SARS-COV-2 re-infection and incidence of post-acute sequelae of COVID-19 (PASC) among essential workers in New York: a retrospective cohort study

The Lancet Regional Health - Americas, Journal Year: 2025, Volume and Issue: 42, P. 100984 - 100984

Published: Jan. 8, 2025

Language: Английский

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Targeting the SARS-CoV-2 reservoir in long COVID

The Lancet Infectious Diseases, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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Long COVID’s Impact on Patients, Workers, & Society: A review

Medicine, Journal Year: 2024, Volume and Issue: 103(12), P. e37502 - e37502

Published: March 22, 2024

The incidence of long COVID in adult survivors an acute SARS-CoV-2 infection is approximately 11%. Of those afflicted, 26% have difficulty with day-to-day activities. majority COIVD cases occur after mild or asymptomatic infection. Children can spread infections and also develop long-term neurological, endocrine (type I diabetes), immunological sequelae. Immunological hypofunction exemplified by the recent large outbreaks respiratory syncytial virus streptococcal infections. Neurological manifestations are associated anatomical brain damage demonstrated on scans autopsy studies. prefrontal cortex particularly susceptible. Common symptoms include fog, memory loss, executive dysfunction, personality changes. impact society has been profound. Fewer than half previously employed adults who working full-time, 42% patients reported food insecurity 20% difficulties paying rent. Vaccination not only helps prevent severe COVID-19, but numerous studies found beneficial effects preventing mitigating COVID. There evidence that vaccination lessen Physical occupational therapy help regain function, approach must be "low slow." Too much physical mental activity result post-exertional malaise set back recovery process days weeks. complexity presentations coupled rampant organized disinformation, caused significant segments public to ignore sound health advice. Further research needed regarding treatment effective communication.

Language: Английский

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Persisting Shadows: Unraveling the Impact of Long COVID-19 on Respiratory, Cardiovascular, and Nervous Systems

Infectious Disease Reports, Journal Year: 2023, Volume and Issue: 15(6), P. 806 - 830

Published: Dec. 15, 2023

The coronavirus disease 2019 (COVID-19), instigated by the zoonotic Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), rapidly transformed from an outbreak in Wuhan, China, into a widespread global pandemic. A significant post-infection condition, known as 'long- COVID-19' (or simply COVID'), emerges substantial subset of patients, manifesting with constellation over 200 reported symptoms that span multiple organ systems. This also 'post-acute sequelae SARS-CoV-2 infection' (PASC), presents perplexing clinical picture far-reaching implications, often persisting long after acute phase. While initial research focused on immediate pulmonary impact virus, recognition COVID-19 multiorgan disruptor has unveiled gamut protracted and severe health issues. review summarizes primary effects COVID respiratory, cardiovascular, nervous It delves mechanisms underlying these impacts underscores critical need for comprehensive understanding COVID's pathogenesis.

Language: Английский

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Impact of COVID-19 vaccination on symptoms and immune phenotypes in vaccine-naïve individuals with Long COVID

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 12, 2024

Abstract Background Long COVID contributes to the global burden of disease. Proposed root cause hypotheses include persistence SARS-CoV-2 viral reservoir, autoimmunity, and reactivation latent herpesviruses. Patients have reported various changes in symptoms after COVID-19 vaccinations, leaving uncertainty about whether vaccine-induced immune responses may alleviate or worsen disease pathology. Methods In this prospective study, we evaluated vaccination 16 vaccine-naïve individuals with COVID. Surveys were administered before then at 2, 6, 12 weeks receiving first vaccine dose primary series. Simultaneously, SARS-CoV-2-reactive TCR enrichment, SARS-CoV-2-specific antibody responses, other self-antigens, circulating cytokines quantified 6 vaccination. Results Self-report post-vaccination indicated 10 out participants had improved health, 3 no change, 1 worse 2 marginal changes. Significant elevation TCRs Spike protein-specific IgG observed No reactivities against herpes viruses self-antigens. Within dataset, higher baseline sIL-6R was associated symptom improvement, two top features non-improvement high IFN-β CNTF, among soluble analytes. Conclusions Our study showed that small sample, health resulted change most participants, though few experienced worsening. Vaccination increased T cell expansion Symptom improvement those elevated sIL-6R, while interferon neuropeptide levels a lack improvement. Plain language summary The impact on suffering from is uncertain. This assessed experience signatures unvaccinated A total status vaccination, one person only worsening health. As expected, cells antibodies spike protein. Immune prove be predictors However, given number these initial findings need further validation.

Language: Английский

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UB-612 pan-SARS-CoV-2 T cell immunity-promoting vaccine protects against COVID-19 moderate-severe disease

iScience, Journal Year: 2024, Volume and Issue: 27(2), P. 108887 - 108887

Published: Jan. 20, 2024

Language: Английский

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Translating insights into therapies for Long Covid

Science Translational Medicine, Journal Year: 2024, Volume and Issue: 16(773)

Published: Nov. 13, 2024

Long Covid is defined by a wide range of symptoms that persist after the acute phase severe respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Commonly reported include fatigue, weakness, postexertional malaise, and cognitive dysfunction, with many other reported. Symptom range, duration, severity are highly variable partially overlap myalgic encephalomyelitis/chronic fatigue post-acute infectious syndromes, highlighting opportunities to define shared mechanisms pathogenesis. Potential diverse, including persistence viral reservoirs, dysregulated immune responses, direct damage tissues targeted SARS-CoV-2, inflammation driven reactivation latent infections, vascular endothelium activation or subsequent thromboinflammation, autoimmunity, metabolic derangements, microglial activation, microbiota dysbiosis. The heterogeneity baseline characteristics people Covid, as well varying states immunity therapies given at time infection, have made etiologies difficult determine. Here, we examine progress on preclinical models for review being in clinical trials, need large human studies further development better understand Covid. Such will inform trials treatments benefit those living this condition.

Language: Английский

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Positionspapier zum Post-COVID-Syndrom

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

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Altered Circulating Cytokine Profile Among mRNA‐Vaccinated Young Adults: A Year‐Long Follow‐Up Study

Immunity Inflammation and Disease, Journal Year: 2025, Volume and Issue: 13(4)

Published: April 1, 2025

ABSTRACT Objectives This longitudinal study aimed to assess the impact of COVID‐19 vaccination on cytokine profile. Methods A total 84 Saudi subjects (57.1% females) with mean age 27.2 ± 12.3 participated in this study. Anthropometric data and fasting blood samples were obtained at baseline after final vaccination, an average follow‐up duration 14.1 3.6 months for adolescents 13.3 3.0 adults, calculated from first dose vaccination. Assessment profiles was done using commercially available assays. Results After follow‐up, a significant increase weight body mass index observed overall ( p = 0.003 0.002, respectively). Postvaccination, increases several cytokines, including basic fibroblast growth factor 2 < 0.001), interferon gamma (IFNγ) 0.005), interleukin‐1 beta (IL1β) IL4 IL6 0.003), IL7 IL17E monocyte chemoattractant protein‐1 (MCP1) 0.03), MCP3 tumor necrosis alpha (TNFα) VEGFA 0.001). reduction only macrophage colony‐stimulating When adjusted age, epidermal (EGF), IL4, IL6, MCP3, TNFα, vascular endothelial (VEGFA) remained statistically significant. Gender‐based analysis revealed that men experienced greater 0.008), 0.04), TNFα 0.015) compared women. Age‐based showed older participants had more pronounced EGF 0.011), 0.029), MCP1 0.042), 0.017), while younger 0.025). Conclusions The findings indicated resulted levels, which signifies persistence humoral immune response messenger RNA (mRNA) vaccines. effect may be attributed persistent production spike protein highly inflammatory nature mRNA–lipid nanoparticle. Additionally, results suggested differences levels based gender age. Notably, profile remains favorably altered young adults who received mRNA vaccinations, even 1 year.

Language: Английский

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Multidisciplinary collaborative guidance on the assessment and treatment of patients with Long COVID: A compendium statement

PM&R, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

Abstract Background In 2021, the American Academy of Physical Medicine and Rehabilitation established Multi‐Disciplinary Post‐Acute Sequelae SARS‐CoV‐2 Infection Collaborative to provide guidance from Long COVID clinics for evaluation management COVID. The collaborative previously published eight consensus statements using a primarily symptom‐based approach. However, symptoms most often do not occur in isolation. Aims This compendium aims equip clinicians with an efficient, up‐to‐date clinical resource evaluating managing adults experiencing symptoms. primary intended audience includes physiatrists, care physicians, other who first‐line assessment symptoms, especially settings where subspecialty is readily available. provides holistic framework management, symptom‐specific considerations, updates on prevalence, health equity, disability pathophysiology, emerging evidence regarding treatments under investigation. Because closely resembles infection‐associated chronic conditions (IACCs) such as myalgic encephalomyelitis/chronic fatigue syndrome, this may also be helpful these related conditions. Methods Guidance was developed by collaborative's modified Delphi multidisciplinary group whose members include pulmonologists, cardiologists, psychiatrists, neuropsychologists, neurologists, occupational therapists, physical speech language pathologists, patients, government representatives. Over 40 centers are represented collaborative. Results defined National Academies Sciences, Engineering, “an IACC that occurs after infection present at least 3 months continuous, relapsing remitting, or progressive disease state affects one more organ systems.” current global prevalence estimated 6%. Higher has been identified among female gender, certain racial ethnic groups, individuals live nonurban areas. anyone can develop being infected virus. wide variety symptom clusters. common exaggerated diminished energy windows, postexertional malaise (PEM)/postexertional exacerbation (PESE), cognitive impairment (brain fog), dysautonomia, pain/myalgias, smell taste alterations. Holistic should traditional history, examination, additional diagnostic testing, indicated. A positive COVID‐19 test during acute required diagnose COVID, currently, there no single laboratory finding definitively confirming ruling out diagnosis basic recommended all patients possible consideration labs procedures guided patient's specific Current strategies focus supportive care. Critical considerations conservation addressing comorbidities modifiable risk factors. Additionally, (1) it essential validate experience reassurance their taken seriously because many have had dismissed loved ones clinicians; (2) activity recommendations must carefully tailored tolerance overly intense trigger PEM/PESE worsened muscle damage; (3) treatment delivered humility persistent unknowns To date, limited data guide medication specifically context As such, use generally follows standard practice indications dosing, extra attention prioritize patient preference via shared decision‐making cautious medications improve some (eg, cognitive/attention impairment) but worsen PEM/PESE). Numerous trials investigating treatments. return‐to‐work process challenging fluctuate, vary nature, affect multiple functional areas cognitive), manifest “invisible disability” acknowledged employers coworkers. Clinicians help return work identifying suitable workplace accommodations resources, providing necessary documentation, recommending vocational therapy when needed. If efforts unsuccessful significantly worsens impedes recovery, applying warranted. recognized potential Americans Disabilities Act. Conclusion contribute overall well‐being manner acknowledges challenges faced uncertainties field. For detailed information readers reference statements.

Language: Английский

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