Bibliometrics of trends in global research on the roles of stem cells in myocardial fibrosis therapy DOI
Jingyi Ding,

Tiantian Meng,

Rui Du

et al.

World Journal of Stem Cells, Journal Year: 2024, Volume and Issue: 16(12), P. 1086 - 1105

Published: Dec. 12, 2024

BACKGROUND Myocardial fibrosis, a condition linked to several cardiovascular diseases, is associated with poor prognosis. Stem cell therapy has emerged as potential treatment option and the application of stem been studied extensively. However, comprehensive bibliometric analysis these studies yet be conducted. AIM To map thematic trends, analyze research hotspots, project future directions cell-based myocardial fibrosis therapy. METHODS We conducted visual in Web Science Core Collection using VOSviewer Microsoft Excel. The dataset included 1510 articles published between 2001 2024. Countries, organizations, authors, references, keywords, co-citation networks were examined identify evolving trends. RESULTS Our findings revealed steady increase number publications, projected over 200 publications annually by 2030. Initial focused on therapy, particularly for infarction heart failure. More recently, there shift toward cell-free involving extracellular vesicles, exosomes, microRNAs. Key topics include angiogenesis, inflammation, apoptosis, autophagy, oxidative stress. CONCLUSION This highlights evolution therapies emerging interest approaches. These results are expected guide scientific exploration decision-making.

Language: Английский

Recent advances in adipose-derived mesenchymal stem cell-derived exosomes for regulating macrophage polarization DOI Creative Commons
Zhihui Dong, Yingli Fu, Zhongming Cai

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 3, 2025

Adipose-derived mesenchymal stem cells (ADSCs) exhibit superior immunomodulatory properties and have broad therapeutic applications. They induce macrophage M2 polarization for anti-inflammatory responses. Exosomes derived from ADSCs (ADSC-EXOs) biological functions similar to those of but can circumvent the limitations associated with cellular injection therapies. Potent substances contained in exosomes include glycoprotein MFGE8, cytokines such as prostaglandin E2, IL-6, IGF, well non-coding nucleotides (miR-451a, miR-23, miR-30d-5p, let-7, lncRNA DLEU2, circRps5, Circ-Ptpn4, mmu_ circ_0001359). The these provide new perspectives approaches graft inflammation, bone healing, acute lung injury, kidney stones, myocardial infarction, diabetes-related diseases. This review summarizes contents ADSC-EXOs, outlines their characteristics phenotypes, emphasizes impact on contribution immune-related

Language: Английский

Citations

2
Recent advances and future prospects of engineered exosomes as advanced drug and gene delivery systems DOI
Waleed Y. Rizg, Majed Alghamdi, Sherif El Saadany

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: 106, P. 106696 - 106696

Published: Feb. 6, 2025

Language: Английский

Citations

1
Inflammatory Cell-Targeted Delivery Systems for Myocardial Infarction Treatment DOI Creative Commons
Wenyuan Zhang, Dan Peng, Shiqi Cheng

et al.

Bioengineering, Journal Year: 2025, Volume and Issue: 12(2), P. 205 - 205

Published: Feb. 19, 2025

Myocardial infarction (MI) is a cardiovascular disease (CVD) with high morbidity and mortality worldwide, which serious threat to human life health. Inflammatory immune responses are initiated immediately after MI, unbalanced inflammation post-MI can lead cardiac dysfunction, scarring, ventricular remodeling, emphasizing the critical need for an effective inflammation-regulating treatment. With development of novel therapies, drug delivery system specific inflammatory cells offers significant potential. In this review, we introduce fibroblasts involved in MI summarize newly developed systems related use injectable hydrogels, patches, nanoparticles, extracellular vesicles (EVs). Finally, highlight recent trends cell-targeting involving different strategies that facilitate treatment MI.

Language: Английский

Citations

0
Macrophage-driven exosomes regulate the progression of cardiovascular disease DOI Creative Commons
Qi Liao, Dan Luo, Hongyan Li

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 30, 2025

Exosomes, as vital mediators of intercellular communication, play a critical role in the progression cardiovascular disease (CVD). Recently, macrophage-derived exosomes (Mφ-Exos) have garnered increasing attention because their significant potential early diagnosis, pathological processes, and therapeutic applications for CVD. Exosomes contain diverse nucleic acids (e.g., miRNAs, mRNAs, long noncoding RNAs (lncRNAs)) proteins, which serve specific biomarkers that regulate various stages For example, miRNAs encapsulated within miR-21, miR-133a, miR-155) are closely associated with atherosclerosis, myocardial infarction, coronary artery disease, stroke, changes abundance can diagnostic prognostic indicators. Additionally, composition Mφ-Exos, including lipids, plays initiation, progression, inflammation Research on Mφ-Exos provides new directions mechanistic exploration, novel targets However, challenges remain regarding exosome isolation identification technologies. Future studies need to further explore biological properties develop more efficient, economical, straightforward methods. This review summarizes multifaceted regulatory roles CVD, encompassing key processes such inflammation, angiogenesis, metabolism, cell death. has shown M1-Exos promote exacerbation CVD through pro-inflammatory pro-fibrotic mechanisms, while M2-Exos demonstrate via anti-inflammatory, pro-angiogenic, metabolic reprogramming pathways. These findings not only reveal complex mechanisms but also provide perspectives diagnosis precision treatment disease.

Language: Английский

Citations

0
Thermosensitive Hydrogel Integrated with Bimetallic Nano‐Enzymes for Modulating the Microenvironment in Diabetic Wound Beds DOI Creative Commons

Chuwei Zhang,

Xiaoyi Zhang, Fei Li

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Abstract Effective regulation and reconstruction of the microenvironment are critical for regeneration chronic wounds. Diabetic wounds, in particular, pose a significant clinical challenge due to increased oxidative stress dysfunctional healing processes. In this study, novel therapeutic strategy is developed using 3D copper‐magnesium bimetallic antioxidant nano‐enzymes (Cu/Mg‐MOF) mitigate reactive oxygen species (ROS) restore redox balance through electron transfer. To optimize delivery, thermo‐sensitive hydrogel composed chitosan (CS) ε ‐polylysine (PL) designed, serving as an efficient carrier nano‐enzymes. This Cu/Mg‐MOF@CS/PL exhibits excellent physical properties, including injectability, softness, biocompatibility, making it ideal application diabetic wound model, treatment with significantly accelerated healing, closure rate 90.6% by day 14, compared just 55.4% untreated group. The effectively promoted key aspects such collagen deposition, re‐epithelialization, angiogenesis, immunomodulation. These findings underscore potential promising system enhancing

Language: Английский

Citations

1
Cardiac cells and mesenchymal stem cells derived extracellular vesicles: a potential therapeutic strategy for myocardial infarction DOI Creative Commons

Dan Qin,

Xiaobo Wang, Jun Pu

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Dec. 18, 2024

Despite improvements in clinical outcomes of acute myocardial infarction (AMI), mortality rates remain high, indicating the need for further understanding pathogenesis and developing more effective cardiac protection strategies. Extracellular vesicles (EVs) carry proteins noncoding RNAs (ncRNAs) derived from different cell populations, mainly including cardiomyocytes, endothelial cells, progenitor cardiosphere-derived immune fibroblasts telocytes have vital roles under both physiological pathological process such as (MI). The content EVs can also indicate status their parental cells serve a biomarker monitoring risk injury. Examining these offer fresh perspectives on development MI assist creating innovative treatments. Additionally, mesenchymal stem (MSCs) (MSC-EVs) been shown to significant potential regeneration. In this review, we will discuss current role communication, with focus various MSCs uses therapies after MI.

Language: Английский

Citations

1
Engineering extracellular vesicles for targeted therapeutics in cardiovascular disease DOI Creative Commons
Enze Fu, Kai Pan, Zongjin Li

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Dec. 19, 2024

Extracellular vesicles (EVs) are nanosized particles secreted by cells that play crucial roles in intercellular communication, especially the context of cardiovascular diseases (CVDs). These carry complex cargo, including proteins, lipids, and nucleic acids, reflects physiological or pathological state their origin. Multiomics analysis cell-derived EVs has provided valuable insights into molecular mechanisms underlying CVDs identifying specific proteins EV-bound targets involved disease progression. Recent studies have demonstrated engineered EVs, which designed to therapeutic molecules modified enhance targeting capabilities, hold promise for treating CVDs. Analysis EV proteome been instrumental key can be targeted modulated within these vesicles. For example, inflammation, thrombosis, cardiac remodeling identified as potential targets. Furthermore, engineering increase delivery tissues, such myocardium, modulate immunogenicity efficacy is an emerging area research. By leveraging gained from multiomics analyses, researchers developing EV-based therapies selectively target processes CVDs, offering a novel potentially more effective treatment strategy. This review integrates core findings highlights applications.

Language: Английский

Citations

1
Bibliometrics of trends in global research on the roles of stem cells in myocardial fibrosis therapy DOI
Jingyi Ding,

Tiantian Meng,

Rui Du

et al.

World Journal of Stem Cells, Journal Year: 2024, Volume and Issue: 16(12), P. 1086 - 1105

Published: Dec. 12, 2024

BACKGROUND Myocardial fibrosis, a condition linked to several cardiovascular diseases, is associated with poor prognosis. Stem cell therapy has emerged as potential treatment option and the application of stem been studied extensively. However, comprehensive bibliometric analysis these studies yet be conducted. AIM To map thematic trends, analyze research hotspots, project future directions cell-based myocardial fibrosis therapy. METHODS We conducted visual in Web Science Core Collection using VOSviewer Microsoft Excel. The dataset included 1510 articles published between 2001 2024. Countries, organizations, authors, references, keywords, co-citation networks were examined identify evolving trends. RESULTS Our findings revealed steady increase number publications, projected over 200 publications annually by 2030. Initial focused on therapy, particularly for infarction heart failure. More recently, there shift toward cell-free involving extracellular vesicles, exosomes, microRNAs. Key topics include angiogenesis, inflammation, apoptosis, autophagy, oxidative stress. CONCLUSION This highlights evolution therapies emerging interest approaches. These results are expected guide scientific exploration decision-making.

Language: Английский

Citations

0