Differential gene expression in PBMCs: Insights into the mechanism how pulmonary tuberculosis increases lung cancer risk DOI Creative Commons
Jie Wu, Yang Chen, Xiaoqi Yang

et al.

Gene, Journal Year: 2024, Volume and Issue: 940, P. 149199 - 149199

Published: Dec. 27, 2024

Pre-existing of pulmonary tuberculosis (PTB) poses increased lung cancer risk, yet the molecular mechanisms remain inadequately understood. This study sought to elucidate potential by performing comprehensive analyses differentially expressed genes (DEGs) in peripheral blood mononuclear cells (PBMCs) from patients with PTB, adenocarcinoma (LUAD), and squamous cell carcinoma (LUSC). Microarray assays were employed analyze DEGs PBMCs these patients. The revealed that, compared healthy controls, number LncRNA LUAD, LUSC 801, 8,541, 7,796, respectively. Similarly, mRNA 629, 4,865, 4,438, These transcripts represent significant resources for identifying diagnostic differential biomarkers PTB. Pathways enriched dysregulated mRNAs identified through GO KEGG pathway analyses. results indicated that 9 pathways including NOD-like receptor signaling pathway, cancer, MAPK co-enriched across groups, providing insights into which PTB may increase risk development progression.

Language: Английский

Asparagus officinalis polysaccharide-loaded liposomal gels alleviate skin inflammation via inhibiting the NF-κB/MAPK pathways DOI

Rongrui Zhang,

Yu Xiong,

Yujin Ma

et al.

Journal of Functional Foods, Journal Year: 2025, Volume and Issue: 125, P. 106679 - 106679

Published: Jan. 18, 2025

Language: Английский

Citations

1
An updated review of the pharmacological effects and potential mechanisms of hederagenin and its derivatives DOI Creative Commons

Huize Zhang,

Li Yong, Yi Liu

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: June 19, 2024

Hederagenin (HG) is a natural pentacyclic triterpenoid that can be isolated from various medicinal herbs. By modifying the structure of HG, multiple derivatives with superior biological activities and safety profiles have been designed synthesized. Accumulating evidence has demonstrated HG its display pharmacological against cancers, inflammatory diseases, infectious metabolic fibrotic cerebrovascular neurodegenerative depression. Previous studies confirmed combat cancer by exerting cytotoxicity, inhibiting proliferation, inducing apoptosis, modulating autophagy, reversing chemotherapy resistance in cells, action targets involved mainly include STAT3, Aurora B, KIF7, PI3K/AKT, NF-κB, Nrf2/ARE, Drp1, P-gp. In addition, antagonize inflammation through production release pro-inflammatory cytokines mediators regulating inflammation-related pathways targets, such as MAPK, JAK2/STAT3, Keap1-Nrf2/HO-1, LncRNA A33/Axin2/β-catenin. Moreover, anti-pathogen, anti-metabolic disorder, anti-fibrosis, neuroprotection, anti-depression mechanisms partially elucidated. The diverse properties hold significant implications for future research development new drugs derived which lead to improved effectiveness profiles.

Language: Английский

Citations

4
Ficus pumila fruit polysaccharide alleviates OVA-induced allergic asthma mice through the MAPK/NF-κB signaling pathway DOI
Xiaomei Ye,

Shiru Mo,

Chengyuan Wang

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 105827 - 105827

Published: Jan. 1, 2025

Language: Английский

Citations

0
Characterizing COPD phenotypes with a targeted signaling lipids metabolomics approach DOI Creative Commons
Lu Zhang,

Jean Marie Wernet,

Andreas Rothgangel

et al.

Life Sciences, Journal Year: 2025, Volume and Issue: 364, P. 123438 - 123438

Published: Jan. 31, 2025

Language: Английский

Citations

0
Unveiling the impact of CD133 on cell cycle regulation in radio- and chemo-resistance of cancer stem cells DOI Creative Commons

Luyao Wu,

Takanori Katsube, Xiaofei Li

et al.

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 6, 2025

The adaptation of malignancy to therapy presents a significant challenge in cancer treatment. cell cycle plays crucial role regulating the evolution radio- and chemo-resistance tumor cells. Cancer stem cells (CSCs) are primary source resistance, with CD133 being one most recognized valuable surface markers CSCs. Evidence increasingly suggests that is associated resistance. current understanding molecular biological function limited, leading ongoing debates about its biology. In this review, we explore recent research emerging trends related through extensive literature content analysis. It was summarized new insights into relationships signaling pathways resistant aim review provide foundational how these their interactions impact prognosis inform treatment strategies.

Language: Английский

Citations

0
Rv2741 Promotes Mycobacterium Survival by Modulating Macrophage Function via the IL-1α-MAPK Axis DOI

Xintong He,

Yonglin He, Xichuan Deng

et al.

ACS Infectious Diseases, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

One of the primary healthcare problems in world today is tuberculosis (TB), a chronic infectious illness brought on by Mycobacterium (M. tuberculosis). A distinct family PE_PGRS proteins, encoded M. genome, has attracted more attention because their involvement immune evasion and bacterial pathogenicity. Nevertheless, specific functions mechanisms action for majority proteins remain largely unexplored. This study focuses Rv2741 (PE_PGRS47) gene, which exclusively present pathogenic mycobacteria. To examine function host–pathogen interactions, we created recombinant strains smegmatis smegmatis) that expressed gene. IL-1α was found to be key mediator host response modulation Rv2741. downregulates secretion inhibits MAPK signaling pathway, particularly p38 ERK1/2 pathways, thereby cooperatively inhibiting macrophage autophagy apoptosis. Meanwhile, decrease directly leads changes cytokine pattern reduction nitric oxide (NO) production. multifaceted regulatory mechanism ultimately favors survival macrophages. research significantly expands our understanding function, revealing its crucial role as multifunctional virulence factor tuberculosis.

Language: Английский

Citations

0
Prunin: An Emerging Anticancer Flavonoid DOI Open Access
Juie Nahushkumar Rana, Sohail Mumtaz

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2678 - 2678

Published: March 16, 2025

Despite the substantial advances in cancer therapies, developing safe and effective treatment methodologies is critical. Natural (plant-derived compounds), such as flavonoids, might be crucial a methodology without toxicity toward healthy tissues. Prunin flavonoid with potential to used biomedical applications. has yet undergo thorough scientific research, its precise molecular mechanisms of action remain largely unexplored. This review summarizes therapeutic prunin for first time, focusing on underlying an anticancer compound. gained significant attention due antioxidant, anti-inflammatory, effects. aims unlock how functions at level exert effects, primarily modulating key cellular pathways. Furthermore, we have discussed prunin’s adjunctive therapy conventional treatments, highlighting ability strengthen responses while decreasing drug resistance. Moreover, discussion probes into innovative delivery methods, particularly nanoformulations, that address bioavailability, solubility, stability limitations optimize application. By providing comprehensive analysis properties, this stimulate further exploration using agent, thereby progressing development targeted, selective, safe, methods.

Language: Английский

Citations

0
Modulation of renal fibrosis-related signaling pathways by traditional Chinese medicine: molecular mechanisms and experimental evidence DOI
Yufei Yang, Longshan Zhao, Fengli Gao

et al.

International Urology and Nephrology, Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

Language: Английский

Citations

0
Chlorogenic acid attenuates idiopathic pulmonary fibrosis: An integrated analysis of network pharmacology, molecular docking, and experimental validation DOI
Juan Manuel Velázquez-Enríquez, Jovito Cesar Santos-Álvarez,

Alma Aurora Ramírez-Hernández

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 734, P. 150672 - 150672

Published: Sept. 7, 2024

Language: Английский

Citations

3
Oxidative Stress Triggers Itch-mediated TXNIP Degradation and NF-κB Activation Promoting Chronic Obstructive Pulmonary Disease DOI
Pei‐Yun Lin, Kang‐Yun Lee, Shu‐Chuan Ho

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: May 7, 2025

Abstract Background Chronic inflammatory lung diseases, including chronic obstructive pulmonary disease (COPD), are characterized by structural changes, narrowing of the small airways, and destruction parenchyma caused prolonged inflammation. Sustained inflammation mediated macrophages is considered to play a critical role in COPD pathogenesis, while inductive mechanisms persistent remain unclear. Methods In vitro, RAW264.7 cells were treated with cigarette smoke extract (CSE), hydrogen peroxide, 12-O-tetradecanoylphorbol-13-acetate. Loss-of-function assays performed using MAPK inhibitors Itch-specific knockdown. In vivo, tissues from mice exposed whole-body for 12 weeks, as well clinical samples healthy non-smokers, smoker, patients, analyzed. Results We revealed that thioredoxin-interacting protein (TXNIP) participates smoke-incited NF-κB activation potentially conducted CSE markedly inhibits TXNIP expression through MAPKs-dependent regulation, accompanied induction iNOS/NO COX-2. The decrease was also detected obtained smoking mice, higher occurred simultaneously. Additionally, smoke-associated oxidative stress initiated proteasomal degradation followed MAPKs-regulated concurrently. E3 ligase Itch elevated mouse lungs peroxide-stimulated cells, whereas specific silencing significantly attenuated activation. Moreover, distinctly suppressed tissues, bronchoalveolar lavage fluid peripheral blood mononuclear patients COPD. Conclusion Accordingly, smoke-induced causes Itch-mediated degradation, leading enabling pathogenesis.

Language: Английский

Citations

0