MALAT1: A key regulator in lung cancer pathogenesis and therapeutic targeting

Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 253, P. 154991 - 154991

Published: Nov. 30, 2023

Language: Английский

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Unlocking the secrets: Volatile Organic Compounds (VOCs) and their devastating effects on lung cancer

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 255, P. 155157 - 155157

Published: Jan. 26, 2024

Language: Английский

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Exploring ncRNA-mediated regulation of EGFR signalling in glioblastoma: From mechanisms to therapeutics

Life Sciences, Journal Year: 2024, Volume and Issue: 345, P. 122613 - 122613

Published: April 4, 2024

Language: Английский

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The impact of formaldehyde exposure on lung inflammatory disorders: Insights into asthma, bronchitis, and pulmonary fibrosis

Chemico-Biological Interactions, Journal Year: 2024, Volume and Issue: 394, P. 111002 - 111002

Published: April 9, 2024

Lung inflammatory disorders are a major global health burden, impacting millions of people and raising rates morbidity death across many demographic groups. An industrial chemical common environmental contaminant, formaldehyde (FA) presents serious concerns to the respiratory system, including onset aggravation lung disorders. Epidemiological studies have shown significant associations between FA exposure levels incidence severity several diseases. causes inflammation in tract via immunological activation, oxidative stress, airway remodelling, aggravating pre-existing pulmonary compromising function. Additionally, functions as sensitizer, causing allergic responses hypersensitivity pneumonitis sensitive people. Understanding complicated processes behind formaldehyde-induced is critical for directing targeted strategies aimed at minimizing exposures alleviating burden formaldehyde-related illnesses on health. This abstract explores intricate relationship diseases, asthma, bronchitis, inflammation, injury fibrosis.

Language: Английский

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CircRNAs: Pivotal modulators of TGF-β signalling in cancer pathogenesis

Non-coding RNA Research, Journal Year: 2024, Volume and Issue: 9(2), P. 277 - 287

Published: Jan. 26, 2024

The intricate molecular landscape of cancer pathogenesis continues to captivate researchers worldwide, with Circular RNAs (circRNAs) emerging as pivotal players in the dynamic regulation biological functions. study investigates elusive link between circRNAs and Transforming Growth Factor-β (TGF-β) signalling pathway, exploring their collective influence on progression metastasis. Our comprehensive investigation begins by profiling circRNA expression patterns diverse types, revealing a repertoire intricately linked TGF-β pathway. Through integrated bioinformatics analyses functional experiments, we elucidate specific circRNA-mRNA interactions that modulate signalling, unveiling regulatory controls governing this crucial Furthermore, provide compelling evidence impact circRNA-mediated modulation key cellular processes, including epithelial-mesenchymal transition (EMT), migration, cell proliferation. In addition mechanistic roles, have shown promise diagnostic prognostic biomarkers, well potential targets for therapy. Their ability critical pathways, such axis, underscores significance biology clinical applications. interplay is dissected, uncovering novel circuits contribute complexity biology. This review unravels previously unexplored dimension carcinogenesis, emphasizing role shaping landscape.

Language: Английский

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Hypoxia-inducible factor and cellular senescence in pulmonary aging and disease

Biogerontology, Journal Year: 2025, Volume and Issue: 26(2)

Published: Feb. 26, 2025

Abstract Cellular senescence and hypoxia-inducible factor (HIF) signaling are crucial in pulmonary aging age-related lung diseases such as chronic obstructive disease idiopathic fibrosis cancer. HIF plays a pivotal role cellular adaptation to hypoxia, regulating processes like angiogenesis, metabolism, inflammation. Meanwhile, leads irreversible cell cycle arrest, triggering the senescence-associated secretory phenotype which contributes inflammation, tissue remodeling, fibrosis. Dysregulation of these pathways accelerates progression by promoting oxidative stress, mitochondrial dysfunction, epigenetic alterations. Recent studies indicate that interact at multiple levels, where can both induce suppress senescence, depending on conditions. While transient activation supports repair stress resistance, dysregulation exacerbates pathologies. Furthermore, emerging evidence suggests targeting could offer new therapeutic strategies mitigate diseases. This review explores intricate crosstalk between mechanisms, shedding light how their interplay influences progression. Additionally, we discuss potential interventions, including senolytic therapies modulators, enhance health longevity.

Language: Английский

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From carcinogenesis to therapeutic avenues: lncRNAs and mTOR crosstalk in lung cancer

Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 253, P. 155015 - 155015

Published: Dec. 6, 2023

Language: Английский

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Targeting MAPK signaling: A promising approach for treating inflammatory lung disease

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 254, P. 155122 - 155122

Published: Jan. 11, 2024

Language: Английский

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Exosomal ncRNAs in liquid biopsies for lung cancer

Clinica Chimica Acta, Journal Year: 2024, Volume and Issue: 565, P. 119983 - 119983

Published: Oct. 3, 2024

Language: Английский

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ncRNAs and their impact on dopaminergic neurons: Autophagy pathways in Parkinson's disease

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 98, P. 102327 - 102327

Published: May 10, 2024

Language: Английский

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