Natural Polymer‐Based Hydrogels with Enhanced Mechanical Performances: Preparation, Structure, and Property

Advanced Healthcare Materials, Journal Year: 2019, Volume and Issue: 8(17)

Published: July 31, 2019

Abstract Hydrogels based on natural polymers have bright application prospects in biomedical fields due to their outstanding biocompatibility and biodegradability. However, the poor mechanical performances of pure polymer‐based hydrogels greatly limit prospects. Recently, a variety strategies has been applied prepare with enhanced properties, which generally exhibit stiffening, strengthening, stretchable behaviors. This article summarizes recent progress properties. From structure point view, four kinds hydrogel are reviewed; double network hydrogels, nanocomposite click chemistry‐based supramolecular hydrogels. For each typical hydrogel, its preparation, structure, performance introduced detail. At end this article, current challenges future discussed it is pointed out that 3D printing may offer new platform for development

Language: Английский

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Overcoming barriers by local drug delivery with liposomes

Advanced Drug Delivery Reviews, Journal Year: 2021, Volume and Issue: 174, P. 53 - 86

Published: Feb. 3, 2021

Language: Английский

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Rapid Fabrication of Self‐Healing, Conductive, and Injectable Gel as Dressings for Healing Wounds in Stretchable Parts of the Body

Advanced Functional Materials, Journal Year: 2020, Volume and Issue: 30(31)

Published: June 18, 2020

Abstract Skin wounds on stretchable parts of the body including elbows, knees, wrists, and nape usually undergo delayed poor healing due to interference their frequent motion. Ordinary dressings that are not flexible enough face difficulty promote wound mismatching between mechanics dressing materials wounds. In this study, an injectable, biocompatible, self‐healable, conductive material poly(3,4‐ethylenedioxythiophene): poly(styrenesulfonate)/guar slime (PPGS) is developed for with various kinds movements. As a proof‐of‐principle assay, effect PPGS explored skin model rats often experiences PPGS, which can be prepared within 1 min, successfully accelerates The results suggest has great potential in fields tissue engineering biomedicine.

Language: Английский

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The emerging role of nanotechnology in skincare

Advances in Colloid and Interface Science, Journal Year: 2021, Volume and Issue: 293, P. 102437 - 102437

Published: May 11, 2021

The role of cosmetic products is rapidly evolving in our society, with their use increasingly seen as an essential contribution to personal wellness. This suggests the necessity a detailed elucidation nanoparticles (NPs) cosmetics. aim present work offer critical and comprehensive review discussing impact exploiting nanomaterials advanced formulations, emphasizing beneficial effects extensive next-generation despite persisting prejudice around application nanotechnology discussion here includes interpretation data underlying generic information reported on product labels formulations already available marketplace, that often lacks details identifying specific components product, especially when are employed. emphasis this mainly focused skincare because it believed be cosmetics market sector which being most significantly. To date, has been demonstrated improve performance number different ways: 1) increasing both entrapment efficiency dermal penetration active ingredient, 2) controlling drug release, 3) enhancing physical stability, 4) improving moisturizing power, 5) providing better UV protection. Specific attention paid effect contained semisolid skin issues. In light emerging concerns about nanoparticle toxicity, entire section devoted listing examples nanocosmetic for safety investigated.

Language: Английский

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Nanoparticles for topical drug delivery: Potential for skin cancer treatment

Advanced Drug Delivery Reviews, Journal Year: 2020, Volume and Issue: 153, P. 87 - 108

Published: Jan. 1, 2020

Language: Английский

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Recent Advancements in Non-Invasive Formulations for Protein Drug Delivery

Computational and Structural Biotechnology Journal, Journal Year: 2019, Volume and Issue: 17, P. 1290 - 1308

Published: Jan. 1, 2019

Advancements in biotechnology and protein engineering expand the availability of various therapeutic proteins including vaccines, antibodies, hormones, growth factors. In addition, drugs hold many advantages over small synthetic terms high specificity activity. This has led to further R&D investment protein-based drug products an increased number approvals for proteins. However, there are biological biopharmaceutical obstacles inherent physicochemical enzymatic destabilization, which limit their development clinical application. Therefore, effective formulations needed overcome barriers. current medical practice, predominantly available injectable formulations, have disadvantages pain, possibility infection, cost, low patient compliance. Consequently, non-invasive delivery systems gained great attention research biomedicines. this review covers formulation approaches optimizing properties with emphasis on improving bioavailability It provides a comprehensive update recent advancements nanotechnologies regard systems, is also categorized by route administrations oral, nasal, transdermal, pulmonary, ocular, rectal systems.

Language: Английский

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Ethosomes as Nanocarriers for the Development of Skin Delivery Formulations

Pharmaceutical Research, Journal Year: 2021, Volume and Issue: 38(6), P. 947 - 970

Published: May 25, 2021

Language: Английский

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Challenges and Future Trends in the Treatment of Psoriasis

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(17), P. 13313 - 13313

Published: Aug. 28, 2023

Psoriasis is a chronic inflammatory skin disorder, and current treatments include topical therapies, phototherapy, systemic immune modulators, biologics, aiming to alleviate symptoms improve quality of life. However, challenges persist, such as adverse effects, treatment resistance, high costs, variability in response among individuals. The future psoriasis shows promising emerging trends. New biologic agents targeting novel pathways, interleukin 23 inhibitors like mirikizumab, offer enhanced efficacy. Small molecule RORγt ROCK2 provide additional options. Combination including biologics with methotrexate, may response. Advancements utilizing microneedles nanoparticle-based carriers can enhance drug delivery therapeutic outcomes. Biomarkers multi-omics technologies hold potential for personalized approaches, thus aiding diagnosis, predicting response, guiding decisions. Collaboration researchers, clinicians, industry stakeholders crucial translating these scientific breakthroughs into clinical practice. By addressing exploring trends, we optimize management the lives those affected by this condition.

Language: Английский

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Advances in the human skin microbiota and its roles in cutaneous diseases

Microbial Cell Factories, Journal Year: 2022, Volume and Issue: 21(1)

Published: Aug. 29, 2022

Skin is the largest organ in human body, and interplay between environment factors skin leads to some diseases, such as acne, psoriasis, atopic dermatitis. As first line of immune defense, plays significant roles health via preventing invasion pathogens that heavily influenced by microbiota. Despite being a challenging niche for microbes, colonized diverse commensal microorganisms shape environment. The microbiota can affect health, its imbalance dysbiosis contribute diseases. This review focuses on advances our understanding interaction with skin. Moreover, potential diseases are described, key species highlighted. prevention, diagnosis treatment strategies microbe-related healthy diets, lifestyles, probiotics prebiotics, discussed. Strategies modulation using synthetic biology discussed an interesting venue optimization skin-microbiota interactions. In summary, this provides insights into recovery, interactions engineering/rebuilding

Language: Английский

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Current Advances in Lipid Nanosystems Intended for Topical and Transdermal Drug Delivery Applications

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(2), P. 656 - 656

Published: Feb. 15, 2023

Skin delivery is an exciting and challenging field. It a promising approach for effective drug due to its ease of administration, handling, high flexibility, controlled release, prolonged therapeutic effect, adaptability, many other advantages. The main associated challenge, however, low skin permeability. healthy barrier that serves as the body's primary defence mechanism against foreign particles. New advances in (both topical transdermal) depend on overcoming challenges with molecule permeation irritation. These limitations can be overcome by employing new approaches such lipid nanosystems. Due their advantages (such easy scaling, cost, remarkable stability) these systems have attracted interest from scientific community. However, successful formulation, several factors including particle size, surface charge, components, etc. understood controlled. This review provided brief overview structure well different pathways nanoparticle penetration. In addition, influencing penetration nanoparticles been highlighted. Applications nanosystems dermal transdermal delivery, regulatory aspects, were critically discussed.

Language: Английский

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