Environmental Toxicology and Pharmacology, Journal Year: 2022, Volume and Issue: 97, P. 104032 - 104032
Published: Dec. 5, 2022
Language: Английский
International Journal of Hygiene and Environmental Health, Journal Year: 2022, Volume and Issue: 247, P. 114057 - 114057
Published: Oct. 31, 2022
Perfluoroalkyl substances (PFAS) are man-made fluorinated chemicals, widely used in various types of consumer products, resulting their omnipresence human populations. The aim this study was to describe current PFAS levels European teenagers and investigate the determinants serum/plasma concentrations specific age group.
Language: Английский
Citations
63
International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(11), P. 6787 - 6787
Published: June 1, 2022
Human biomonitoring has become a pivotal tool for supporting chemicals’ policies. It provides information on real-life human exposures and is increasingly used to prioritize chemicals of health concern evaluate the success chemical Europe launched ambitious REACH program in 2007 improve protection environment. In October 2020 EU commission published its new strategy sustainability towards toxic-free The European Parliament called upon collect data support chemical’s risk assessment management. This manuscript describes organization first HBM4EU-aligned studies that obtain comparable (HBM) citizens monitor their internal exposure environmental chemicals. build existing HBM capacity by aligning national or regional studies. focus three age groups: children, teenagers, adults. participants are recruited between 2014 2021 11 12 primary sampling units geographically distributed across Europe. Urine samples collected all groups, blood children teenagers. Auxiliary socio-demographics, lifestyle, status, environment, diet using questionnaires. total, biological from 3137 aged 6–12 years analysis biomarkers phthalates, HEXAMOLL® DINCH, flame retardants. Samples 2950 teenagers 12–18 Hexamoll® per- polyfluoroalkyl substances (PFASs), 3522 adults 20–39 cadmium, bisphenols, metabolites polyaromatic hydrocarbons (PAHs). children’s group consists 50.4% boys 49.5% girls, which 44.1% live cities, 29.0% towns/suburbs, 26.8% rural areas. teenagers’ includes 50.6% girls 49.4% boys, with 37.7% residents 31.2% 30.2% adult 52.6% women 47.4% men, 71.9% 14.2% only 13.4% study population approaches characteristics general based age-matched EUROSTAT EU-28, 2017 data; however, individuals who obtained no lower educational level (ISCED 0–2) underrepresented. priority this unique cohort will provide baseline Europe’s non-toxic environment challenges recommendations frame future EU-wide surveys discussed.
Language: Английский
Citations
55
Chemosphere, Journal Year: 2022, Volume and Issue: 313, P. 137530 - 137530
Published: Dec. 9, 2022
Per- and polyfluoroalkyl substances (PFAS) are persistent organic pollutants. The first exposure to PFAS occurs in utero, after birth it continues via breast milk, food intake, environment, consumer products that contain these chemicals. Our aim was identify determinants of concentrations sensitive population subgroups– pregnant women newborns. Nine European cohorts provided data on (INMA-Gipuzkoa, Sabadell, Valencia, ELFE MoBa; total N = 5897) or newborns (3xG study, FLEHS 2, 3 PRENATAL; 940). PFOS, PFOA, PFHxS PFNA were measured maternal cord blood, depending the cohort (FLEHS 2 only PFOS PFOA). analysed according characteristics (age, BMI, parity, previous breastfeeding, smoking, consumption during pregnancy) parental educational level. association between potential evaluated using multiple linear regression models. We observed significant variations among cohorts. Higher associated with higher age, primipara birth, level, both for blood blood. fish seafood, meat, offal eggs. In daily meat consumption. Daily milk dairy lower both, High detection rates four most abundant demonstrate ubiquitous populations, which is concern. This study identified several newborns, including dietary factors, findings can be used proposing measures reduce exposure, particularly from sources.
Language: Английский
Citations
45
Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(24), P. 10470 - 10481
Published: June 6, 2024
Rural workers are disproportionally exposed to pesticides and might be at an increased risk of developing chronic diseases. Here, we investigated the impact pesticide exposure on breast cancer (BC) disease profile in rural female workers. This is a case-control study that prospectively included 758 individuals. The was conducted Southwest region Paraná state Brazil, characterized by family-based agriculture intensive use pesticides. We found this has 41% higher BC diagnosis rate 14% mortality than mean rates as well trade volume about 6 times national average. showed substantial population even women who did not work fields but performed equipment decontamination clothes washing male partners worked had urine samples positive for glyphosate, atrazine, and/or 2,4-D. crude association significantly among (OR: 1.58, 95% CI 1.18–2.13). Adjusted analyses lower nonstatistically significant 1.30, 41 0.87–1.95). Stratification lymph node metastasis (adjusted OR: 2.19, 1.31–3.72) Our findings suggest populations with more aggressive draw attention need monitor potentially field or home.
Language: Английский
Citations
7
Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1321, P. 139974 - 139974
Published: Sept. 7, 2024
Language: Английский
Citations
5
International Journal of Hygiene and Environmental Health, Journal Year: 2022, Volume and Issue: 246, P. 114050 - 114050
Published: Sept. 1, 2022
Language: Английский
Citations
22
Toxics, Journal Year: 2022, Volume and Issue: 10(12), P. 789 - 789
Published: Dec. 15, 2022
Currently used pesticides are rapidly metabolised and excreted, primarily in urine, urinary concentrations of pesticides/metabolites therefore useful biomarkers for the integrated exposure from all sources. Pyrethroid insecticides, organophosphate insecticide chlorpyrifos, herbicide glyphosate, were among prioritised substances HBM4EU project comparable human biomonitoring (HBM)-data obtained Aligned Studies. The aim this review was to supplement these data by presenting additional HBM studies priority across partner countries published since 2000. We identified relevant (44 pyrethroids, 23 24 glyphosate) literature search using PubMed Web Science. Most Western Southern part EU lacking more than half HBM4EU-partner countries. Many regional with relatively small sample size few address residential occupational exposure. Variation urine sampling, analytical methods, reporting HBM-data hampered comparability results studies. Despite shortcomings, a widespread general population marked geographical differences indicated. findings emphasise need harmonisation methods future as initiated during HBM4EU.
Language: Английский
Citations
17
International Journal of Hygiene and Environmental Health, Journal Year: 2023, Volume and Issue: 251, P. 114196 - 114196
Published: June 1, 2023
Adolescence is a period of significant physiological changes, and likely sensitive window to chemical exposure. Few nation-wide population-based studies body burdens in adolescents have been published. In the national dietary survey Riksmaten Adolescents (RMA) 2016–17, over 13 substance groups, including elements, chlorinated/brominated/fluorinated persistent organic pollutants (POPs) were analysed blood, urine metabolites phthalates/phthalate alternatives, phosphorous flame retardants, polycyclic aromatic hydrocarbons (PAHs), pesticides, along with bisphenols biocide/preservative/antioxidant/UV filter substances (N = 1082, ages 11–21). The aim was characterize representative population Sweden, compare results human biomonitoring guidance values (HBM-GVs). Cluster analyses Spearman's rank order correlations suggested that concentrations known common exposure sources similar toxicokinetics formed obvious clusters showed moderate very strong (r ≥ 0.4). No between from different matrices. Geometric mean (GM) generally less than 3-fold those observed among NHANES (USA 2015–16) GerES V (Germany 2014–17). Notable exceptions brominated diphenyl ethers (PBDEs) >20-fold lower GM concentrations, biocide triclosan ultraviolet (UV) benzophenone-3 >15-fold RMA compared NHANES. Exceedance most conservative HBM-GVs for aluminium (Al, 26% subjects), perfluorooctanesulfonic acid (PFOS, 19%), perfluorooctanoic (PFOA, 12%), lead (Pb, MBP (dibutyl phthalate metabolite, 4.8%), hexachlorobenzene (HCB, 3.1%) 3-phenoxybenzoic (PBA, pyrethroid 2.2%). Males higher proportion exceedances females Pb, HCB PFOS; otherwise no gender-related differences observed. A males had Hazard Index (HI) liver kidney toxicity neurotoxicity >1. Industrialized countries similarly high standards living, some exceptions, show comparable average variety toxic chemicals general population. HIs strongly suggests further efforts limit are warranted.
Language: Английский
Citations
11
International Journal of Hygiene and Environmental Health, Journal Year: 2023, Volume and Issue: 254, P. 114265 - 114265
Published: Sept. 1, 2023
Esteban is a nationwide cross-sectional study conducted in France 2014–2016, including 2503 adults aged 18–74 years old and 1104 children 6–17 old, as part of the French Human Biomonitoring programme. The present paper describes biological levels five families pesticides analysed on random sub-samples 900 500 for urine concentrations, 759 255 serum determinants exposure. Organophosphates, carbamates herbicides were measured by UPLC-MS/MS; chlorophenols pyrethroids GC-MS/MS; specific organochlorines GC-HRMS. Multivariate analyses performed to identify exposure using generalized linear model. Pyrethroid metabolites quantified 99% children, with exeption F-PBA, which was 31% 27% respectively. Carbamates some organophosphates barely or not quantified. DMTP 82% 93% γ-HCH (lindane) almost 50% children. Concentration pesticide biomarkers consistent comparable international studies, except β-HCH, DMTP, deltamethrin metabolite Br2CA, whose sometimes higher France. Household insecticide use smoking also associated pyrethroids. All concentration below existing health-based HBM guidance values, HBM-GVsGenPop, 3-PBA, approximately 1% 10% above lower upper threshold values 22 μg/L 6.4 μg/L, provides description 70 first time It adults, glyphosate AMPA. For latter, overall than adults. Our results highlight possible beneficial impact regulations adult organochlorine organophosphate between 2006 2016, decreased over this period.
Language: Английский
Citations
11
Toxics, Journal Year: 2023, Volume and Issue: 11(10), P. 819 - 819
Published: Sept. 28, 2023
Human biomonitoring (HBM) data in Europe are often fragmented and collected different EU countries sampling periods. Exposure levels for children adult women were evaluated over time. For the period 2000–2010, literature aggregated a harmonized way across studies. Between 2011–2012, biobanked samples from DEMOCOPHES project used. 2014–2021, HBM generated within HBM4EU Aligned Studies. Time patterns on internal exposure visually statistically using 50th 90th percentiles (P50/P90) phthalates/DINCH organophosphorus flame retardants (OPFRs) (5–12 years), cadmium, bisphenols polycyclic aromatic hydrocarbons (PAHs) (24–52 years). Restricted phthalate metabolites show decreasing children. Phthalate substitute, DINCH, shows non-significant increasing pattern. OPFRs, no trends significant. women, BPA clear pattern, while substitutes BPF BPS an pattern coinciding with restrictions introduced. No observed PAHs or cadmium. Although causal relations not studied as such, to chemicals restricted at level decreased, some of their increased. The results support policy efficacy monitoring policy-supportive role played by HBM.
Language: Английский
Citations
11