Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 203 - 252
Published: Nov. 29, 2024
Language: Английский
Small, Journal Year: 2024, Volume and Issue: 20(35)
Published: May 1, 2024
Abstract Cancer nanovaccines represent a promising frontier in cancer immunotherapy, utilizing nanotechnology to augment traditional vaccine efficacy. This review comprehensively examines the current state‐of‐the‐art nanovaccine development, elucidating innovative strategies and technologies employed their design. It explores both preclinical clinical advancements, emphasizing key studies demonstrating potential elicit robust anti‐tumor immune responses. The study encompasses various facets, including integrating biomaterial‐based nanocarriers for antigen delivery, adjuvant selection, impact of nanoscale properties on performance. Detailed insights into complex interplay between tumor microenvironment responses are provided, highlighting challenges opportunities optimizing therapeutic outcomes. Additionally, presents thorough analysis ongoing trials, presenting snapshot landscape. By curating latest scientific findings developments, this aims serve as comprehensive resource researchers clinicians engaged advancing immunotherapy. Integrating design holds immense promise revolutionizing treatment paradigms, provides timely update evolving landscape nanovaccines.
Language: Английский
Citations
24
Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 99, P. 102359 - 102359
Published: May 29, 2024
Language: Английский
Citations
8
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1345 - 1345
Published: Feb. 5, 2025
Exosomes are a subset of extracellular vesicles (EVs) secreted by nearly all cell types and have emerged as novel mechanism for intercellular communication within the central nervous system (CNS). These facilitate transport proteins, nucleic acids, lipids, metabolites between neurons glial cells, playing pivotal role in CNS development maintenance homeostasis. Current evidence indicates that exosomes from cells may function either inhibitors or enhancers onset progression neurological disorders. Furthermore, been found to disease-related molecules across blood–brain barrier, enabling their detection peripheral blood. This distinctive property positions promising diagnostic biomarkers conditions. Additionally, growing body research suggests derived mesenchymal stem exhibit reparative effects context review provides concise overview functions both physiological pathological states, with particular emphasis on emerging roles potential therapeutic agents treatment diseases.
Language: Английский
Citations
1
Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 7, 2025
Language: Английский
Citations
1
Drug Delivery and Translational Research, Journal Year: 2024, Volume and Issue: 15(4), P. 1121 - 1138
Published: Sept. 26, 2024
Language: Английский
Citations
5
Molecular Biomedicine, Journal Year: 2024, Volume and Issue: 5(1)
Published: Nov. 21, 2024
Abstract Extracellular vesicles (EVs) are cell-derived with a phospholipid bilayer measuring 50–150 nm in diameter demonstrated therapeutic potentials. Limitations such as the natural biodistribution (mainly concentrated liver and spleen) short plasma half-life of EVs present significant challenges to their clinical translation. In recent years, growing research indicated that engineered enhanced targeting lesion sites have markedly promoted efficacy. However, there is dearth systematic knowledge on advances engineering for targeted delivery. Herein, we provide an overview mechanisms, techniques, translations applications. Enrichment at may be achieved through recognition tissue markers, pathological changes, circumvention mononuclear phagocyte system (MPS). Alternatively, external stimuli, including magnetic fields ultrasound, also employed. EV techniques fulfill functions includes genetic engineering, membrane fusion, chemical modification physical modification. A comparative statistical analysis was conducted elucidate discrepancies between diverse size, morphology, stability, efficacy vitro vivo. Additionally, summary registered trials utilizing from 2010 2023 has been provided, full discussion perspectives. This review provides comprehensive mechanisms associated delivery applications advocate further explorations accelerate
Language: Английский
Citations
5
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 20, 2025
Background Intestinal ischemia-reperfusion injury (IIRI) is a severe clinical condition associated with high morbidity and mortality. Despite advances in understanding the pathophysiology of IIRI, effective diagnostic therapeutic strategies remain limited. Methods Using transcriptome sequencing mouse model we identified potential biomarkers that were significantly upregulated IIRI group compared to sham group. Based on these findings, developed evaluated strategy using milk-derived exosomes loaded siRNA targeting CCL7 (M-Exo/siCCL7). Results Focusing Ccl7 as hub gene, explored efficacy (M-Exo/siCCL7) model. M-Exo/siCCL7 treatment effectively attenuated intestinal inflammation injury, evidenced by reduced histological damage, decreased serum markers barrier dysfunction, systemic inflammation. Conclusion Our findings provide new insights into molecular mechanisms underlying identify biomarkers, highlight promise exosome-based delivery novel approach for IIRI.
Language: Английский
Citations
0
Life, Journal Year: 2025, Volume and Issue: 15(2), P. 294 - 294
Published: Feb. 13, 2025
Parkinson's disease (PD) is a progressive neurodegenerative disorder primarily characterized by the loss of dopaminergic neurons in substantia nigra. Mitochondrial dysfunction, oxidative stress, and neuroinflammation are recognized as critical pathological mechanisms driving neurodegeneration PD. Exosome (Exo)-based therapies, particularly those derived from human neural stem cells (hNSCs), offer promising neuroprotective effects due to their ability transfer bioactive molecules that modulate cellular processes. Resveratrol (RES), polyphenolic compound with potent antioxidant anti-inflammatory properties, has been shown enhance therapeutic potential cell (SC)-derived Exos. This study investigated RES-treated hNSCs-derived Exos (RES-hNSCs-Exos) on SH-SY5Y exposed 1-methyl-4-phenylpyridinium (MPP+), neurotoxin commonly used model Parkinsonian neurotoxicity. Treating MPP+ led significant reductions viability, mitochondrial increased activation inflammatory pathways. Treatment RES-hNSCs-Exos rescued MPP+-induced toxicity improving enhancing ATP production, increasing biogenesis, reducing reactive oxygen species (ROS) generation. The findings also demonstrated expression essential genes involved such PGC1α, NRF1, Tfam, indicating improved function presence RES-hNSCs-Exos. Further analysis revealed these protective were mediated activating AMP-activated protein kinase (AMPK) Nrf2 signaling pathways, which promoted health reduced stress. Moreover, treatment suppressed downregulating NLRP3 inflammasome secretion pro-inflammatory cytokines IL-1β IL-18. In conclusion, results suggest exhibit against neurotoxicity function, inhibiting neuroinflammation. These highlight hNSCs-Exos novel strategy for diseases like PD, RES valuable enhancer efficacy.
Language: Английский
Citations
0
Journal of Immunology Research, Journal Year: 2025, Volume and Issue: 2025(1)
Published: Jan. 1, 2025
Infections of central nervous system (ICNSs) are inflammatory diseases caused by infectious agents that can infiltrate the brain and spinal cord through various routes, including bloodstream, peripheral nerves, or cranial nerves. Exosomes found in plasma have capacity to cross blood-brain barrier (BBB). Exosome constituents, lipids, proteins, DNA, RNA, change significantly over time correlated with course disease. Circular RNA (circRNA) has become a potential biomarker for diseases, such as ICNSs. This study explores diagnostic circRNAs derived from brain-derived exosomes Our research shows patients CNS illnesses different patterns circRNA expression than those healthy controls. Plasma samples bacterial ICNSs show elevated levels hsa_circ__0020840 hsa_circ_0116108. In contrast, higher hsa_circ_0056947 hsa_circ_0021531 observed individuals viral compared subjects. These observations suggest their utility sensitive specific biomarkers these diseases. Moreover, be encapsulated within released into circulation offers noninvasive approach diagnosing findings highlight promise utilizing exosomal novel markers ICNSs, which may implications improving patient outcomes disease management.
Language: Английский
Citations
0
Brain Research, Journal Year: 2025, Volume and Issue: unknown, P. 149590 - 149590
Published: March 1, 2025
Language: Английский
Citations
0