Lipid-Based Nanoparticles for Drug/Gene Delivery: An Overview of the Production Techniques and Difficulties Encountered in Their Industrial Development DOI Creative Commons
Meenu Mehta, Thuỳ Anh Bùi,

Xinpu Yang

et al.

ACS Materials Au, Journal Year: 2023, Volume and Issue: 3(6), P. 600 - 619

Published: Aug. 21, 2023

Over the past decade, therapeutic potential of nanomaterials as novel drug delivery systems complementing conventional pharmacology has been widely acknowledged. Among these nanomaterials, lipid-based nanoparticles (LNPs) have shown remarkable pharmacological performance and promising outcomes, thus gaining substantial interest in preclinical clinical research. In this review, we introduce main types LNPs used formulations such liposomes, nanoemulsions, solid lipid nanoparticles, nanostructured carriers, polymer hybrid focusing on their physicochemical properties potential. We discuss computational studies modeling techniques to enhance understanding how interact with cargo predict effectiveness interactions applications. also analyze benefits drawbacks various LNP production nanoprecipitation, emulsification, evaporation, thin film hydration, microfluidic-based methods, an impingement jet mixer. Additionally, major challenges associated industrial development, including stability sterilization, storage, regulatory compliance, reproducibility, quality control. Overcoming facilitating compliance represent key steps toward LNP's successful commercialization translation into settings.

Language: Английский

Lipid Nanoparticles─From Liposomes to mRNA Vaccine Delivery, a Landscape of Research Diversity and Advancement DOI Creative Commons

Rumiana Tenchov,

Robert E. Bird,

Allison Curtze

et al.

ACS Nano, Journal Year: 2021, Volume and Issue: 15(11), P. 16982 - 17015

Published: June 28, 2021

Lipid nanoparticles (LNPs) have emerged across the pharmaceutical industry as promising vehicles to deliver a variety of therapeutics. Currently in spotlight vital components COVID-19 mRNA vaccines, LNPs play key role effectively protecting and transporting cells. Liposomes, an early version LNPs, are versatile nanomedicine delivery platform. A number liposomal drugs been approved applied medical practice. Subsequent generations lipid nanocarriers, such solid nanoparticles, nanostructured carriers, cationic lipid–nucleic acid complexes, exhibit more complex architectures enhanced physical stabilities. With their ability encapsulate therapeutics specific locations within body release contents at desired time, provide valuable platform for treatment diseases. Here, we present landscape LNP-related scientific publications, including patents journal articles, based on analysis CAS Content Collection, largest human-curated collection published knowledge. Rising trends identified, carriers becoming preferred platforms numerous formulations. Recent advancements LNP formulations drug platforms, antitumor nucleic vaccine systems, discussed. Challenges growth opportunities also evaluated other areas, imaging, cosmetics, nutrition, agrochemicals. This report is intended serve useful resource those interested nanotechnologies, applications, global research effort development.

Language: Английский

Citations

1364
The role of lipid components in lipid nanoparticles for vaccines and gene therapy DOI

Camilla Hald Albertsen,

Jayesh A. Kulkarni, Dominik Witzigmann

et al.

Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 188, P. 114416 - 114416

Published: July 3, 2022

Language: Английский

Citations

588
mRNA-based therapeutics: powerful and versatile tools to combat diseases DOI Creative Commons
Shugang Qin,

Xiaoshan Tang,

Yu‐Ting Chen

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: May 21, 2022

Abstract The therapeutic use of messenger RNA (mRNA) has fueled great hope to combat a wide range incurable diseases. Recent rapid advances in biotechnology and molecular medicine have enabled the production almost any functional protein/peptide human body by introducing mRNA as vaccine or agent. This represents rising precision field with promise for preventing treating many intractable genetic In addition, vitro transcribed achieved programmed production, which is more effective, faster design well flexible cost-effective than conventional approaches that may offer. Based on these extraordinary advantages, vaccines characteristics swiftest response large-scale outbreaks infectious diseases, such currently devastating pandemic COVID-19. It always been scientists’ desire improve stability, immunogenicity, translation efficiency, delivery system achieve efficient safe mRNA. Excitingly, scientific dreams gradually realized rapid, amazing achievements biology, technology, vaccinology, nanotechnology. this review, we comprehensively describe mRNA-based therapeutics, including their principles, manufacture, application, effects, shortcomings. We also highlight importance optimization systems successful therapeutics discuss key challenges opportunities developing tools into powerful versatile genetic, infectious, cancer, other refractory

Language: Английский

Citations

426
Advances in COVID-19 mRNA vaccine development DOI Creative Commons
Enyue Fang, Xiaohui Liu, Miao Li

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: March 23, 2022

Abstract To date, the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome 2 (SARS-CoV-2) has determined 399,600,607 cases and 5,757,562 deaths worldwide. COVID-19 is a serious threat to human health globally. The World Health Organization (WHO) declared pandemic major public emergency. Vaccination most effective economical intervention for controlling spread of epidemics, consequently saving lives protecting population. Various techniques have been employed in development vaccines. Among these, messenger RNA (mRNA) vaccine drawing increasing attention owing its great application prospects advantages, which include short cycle, easy industrialization, simple production process, flexibility respond new variants, capacity induce better immune response. This review summarizes current knowledge on structural characteristics, antigen design strategies, delivery systems, industrialization potential, quality control, latest clinical trials real-world data mRNA vaccines as well technology. Current challenges future directions preventive infectious diseases are also discussed.

Language: Английский

Citations

414
Lipids and Lipid Derivatives for RNA Delivery DOI
Yuebao Zhang, Changzhen Sun, Chang Wang

et al.

Chemical Reviews, Journal Year: 2021, Volume and Issue: 121(20), P. 12181 - 12277

Published: July 19, 2021

RNA-based therapeutics have shown great promise in treating a broad spectrum of diseases through various mechanisms including knockdown pathological genes, expression therapeutic proteins, and programmed gene editing. Due to the inherent instability negative-charges RNA molecules, can make most use delivery systems overcome biological barriers release payload into cytosol. Among different types systems, lipid-based particularly lipid nanoparticles (LNPs), been extensively studied due their unique properties, such as simple chemical synthesis components, scalable manufacturing processes LNPs, wide packaging capability. LNPs represent widely used for therapeutics, evidenced by clinical approvals three LNP-RNA formulations, patisiran, BNT162b2, mRNA-1273. This review covers recent advances lipids, derivatives, lipid-derived macromolecules over past several decades. We focus mainly on structures, synthetic routes, characterization, formulation methods, structure–activity relationships. also briefly describe current status representative preclinical studies trials highlight future opportunities challenges.

Language: Английский

Citations

403
Lipid Nanoparticles for Drug Delivery DOI Creative Commons
Letao Xu, Xing Wang, Yun Liu

et al.

Advanced NanoBiomed Research, Journal Year: 2021, Volume and Issue: 2(2)

Published: Nov. 25, 2021

Lipid nanoparticles have attracted significant interests in the last two decades, and achieved tremendous clinical success since first approval of Doxil 1995. At same time, lipid also demonstrated enormous potential delivering nucleic acid drugs as evidenced by RNA therapies mRNA COVID‐19 vaccines. In this review, an overview on different classes nanoparticles, including liposomes, solid nanostructured carriers, is provided, followed introduction their preparation methods. Then characterizations are briefly reviewed applications encapsulating hydrophobic drugs, hydrophilic RNAs highlighted. Finally, various for overcoming delivery challenges, crossing blood–brain barrier, targeted delivery, routes administration, summarized. drug systems offer many attractive benefits such great biocompatibility, ease preparation, feasibility scale‐up, nontoxicity, while current challenges warrant future studies about structure–function correlations, large‐scale production, to realize full wider pharmaceutical future.

Language: Английский

Citations

313
The protein corona from nanomedicine to environmental science DOI Open Access
Morteza Mahmoudi, Markita P. Landry, Anna Moore

et al.

Nature Reviews Materials, Journal Year: 2023, Volume and Issue: 8(7), P. 422 - 438

Published: March 24, 2023

Language: Английский

Citations

298
Therapeutic in vivo delivery of gene editing agents DOI Creative Commons
Aditya Raguram, Samagya Banskota, David R. Liu

et al.

Cell, Journal Year: 2022, Volume and Issue: 185(15), P. 2806 - 2827

Published: July 1, 2022

In vivo gene editing therapies offer the potential to treat root causes of many genetic diseases. Realizing promise therapeutic in requires ability safely and efficiently deliver agents relevant organs tissues vivo. Here, we review current delivery technologies that have been used enable editing, including viral vectors, lipid nanoparticles, virus-like particles. Since no single modality is likely be appropriate for every possible application, compare benefits drawbacks each method highlight opportunities future improvements.

Language: Английский

Citations

294
Evolution of drug delivery systems: From 1950 to 2020 and beyond DOI
Haesun Park, Andrew Otte, Kinam Park

et al.

Journal of Controlled Release, Journal Year: 2021, Volume and Issue: 342, P. 53 - 65

Published: Dec. 28, 2021

Language: Английский

Citations

287
Engineering mesoporous silica nanoparticles for drug delivery: where are we after two decades? DOI Creative Commons
Maria Vallet‐Regí, Ferdi Schüth, Daniel Lozano

et al.

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(13), P. 5365 - 5451

Published: Jan. 1, 2022

The present review details a chronological description of the events that took place during development mesoporous materials, their different synthetic routes and use as drug delivery systems. outstanding textural properties these materials quickly inspired translation to nanoscale dimension leading silica nanoparticles (MSNs). aspects introducing pharmaceutical agents into pores nanocarriers, together with possible biodistribution clearance routes, would be described here. smart nanocarriers are able release high local concentration therapeutic cargo on-demand after application certain stimuli reviewed here, ability deliver precise locations in body. huge progress design MSNs for biomedical applications, including potential treatment diseases, last 20 years will collated required work still needs done achieve clinical materials. This was conceived stand out from past reports since it aims tell story systems by some makers, who could considered among pioneers this area.

Language: Английский

Citations

279