Metal-organic frameworks: synthesis, properties, wound dressing, challenges and scopes in advanced wound dressing

Biomedical Materials, Journal Year: 2024, Volume and Issue: 19(5), P. 052001 - 052001

Published: July 8, 2024

Abstract Wound healing is a critical but complex biological process of skin tissue repair and regeneration resulting from various systems working together at the cellular molecular levels. Quick wound problems associated with traditional techniques are being overcome multifunctional materials. Over time, this research area has drawn significant attention. Metal-organic frameworks (MOFs), owning to their peculiar physicochemical characteristics, now considered promising class well-suited porous materials for in addition other applications. This detailed literature review provides an overview latest developments MOFs We have discussed synthesis, essential biomedical properties, wound-healing mechanism, MOF-based dressing materials, The possible major challenges limitations been discussed, along conclusions future perspectives. addresses MOFs-based several angles covers most current subject. readers may discover how advanced discipline by producing more inventive, useful, successful dressings. It influences development generations biomaterials wounds.

Language: Английский

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Stimulus-responsive polysaccharide-based hydrogels: From design to biomedical applications

Precision medicine and engineering., Journal Year: 2024, Volume and Issue: 1(1), P. 100001 - 100001

Published: July 28, 2024

Stimulus-responsive hydrogels can undergo controllable shape deformation and exhibit sol-gel transition behavior under stimulus signals such as pH, reactive oxygen species (ROS), heat, light. Polysaccharides have become ideal candidates for constructing stimulus-responsive due to their biocompatibility biodegradability. The diversity of molecular weights functional groups polysaccharides allows them self-assemble or cooperate with other materials obtain through physical chemical crosslinking. Bioactive ingredients nanomaterials be conveniently encapsulated in the hydrogel matrix meet various requirements. polysaccharide-based are widely used biomedical field, especially fields drug delivery, tissue engineering, biosensors, imaging. In this review, design strategies recent research advances stimuli-responsive summarized. Future challenges also presented, review will guide study polysaccharide hydrogels.

Language: Английский

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Nano-encapsulation and characterizations of glimepiride drug with chitosan nanoparticles and its in vitro drug release kinetics and antidiabetic activity

Materials Today Communications, Journal Year: 2024, Volume and Issue: 39, P. 109333 - 109333

Published: May 23, 2024

Language: Английский

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The role of multivalent cations in determining the cross-linking affinity of alginate hydrogels: A combined experimental and modeling study

Chemical Engineering Journal Advances, Journal Year: 2024, Volume and Issue: 20, P. 100678 - 100678

Published: Nov. 1, 2024

Language: Английский

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Clinical Applicable Carboxymethyl Chitosan with Gel-Forming and Stabilizing Properties Based on Terminal Sterilization Methods of Electron Beam Irradiation

ACS Omega, Journal Year: 2024, Volume and Issue: 9(16), P. 18599 - 18607

Published: April 9, 2024

Carboxymethyl chitosan (CMC)-based hydrogels have great potential for clinical applications, but a critical sterilization process must be addressed to bring them market. Compared ethylene oxide or heat sterilization, irradiation avoids alkylation and damage, while available studies on γ-irradiated other polysaccharides show that solution are susceptible degradation cross-linking. Aiming at the challenges brought by γ-irradiation of polysaccharide aqueous solution, this paper innovatively proposes lyophilized CMC using electron beam (EB) irradiation, which not only generation free radicals in irradiated water leading cross-linking also retains properties terms gel formation, stabilization, application. We used FTIR, TG, GPC, microbial load tests demonstrate did significant changes structure molecular weight after EB complied with requirements still had stability, thus proving could met Therefore, work is expected further advance injectable toward applications provide new direction processes hydrogels.

Language: Английский

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Fabrication and characterization of a new eco-friendly sulfonamide-chitosan derivative with enhanced antimicrobial and selective cytotoxicity properties

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: May 3, 2024

Abstract Chitosan (CH) exhibits low antimicrobial activity. This study addresses this issue by modifying the chitosan with a sulfonamide derivative, 3-(4-(N,N-dimethylsulfonyl)phenyl)acrylic acid. The structure of sulfonamide-chitosan derivative (DMS-CH) was confirmed using Fourier transform infrared spectroscopy and Nuclear magnetic resonance. results scanning electron microscopy, thermal gravimetric analysis, X-ray diffraction indicated that morphology changed to porous nature, stability decreased, crystallinity increased in DMS-CH compared chitosan, respectively. degree substitution calculated from elemental analysis data found be moderate (42%). modified exhibited enhanced properties at concentrations, minimum inhibitory concentration (MIC) 50 µg/mL observed for B. subtilis P. aeruginosa , value 25 S. aureus E. coli C. albicans . In case native MIC values doubled or more, recorded 100 μg/mL Furthermore, toxicological examinations conducted on MCF-7 (breast adenocarcinoma) cell lines demonstrated greater toxicity (IC50 = 225.47 μg/mL) than pure CH, while still maintaining significant safety limits against normal lung fibroblasts (WI-38). Collectively, these suggest potential use newly biomedical applications.

Language: Английский

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Recycling kaolin from paper waste and assessment of its application for paper coating

Materials Today Communications, Journal Year: 2024, Volume and Issue: 39, P. 109142 - 109142

Published: May 7, 2024

Language: Английский

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Lysine-Triggered Polymeric Hydrogels with Self-Adhesion, Stretchability, and Supportive Properties

Polymers, Journal Year: 2024, Volume and Issue: 16(10), P. 1388 - 1388

Published: May 13, 2024

Hydrogels, recognized for their flexibility and diverse characteristics, are extensively used in medical fields such as wearable sensors soft robotics. However, many hydrogel derived from biomaterials lack mechanical strength fatigue resistance, emphasizing the necessity enhanced formulations. In this work, we utilized acrylamide polyacrylamide primary polymer network, incorporated chemically modified poly(ethylene glycol) (DF-PEG) a physical crosslinker, introduced varying amounts of methacrylated lysine (LysMA) to prepare series hydrogels. This formulation was labeled poly(acrylamide)-DF-PEG-LysMA, abbreviated pADLx, with x denoting weight/volume percentage LysMA. We observed that when contained 2.5% w/v LysMA (pADL2.5), compared hydrogels without (pADL0), its stress increased by 642 ± 76%, strain 1790 95%, toughness 2037 320%. Our speculation regarding performance pADL2.5 revolves around synergistic effects arising co-polymerization formation multiple intermolecular hydrogen bonds within network structures. Moreover, acid, amine, amide groups present molecules have proven be instrumental contributors self-adhesion capability hydrogel. The validation hydrogel’s exceptional properties through rigorous tensile tests further underscores suitability use sensors. outstanding stretchability, adhesive strength, resistance demonstrated affirm potential key component development robust reliable fulfill practical requirements.

Language: Английский

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A novel NO-releasing composite hydrogel for infected wound healing

Materials Today Communications, Journal Year: 2024, Volume and Issue: 39, P. 109321 - 109321

Published: May 21, 2024

Language: Английский

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Composite hydrogels fabricated from CMC-PVA-GG incorporated with ZiF-8 for wound healing applications

Journal of Biomaterials Science Polymer Edition, Journal Year: 2024, Volume and Issue: 35(17), P. 2640 - 2659

Published: Aug. 7, 2024

The skin is at risk for injury to external factors since it serves as the body's first line of defense against environment. Hydrogels have drawn much interest due their intrinsic extracellular matrix (ECM) properties and biomimetic, structural, durable mechanical characteristics. enormous potential use in wound healing ability deliver bioactive substances easily. In this study, composite hydrogels were developed by blending guar gum (GG), polyvinyl alcohol (PVA), carboxymethyl cellulose (CMC) with crosslinker TEOS treatment. surface morphology, roughness, stability features characterized several techniques, such FTIR, SEM-EDX, AFM, DSC. increasing ZiF-8 causes more decreased swelling different media (Aqueous > PBS NaCl). amount less hydrophilic behavior biodegradation gel fraction. cytocompatibility Zinc imidazolate framework-8 (ZiF-8) based composites was evaluated fibroblast cell lines viability, proliferation, morphology. caused viability proliferation proper Hence, results show that synthesized may be a candidate numerous repair applications.

Language: Английский

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