Recent progress of exosomal lncRNA/circRNA–miRNA–mRNA axis in lung cancer: implication for clinical application DOI Creative Commons
Ren Wang, Yiwei Xu,

Liangjing Tong

et al.

Frontiers in Molecular Biosciences, Journal Year: 2024, Volume and Issue: 11

Published: July 3, 2024

Lung cancer is the leading cause of death among malignant tumors in world. High lung mortality rate due to most patients diagnosed at advanced stage. The Liquid biopsy have received recent interest for early diagnosis. One components liquid exosome. exosome cargos non-coding-RNAs, especially long non-coding RNAs (lncRNAs), circular (circRNAs), and microRNAs (miRNAs). derived exosomal play pivotal roles carcinogenesis, diagnosis, therapy, drug resistance prognosis cancer. Given ceRNA (competitive endogenous RNA) mechanism, lncRNA or circRNA can act as compete bind miRNAs alter expression targeted mRNA, contributing development progression current research progress non-coding-RNAs interplay ceRNAs mediated illustrated this article. Hence, we presented an experimentally validated RNAs-regulated target gene axis from already existed evidence Then LncRNA/circRNA-miRNA-mRNA may be a potential treatment has great diagnosis

Language: Английский

Recent advances to address challenges in extracellular vesicle-based applications for lung cancer DOI Creative Commons

Gaigai Huang,

Wenshu Zheng,

Yu Zhou

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(9), P. 3855 - 3875

Published: June 20, 2024

Lung cancer, highly prevalent and the leading cause of cancer-related death globally, persists as a significant challenge due to lack definitive tumor markers for early diagnosis personalized therapeutic interventions. Recently, extracellular vesicles (EVs), functioning natural carriers intercellular communication, have received increasing attention their ability traverse biological barriers deliver diverse cargoes, including cytosolic proteins, cell surface microRNA, lncRNA, circRNA, DNA, lipids. EVs are increasingly recognized valuable resource non-invasive liquid biopsy, well drug delivery platforms, anticancer vaccines precision medicine in lung cancer. Herein, given diagnostic potential tumor-associated we discuss this topic from translational standpoint. We delve into specific roles that play cancer carcinogenesis offer particular perspective on how advanced engineering technologies can overcome current challenges expedite and/or enhance translation laboratory research clinical settings.

Language: Английский

Citations

5
New insights on mesenchymal stem cells therapy from the perspective of the pathogenesis of nonalcoholic fatty liver disease DOI

Yanxuan Wen,

Jiaxing Li,

Omar Mukama

et al.

Digestive and Liver Disease, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
A Niche-Based Perspective to Stem and Cancer Stem Cells of the Lung DOI
Özge Boyacıoğlu,

Behnam Kalali,

Ege Tongün

et al.

Advances in experimental medicine and biology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Extracellular vesicles in non-small cell lung cancer stemness and clinical applications DOI Creative Commons
Prita Pandya, Dania S. Al-Qasrawi,

Skyeler Klinge

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: May 3, 2024

Non-small cell lung carcinoma (NSCLC) accounts for 85% of cancers, the leading cause cancer associated deaths in US and worldwide. Within NSCLC tumors, there is a subpopulation cells termed stem (CSCs) which exhibit stem-like properties that drive progression, metastasis, relapse, therapeutic resistance. Extracellular vesicles (EVs) are membrane-bound nanoparticles secreted by carry vital messages short- long-range intercellular communication. Numerous studies have implicated CSC-derived EVs factors with lethality. In this review, we discussed mechanisms EV-directed cross-talk between CSCs tumor microenvironment promote stemness, progression metastasis NSCLC. The mechanistic herein provided insights developing novel diagnostic prognostic biomarkers strategies to therapeutically target CSC niche.

Language: Английский

Citations

3
Competing endogenous RNAs regulatory crosstalk networks: The messages from the RNA world to signaling pathways directing cancer stem cell development DOI Creative Commons

Hamid Aria,

Mahdieh Azizi,

Shima Nazem

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(15), P. e35208 - e35208

Published: July 26, 2024

Cancer stem cells (CSCs) are one of the cell types that account for cancer heterogeneity. The arrest in G0 and generate non-CSC progeny through self-renewal pluripotency, resulting tumor recurrence, metastasis, resistance to chemotherapy. They can stimulate relapse re-grow a metastatic tumor. So, CSCs is promising target eradicating tumors, developing an anti-CSCs therapy has been considered. In recent years competing endogenous RNA (ceRNA) emerged as significant class post-transcriptional regulators affect gene expression via competition microRNA (miRNA) binding. Furthermore, aberrant ceRNA associated with progression. Recent findings show network cause progression effect on CSCs. To overcome therapeutic due CSCs, we need improve our current understanding mechanisms by which ceRNAs implicated CSC-related relapse. Thus, this review was designed discuss role CSCs' function. Targeting may open path new targets be used clinical research.

Language: Английский

Citations

2
Recent progress of exosomal lncRNA/circRNA–miRNA–mRNA axis in lung cancer: implication for clinical application DOI Creative Commons
Ren Wang, Yiwei Xu,

Liangjing Tong

et al.

Frontiers in Molecular Biosciences, Journal Year: 2024, Volume and Issue: 11

Published: July 3, 2024

Lung cancer is the leading cause of death among malignant tumors in world. High lung mortality rate due to most patients diagnosed at advanced stage. The Liquid biopsy have received recent interest for early diagnosis. One components liquid exosome. exosome cargos non-coding-RNAs, especially long non-coding RNAs (lncRNAs), circular (circRNAs), and microRNAs (miRNAs). derived exosomal play pivotal roles carcinogenesis, diagnosis, therapy, drug resistance prognosis cancer. Given ceRNA (competitive endogenous RNA) mechanism, lncRNA or circRNA can act as compete bind miRNAs alter expression targeted mRNA, contributing development progression current research progress non-coding-RNAs interplay ceRNAs mediated illustrated this article. Hence, we presented an experimentally validated RNAs-regulated target gene axis from already existed evidence Then LncRNA/circRNA-miRNA-mRNA may be a potential treatment has great diagnosis

Language: Английский

Citations

1