Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Oct. 25, 2024
The
great
potential
of
polysaccharides
in
immunological
regulation
has
recently
been
highlighted
pharmacological
and
clinical
studies.
Polysaccharides
can
trigger
immunostimulatory
responses
through
molecular
identification,
intra-
intercellular
communication
via
direct
or
indirect
interactions
with
the
immune
system.
Various
their
derivative
compounds
interacts
at
cellular
level
to
boost
system,
including
arabinogalactans,
fucoidans,
mannans,
xylans,
galactans,
hyaluronans,
fructans,
pectin
etc.
These
natural
are
derived
from
various
plants,
animals
microbes.
A
unique
structural
diversity
identified
polysaccharides,
while
monosaccharides
glucosidic
bonds
mainly
confer
diverse
biological
activities.
improve
antioxidant
capacity,
reduce
production
pro-inflammatory
mediators,
strengthen
intestinal
barrier,
influence
composition
microbial
populations
promote
synthesis
short-chain
fatty
acids.
also
known
excessive
inflammatory
responses.
It
is
crucial
develop
polysaccharide-based
immunomodulators
that
could
be
used
prevent
treat
certain
diseases.
This
review
highlights
features,
immunomodulatory
properties,
underlying
mechanisms
naturally
occurring
activities
related
effects
by
elucidating
a
complex
relationship
between
immunity.
In
addition,
future
these
molecules
as
components
transform
pharmaceutical
applications
will
highlighted.
Artificial Cells Nanomedicine and Biotechnology,
Journal Year:
2024,
Volume and Issue:
52(1), P. 564 - 586
Published: Dec. 5, 2024
Cancer
has
a
high
rate
of
incidence
and
mortality
throughout
the
world.
Although
several
conventional
approaches
have
been
developed
for
treatment
cancer,
such
as
surgery,
chemotherapy,
radiotherapy
thermal
therapy,
they
remarkable
disadvantages
which
result
in
inefficient
cancer.
For
example,
immunogenicity,
prolonged
treatment,
non-specificity,
metastasis
cost
are
considered
major
drawbacks
chemotherapy.
Therefore,
there
is
fundamental
requirement
development
breakthrough
technologies
cancer
suppression.
Polysaccharide-based
drug
delivery
systems
(DDSs)
most
reliable
carriers
therapy.
Polysaccharides,
kind
practical
biomaterials,
divided
into
types,
including
chitosan,
alginates,
dextran,
hyaluronic
acid,
cyclodextrin,
pectin,
etc.
Polysaccharides
extracted
from
different
natural
resources
(like
herbal,
marine,
microorganisms,
etc.).
The
potential
features
polysaccharides
made
them
candidates
therapeutics
to
sites;
simple
purification,
ease
modification
functionalization,
hydrophilicity,
serum
stability,
appropriate
loading
capacity,
biocompatibility,
bioavailability,
biodegradability
stimuli-responsive
sustained
release
manner
considerable
aspects
these
biopolymers.
This
review
highlights
applications
polysaccharides-based
DDSs
pharmaceutical
science
Foods,
Journal Year:
2025,
Volume and Issue:
14(6), P. 1031 - 1031
Published: March 18, 2025
Tricholoma
matsutake,
as
a
rare
wild
edible
mushroom,
is
popular
due
to
its
unique
flavor
and
taste,
well
high
nutritional
economic
value.
Investigating
the
relationship
between
complex
structure
in
vitro
immunological
activity
of
TMP-2a,
novel
polysaccharide
isolated
from
T.
was
aim
this
study.
The
results
showed
that
TMP-2a
consisted
six
monosaccharides,
fucose,
glucosamine
hydrochloride,
galactose,
glucose,
mannose,
glucuronic
acid,
with
molar
ratios
8.8:0.6:23.4:48.1:15.1:4.0
molecular
weight
27,749
Da.
Furthermore,
mainly
composed
→6)-β-Glcp-(1→
→3)-β-D-Glcp-(1→
forming
main
chain,
small
amount
→2,6)-α-D-Manp-(1→
→6)-α-D-Galp-(1→
structural
units
attached,
branched
chain
β-Glcp-(1→
or
α-L-Fucp-(1→
telosaccharide
attached
at
O-6
position
→3,6)-β-D-Glcp-(1→.
enhanced
proliferation
phagocytic
mouse
macrophage
RAW264.7,
secretion
NO
cytokines
(TNF-α,
IL-6,
IL-1β)
considerable
degree,
maybe
attributable
glucan
elevated
presence
(1→3)-β-D-Glcp
glycosidic
bonds.
This
study
establishes
basis
for
identification
comprehensive
investigation
functional
activities
matsutake
polysaccharides
while
also
offering
theoretical
framework
creation
matsutake-related
food
products.
Archiv der Pharmazie,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 9, 2024
Polysaccharides,
the
most
abundant
biopolymers
in
nature,
have
attracted
attention
of
researchers
and
clinicians
due
to
its
practicality
biomedical
pharmaceutical
sciences.
These
biomaterials
high
bioavailability
play
structural
functional
roles
living
organisms.
Polysaccharides
are
classified
into
several
groups
based
on
their
origin,
including
plant
polysaccharides
marine
(like
chitosan,
hyaluronic
acid,
dextran,
alginates,
etc.)
with
specific
applications.
possess
unique
physicochemical
(such
as
surface
groups,
solubility,
stability),
mechanical
strength
tensile),
antioxidant
activity,
biocompatibility,
biodegradability,
renewability,
non-immunogenicity)
characteristics
which
made
them
excellent
platforms
for
a
wide
variety
Ease
extraction
different
preparation
approaches
mentioned
other
potential
properties
that
further
improved
They
drug/bioactive
encapsulation
capacity
sustained/controlled
release
manner
vivo
microenvironments.
The
anti-inflammatory
immunomodulation,
stimuli-responsive
release,
passive
active
delivery
considered
features
these
indicated
practical
applications
sciences,
biosensors,
tissue
engineering,
implantation,
wound
healing,
vascular
grafting,
vaccines.
This
review
highlights
advances
polysaccharide-based
materials
