A Self-Gelling Powder Based on Polyacrylic Acid/Polyethyleneimine/Polyethylene Glycol for High-Performance Hemostasis and Antibacterial Activity DOI Open Access
Jia Li, Shu Li,

Aozhen Zhong

et al.

Polymers, Journal Year: 2024, Volume and Issue: 16(24), P. 3516 - 3516

Published: Dec. 18, 2024

Powder-based hemostatic materials have offered unprecedented opportunities for the effective sealing and repair of irregularly shaped wounds high-pressure, noncompressible arterial bleeding caused by surgeries, traffic accidents, wartime injuries. However, inadequate adhesion to poor hemostasis in biological tissues remains challenging. Herein, we report a self-gelling powder based on polyacrylic acid/polyethyleneimine/polyethylene glycol (named PPG) rapid antibacterial ability. When deposited wounds, PPG can absorb interfacial liquid rapidly swell into physically cross-linked hydrogel situ within 2 s form pressure-resistant physical barrier. Furthermore, vivo vitro results indicate that, as an sealant, possesses ease use, excellent hemocompatibility, strong abilities, superior blood clotting abilities. The capability is demonstrated variety injury models rats rabbits. All these factors show with its wound treatment profound biomaterial surgical applications.

Language: Английский

In Situ-Forming, Adhesive, and Antioxidant Chitosan Hydrogels for Accelerated Wound Healing DOI
Ying Luo, Yiping Zhao, Li Chen

et al.

Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Antioxidant hydrogels that can provide a moist environment and scavenge reactive oxygen species have emerged as highly potential wound dressing materials. In situ-forming good tissue adhesiveness will make them more desirable, they fill the irregular defect, stick to wound, offer intimate contact with wound. Herein, hydrogel combining in situ-forming, adhesiveness, excellent antioxidant capabilities was developed by simply conjugating dopamine onto carboxymethyl chitosan. The introduction of allows situ gelation polymer under mild conditions using an HRP-catalyzed cross-linking reaction. also endows suitable tissue-adhesion properties. Excellent properties were imparted result dopamine. Thanks favorable provided effectively mitigated oxidative stress at sites, accelerated healing reduced scar formation observed rat full-thickness skin model.

Language: Английский

Citations

0
Development of hyaluronic acid-based hydrogels for chronic diabetic wound healing: A review DOI
Wenhao Zhang, Yang Liu,

Ling Zhang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142273 - 142273

Published: March 1, 2025

Language: Английский

Citations

0
A Fungistatic Strategy Using a Shear-Thinning pH-Responsive CMCS-OHA-Lp/Lr Hydrogel for Vulvovaginal Candidiasis DOI Creative Commons
Yuanyuan Zhao,

Xiu De Yang,

Jiale Han

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(4), P. 527 - 527

Published: April 17, 2025

Background: Vulvar vaginal candidiasis (VVC) is a type of vaginitis resulting from Candida infection the mucosa. Traditional treatments using antibiotics often lead to resistance and disrupt microenvironment, causing ongoing problems for patients. In response these challenges, this study introduces multifunctional intelligent responsive probiotic hydrogel designed modulate microecological environment combat albicans infection. Methods: The innovative CMCS-OHA-Lp/Lr was formulated oxidized hyaluronic acid (OHA) carboxymethyl chitosan (CMCS) as carriers, incorporating Lactobacillus plantarum (Lp) rhamnosus (Lr) active components. Comprehensive characterization revealed its chemical structure, rheological properties, rapid self-healing gel degradation, release lactobacilli in vitro. Results: findings demonstrated that hydrogel’s cross-linking conferred significant physical properties. addition, vitro showed cumulative rates Lp Lr medium with pH 5.5 were 83.50 ± 2.70% 73.31 2.22%, which proved pH-responsive characteristics probiotics acidic environments. Furthermore, storage activity indicated survival CMCS-OHA-Lp CMCS-OHA-Lr hydrogels 86.90 0.20% 85.50 0.56%, respectively, proving encapsulation within significantly enhanced stability probiotics. vivo studies further confirmed alleviated vulval edema symptoms reduced C. colonies vagina, thereby mitigating inflammation. Conclusions: conclusion, pH-responsive, self-healing, shear-thinning offers promising approach clinical treatment VVC serves an effective delivery vehicle.

Language: Английский

Citations

0
Enzyme-mediated hydrogelation for biomedical applications: A review DOI
Yue Qi, Fangfang Wang, Junliang Liu

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143379 - 143379

Published: April 1, 2025

Language: Английский

Citations

0
Functional potential of chitosan-metal nanostructures: Recent developments and applications DOI
Shamsa Kanwal, Sadia Bibi,

Rabia Haleem

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 136715 - 136715

Published: Oct. 23, 2024

Language: Английский

Citations

3
Biodegradable, biocompatible, and self-healing, injectable hydrogel based on oxidized Azadirachta indica gum and carboxymethyl chitosan through dynamic imine-linkage for biomedical application DOI
Jitendra Kumar, Roli Purwar

Iranian Polymer Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 13, 2024

Language: Английский

Citations

2
The Characteristics Analysis of Hyaluronic Acid Modified By Cold Atmospheric Plasma and Its Performance in Hydrogel Preparation DOI

Tianao Xu,

Xiaolong Wang, Lian Li

et al.

Plasma Processes and Polymers, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 7, 2024

ABSTRACT Hyaluronic acid (HA) is extensively utilized in biomedical applications, and its functionality can be enhanced by introducing aldehyde groups (─CHO) through oxidation. In this study, cold atmospheric plasma (CAP) was used to treat aqueous HA solutions, resulting the formation of plasma‐modified (PMHA) containing ─CHO groups. The free radicals generated from interactions between water molecules CAP particles reacted with HA, leading oxidation hydroxyl into cleavage glycosidic bonds, causing molecular depolymerization. PMHA then synthesize hydrogels combination carboxymethyl chitosan ɛ‐polylysine. This study presents an effective approach for generating functionalities offers insights interaction polysaccharides.

Language: Английский

Citations

2
Polysaccharide-based hydrogels for atopic dermatitis management: A review DOI Creative Commons
Harinash Rao, Joash Ban Lee Tan

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 349, P. 122966 - 122966

Published: Nov. 13, 2024

Atopic dermatitis (AD) is the most common form of eczema and burdensome skin disease globally, affecting nearly 223 million. A major AD predisposition genetic susceptibility, barrier integrity cell-mediated immunity. Manifesting as red, dry, itchy skin, basic treatment involves hydration with emollients. Despite their effectiveness, poor patient compliance remains a drawback. In severe cases, medicated emollients are used, but carry risks, including thinning, immunosuppression. Hence, hydrogels have emerged promising alternative for management based on ability to improve hydration, attributed hydrophilicity high water retention capacity. Moreover, researchers loaded various compounds management; they also hold potential reduce systemic side effects commercial drugs by enhancing dermal retention. Hydrogels address challenges non-greasy texture reduced application frequency. Their appeal stems from versatility, can be fabricated varying polymers. Due abundance, this review focuses polysaccharides alginate, cellulose, chitosan, hyaluronic acid, which preferred fabricating natural modified AD. It briefly explores hydrogel methods key models.

Language: Английский

Citations

2
Recent advances in bioactive wound dressings DOI Open Access
Md. Golam Nur, Mustafijur Rahman, Tanvir Mahady Dip

et al.

Wound Repair and Regeneration, Journal Year: 2024, Volume and Issue: 33(1)

Published: Nov. 14, 2024

Abstract Traditional wound dressings, despite their widespread use, face limitations, such as poor infection control and insufficient healing promotion. To address these challenges, bioactive materials have emerged a promising solution in care. This comprehensive review explores the latest developments technologies, starting with an overview of importance effective management, emphasising need for advanced dressings. The further various materials, defining characteristics. It covers wide range natural synthetic biopolymers used to develop Next, paper discusses incorporation agents into including antimicrobial anti‐inflammatory agents, alongside regenerative components like growth factors, platelet‐rich plasma, fibrin stem cells. also fabrication techniques highlighting electrospinning, which facilitated production nanofibre‐based dressings controlled porosity, sol–gel method developing glass‐based 3D bioprinting customised, patient‐specific concludes by addressing challenges future perspectives dressing development. includes regulatory considerations, clinical efficacy, patient care protocol integration progress monitoring. Furthermore, considers emerging trends smart sensors personalised medicine approaches, offering insights direction research.

Language: Английский

Citations

2
Advanced hydrogel material for colorectal cancer treatment DOI Creative Commons
Yu Guo,

Min Wang,

Yu‐Zhong Zhang

et al.

Drug Delivery, Journal Year: 2024, Volume and Issue: 32(1)

Published: Dec. 31, 2024

Colorectal cancer is one of the most common cancers worldwide, and its incidence rates are increasing every year. Treatments for CRC include surgical resection, chemotherapy, radiotherapy, targeted therapy, immunotherapy. Although various agents have been used in treatment malignant tumors, they not as effective expected. This primarily owing to lack selectivity, poor solubility, severe side effects agents. It necessary develop more efficient drug delivery systems precise targeting tumor site therapeutic meet clinical needs. A hydrogel a three-dimensional network material composed crosslinked chains hydrophilic or hydrophobic groups polymer backbone. Hydrogels possess useful properties including high water content, adjustable physical characteristics, elasticity, flexibility, reversible swelling, multifunctionality. These render them ideal biomaterials with broad range applications biomedicine bioengineering. In this review, we introduce pathophysiology current advances summarize hydrogels different materials well smart response carriers treatment. We also analyze unique advantages challenges using therapy.

Language: Английский

Citations

2