 mouse fibroblast MC3T3‐E1 preosteoblasts negligible presence dead cells around cryogel. Uniform increasing proliferation trend was observed on these live‐dead staining MTT assay at day 1, 3, 7‐time point. Cell adherence studies via FE‐SEM similar along flattened morphology extracellular matrix production. Therefore, based promising physico‐chemical properties, HEMA‐Chitosan exhibit strong potential application engineered biomaterials.

Language: Английский

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Dual targeting of breast cancer by chitosan/poly lactic-co-glycolic acid nanodelivery systems: Surface activation with folic acid/aptamers, and co-encapsulated with Sorafenib and quercetin

Carbohydrate Polymer Technologies and Applications, Journal Year: 2025, Volume and Issue: unknown, P. 100695 - 100695

Published: Feb. 1, 2025

Language: Английский

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