Pediatru ro, Journal Year: 2024, Volume and Issue: 3(75), P. 22 - 22
Published: Jan. 1, 2024
Diagnostics, Journal Year: 2024, Volume and Issue: 14(7), P. 711 - 711
Published: March 28, 2024
Four years post-pandemic, SARS-CoV-2 continues to affect many lives across the globe. An estimated 65 million people suffer from long COVID, a term used encapsulate post-acute sequelae of infections that multiple organ systems. Known symptoms include chronic fatigue syndrome, brain fog, cardiovascular issues, autoimmunity, dysautonomia, and clotting due inflammation. Herein, we review COVID symptoms, proposed theories behind pathology, diagnostics, treatments, clinical trials underway explore treatments for viral persistence, autonomic cognitive dysfunctions, sleep disturbances, fatigue, exercise intolerance.
Language: Английский
Citations
11
Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)
Published: Aug. 16, 2024
The prevalence of chronic kidney disease (CKD) is on the rise, posing a significant public health challenge. Although gut microbiome dysbiosis has been implicated in impairment functions, existence pathological subtypes-linked differences remains largely unknown. We aimed to characterize intestinal microbiota patients with membranous nephropathy (MN), IgA (IgAN), minimal change (MCD), and ischemic renal injury (IRI) order investigate intricate relationship between CKD across different subtypes. conducted cross-sectional study involving 94 various patterns 54 healthy controls (HCs). clinical parameters were collected, stool samples obtained from each participant. Gut microbial features analyzed using 16S rRNA sequencing taxon annotation compare HC, CKD, MN, IgAN, MCD, IRI groups. subjects exhibited significantly reduced alpha diversity, modified community structures, disrupted composition potential functions compared control group. opportunistic pathogen Klebsiella enrichment whereas Akkermansia showed higher abundance HCs. further revealed presence heterogeneity signatures diverse types, including IRI. depression family Lachnospiraceae genus Bilophila was prominently observed exclusively while suppressed Streptococcus detected only individuals remarkable expansion Escherichia uniquely found cases also encompassed development classifiers employing diagnostic markers accurately discriminate distinct subtypes CKD. dysregulation strongly correlated exhibiting specificity towards patterns. Our emphasizes significance considering when assessing impact development, diagnosis, treatment
Language: Английский
Citations
4
Reviews in Medical Virology, Journal Year: 2025, Volume and Issue: 35(2)
Published: Feb. 24, 2025
Long-COVID affects a significant number of COVID-19 survivors, profoundly impacting daily life and work. Although research suggests potential link between antibody levels long-COVID risk, findings remain inconclusive. Understanding dynamics could support the identification patients at improve diagnosis, guide protective strategies such as vaccination. Despite growing evidence, no systematic review has yet evaluated current literature on this topic. We therefore aimed to synthesise evaluate existing evidence association anti-SARS-CoV-2 titres long-COVID, with goal clarifying their role in predicting guiding patient management, informing future directions. Studies published PubMed/Medline databases January 2020 October 2024 were included without language restrictions. body fluids other than serum/blood excluded. Study selection quality assessment was conducted independently by two researchers. After screening 949 studies, 58 studies encompassing 53,739 individuals, 7812 patients, included. Evidence highly heterogenous but most reported an anti-SARS-CoV-2-spike antibodies although nature appeared be dependent time from acute infection. Low during associated increased risk long-COVID. The low that maintaining sufficiently high may protective. However, level is further sufficient power are required confirm potentially determine cutoffs.
Language: Английский
Citations
0
Diagnostics, Journal Year: 2024, Volume and Issue: 14(11), P. 1168 - 1168
Published: May 31, 2024
Long COVID, characterized by a persistent symptom spectrum following SARS-CoV-2 infection, poses significant health, social, and economic challenges. This review aims to consolidate knowledge on its epidemiology, clinical features, underlying mechanisms guide global responses;
Language: Английский
Citations
3
Stem Cell Reviews and Reports, Journal Year: 2024, Volume and Issue: 20(8), P. 2062 - 2103
Published: Aug. 16, 2024
Language: Английский
Citations
3
Published: April 26, 2024
Background: Long COVID, characterized by a persistent symptom spectrum following SARS-CoV-2 infection, poses significant health, social, and economic challenges. This review aims to consolidate knowledge on its epidemiology, clinical features, underlying mechanisms guide global responses; Methods: We conducted systematic literature review, analyzing peer-reviewed articles reports gather comprehensive data long COVID’s symptomatology, management approaches; Results: Our analysis revealed wide array of COVID symptoms risk factors, with notable demographic variability. The current understanding pathophysiology suggests multifactorial origin yet remains partially understood. Emerging diagnostic criteria potential therapeutic strategies were identified, highlighting advancements in management.; Conclusion: highlights the multifaceted nature revealing broad symptoms, diverse complex interplay physiological underpinning condition. disorders will continue weigh healthcare systems years come. Ad-dressing requires holistic strategy that integrates care, social support, policy initiatives. findings underscore need for increased international cooperation research health planning address challenges COVID. There is call continued refinement treatment modalities, emphasizing multidisciplinary approach manage ongoing evolving impacts
Language: Английский
Citations
2
Klinische Pädiatrie, Journal Year: 2024, Volume and Issue: unknown
Published: May 31, 2024
Abstract Background Following the pandemic of COVID-19, main focus has been on COVID-19 vaccines and herd immunity. Although safety shown in clinical trials, children with chronic diseases were not included. We investigated side effect profile adolescents kidney disease. Methods A questionnaire including demographic information, history vaccination status, vaccine-related effects was administered to patients disease (CKD) stage 2–5, glomerular treated immunosuppression, transplant recipients. Results Ninety-eight vaccinated CoronaVac-inactivated SARS-CoV-2 (n=16) or BNT162b2 messenger RNA (mRNA) COVİD-19 (n=82) vaccine. The mean age 16.90±2.36 years. most common local pain, fatigue, fever. No serious renal flare observed. There no significant difference reported after mRNA-RNA as compared Corona Vac-inactivated relationship found between frequency according age, filtration rate, immunosuppressive treatments, CKD stage, underlying Conclusion data are subjective because they obtained through a studies long-term follow-up needed, our early experience suggests that vaccine is safe young adults should be encouraged vaccinated.
Language: Английский
Citations
0
Ukrainian Journal of Nephrology and Dialysis, Journal Year: 2024, Volume and Issue: 3(83), P. 68 - 78
Published: Aug. 3, 2024
Термінальна стадія хронічної хвороби нирок, яка потребує лікування методом гемодіалізу (ХХН VГД), є критичною глобальною проблемою охорони здоров'я, ще більше ускладнилась пандемією COVID-19. Хоча відомо, що постковідний синдром (ПКС) погіршує якість життя ГД пацієнтів, його вплив на смертність залишається маловивченим. Метою цього дослідження було проаналізувати хворих ХХН VГД з ПКС та визначити її клінічні лабораторні детермінанти. Методи. Це багатоцентрове, проспективне включало пацієнтів чотирьох діалізних центрів України, які перенесли COVID-19 станом кінець березня 2022 року. Зібрані дані включали демографічні, параметри і наявність ПКС. Основними кінцевими точками були у хворих, асоційована або без нього. Результати. З 465 353 відповідали критеріям включення. був діагностований 222 (62,9%), який асоціювався чоловічою статтю, старшим віком, діабетом, тимчасовим судинним доступом, вищим індексом Чарлсона, нижчими показниками Kt/V, гемоглобіну альбуміну, вищими балами CONUT підвищеними рівнями СРБ. Протягом двох років спостереження зареєстровано 38 (11,4%) летальних випадків; основними причинами смерті серцево-судинні події (42,2%) інфекційні ускладнення (21,1%). Багатофакторний регресійний аналіз Кокса визначив, старший вік (OR 1,32, 95% CI 1,03; 1,66), тривалість діалізу 1,86, 1,77; 1,97), діабет 3,57, 1,81; 7,06), вища коморбідність 4,22, 2,11; 7,82), гірший нутритивний статус 1,66, 1,08; 12,3), тимчасовий судинний доступ 1,88, 1,16; 3,86), високий артеріальний тиск 1,37, 1,82) рівень С-реактивного білка 1,68, 1,49; 1,95) тяжкий перебіг COVID-19, вимагав госпіталізації 5,7, 3,73; 7,89), незалежними предикторами смертності. У той же час, цільові рівні 0,87, 0,66; 0,99) Kt/V 0,74, 0,68; 0,96), а також вакцинація проти 0,17, 0,05; 0,61) статистично значущо знижували імовірність смерті. Наявність не впливала виживаність протягом років. Висновки. Дворічна визначається комбінацією демографічних клініко-лабораторних факторів, таких як вік, тривале ГД, коморбідна патологія, білково-енергетична недостатність, доступ, неадекватна діалізна доза, низькй гемоглобіну, хронічне запалення, недосягнення цільового рівня артеріального тиску, негативний вакцинальний гострого періоду необхідністю кисневої підтримки. Вакцинація підтримання цільових рівнів показників моніторингу після мають вирішальне значення для покращення виживання цієї категорії хворих.
Citations
0
Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14
Published: Nov. 14, 2024
Introduction The aim of this study was to compare the detection performance mNGS against that conventional tests (CT) in patients suffering from infection after kidney transplantation. Methods A total 138 samples 85 transplant with acute or chronic infections were simultaneously analyzed using and CT July 2021 August 2023. Results Compared CT, demonstrated a higher sensitivity (95.96% vs. 27.27%) but lower specificity (48.72% 84.62%) pathogen detection. Moreover, exhibited significant advantages detecting mixed rare infections. pathogens commonly identified severe respiratory syndrome coronavirus 2 (SARS-CoV-2), followed by Pneumocystis jirovecii Cytomegalovirus (CMV). guided precise clinical diagnosis 89.13% cases assisted altering therapeutics empirical antibiotic approaches personalized plans 56.10% cases, including treatment escalation (40.65%), initiation (11.38%), drug adjustment (3.25%), de-escalation (0.81%). Discussion Our superior its value. This reflected great potential as complementary technology for patients.
Language: Английский
Citations
0
Pediatru ro, Journal Year: 2024, Volume and Issue: 3(75), P. 22 - 22
Published: Jan. 1, 2024
Citations
0