Recent advances in nanoparticle-based photothermal therapy for breast cancer

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 349, P. 269 - 303

Published: July 9, 2022

Language: Английский

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CD44-Targeted Nanocarrier for Cancer Therapy

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 12

Published: March 31, 2022

Cluster of differentiation 44 (CD44) is a cell surface glycoprotein overexpressed in varieties solid tumors including pancreatic, breast, ovary, brain, and lung cancers. It multi-structural the which majorly involved proliferation, cell-to-cell interaction, cellular migration, inflammation, generation immune responses. Numerous studies focus on development nanocarriers for active targeting CD44 receptor to improve efficacy chemotherapy achieve precise by defining release, uptake, accumulation therapeutic agents. The has selective binding affinity towards hyaluronic chondroitin sulfate (CS). Taking this into consideration, review focused role cancer its therapy using several such as polymeric/non-polymeric nanoparticles, dendrimer, micelles, carbon nanotubes, nanogels, nanoemulsions etc., targeted delivery chemotherapeutic molecules nucleic acid. This also illuminates acid (HA) therapy, interaction HA with CD44, various approaches target CD44-overexpressed neoplastic cells.

Language: Английский

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Photothermal conversion and transfer in photothermal therapy: From macroscale to nanoscale

Advances in Colloid and Interface Science, Journal Year: 2022, Volume and Issue: 308, P. 102753 - 102753

Published: Aug. 16, 2022

Photothermal therapy (PTT) is a promising alternative for benign or even malignant tumors. To improve the selective heating of tumor cells, target-specific photothermal conversion agents are often included, especially nanoparticles. Meanwhile, some indirect methods by manipulating radiation and heat delivery also adopted. Therefore, to gain clear understanding mechanism, controllability PTT, few issues need be clarified, including bioheat transfer, localized collective nanoparticles, etc. In this review, we provide an introduction typical transfer models along with dynamic thermophysical properties biological tissue. On basis, reviewed most recent advances in temperature control PTT from macroscale nanoscale. Most importantly, comprehensive effects nanoparticle clusters provided give insight into mechanism PPT microscale nanoscale point view.

Language: Английский

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Near-infrared photodynamic and photothermal co-therapy based on organic small molecular dyes

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: Sept. 27, 2023

Abstract Near-infrared (NIR) organic small molecule dyes (OSMDs) are effective photothermal agents for therapy (PTT) due to their advantages of low cost and toxicity, good biodegradation, strong NIR absorption over a wide wavelength range. Nevertheless, OSMDs have limited applicability in PTT conversion efficiency inadequate destruction tumor regions that nonirradiated by light. However, they can also act as photosensitizers (PSs) produce reactive oxygen species (ROS), which be further eradicated using ROS-related therapies address the above limitations PTT. In this review, synergistic mechanism, composition, properties photodynamic (PDT)–PTT nanoplatforms were comprehensively discussed. addition, some specific strategies improving combined PDT based on cancer completely eradicate cells outlined. These include performing image-guided co-therapy, enhancing infiltration, increasing H 2 O or microenvironment, loading anticancer drugs onto enable with phototherapy chemotherapy. Meanwhile, intriguing prospects challenges treatment modality summarized focus future trends its clinical application. Graphical

Language: Английский

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Design of One-for-All Near-Infrared Aggregation-Induced Emission Nanoaggregates for Boosting Theranostic Efficacy

ACS Nano, Journal Year: 2023, Volume and Issue: 17(5), P. 4591 - 4600

Published: March 1, 2023

Fluorescence-guided phototherapy, including photodynamic and photothermal therapy, is considered an emerging noninvasive strategy for cancer treatments. Organic molecules are promising theranostic agents because of their facile construction, simple modification, good biocompatibility. systems that integrated multifunctionalities in a single component achieved high efficiency both imaging therapies rarely reported as the inherently competitive energy relaxation pathways hard to modulate, fluorescence quenching occurs upon molecular aggregation. Herein, versatile platform with near-infrared emission, quantum yield, robust reactive oxygen species production, excellent conversion was developed based on aggregation-induced emission luminogen, namely, TPA-TBT. In vivo studies revealed TPA-TBT nanoaggregates exhibit outstanding therapy efficacy ablate tumors inoculated mouse model. This work offers design develop one-for-all by modulating utilizing excitons full.

Language: Английский

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Recent Advances and Clinical Potential of Near Infrared Photothermal Conversion Materials for Photothermal Hepatocellular Carcinoma Therapy

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(29)

Published: June 9, 2023

Abstract Growing concern about photothermal tumor therapy (PTT) as a promising alternative to conventional liver cancer treatment, which is treatment strategy that utilizes near‐infrared (NIR) light‐induced agents (PTAs) yield effects localize thermal damage for tumors. Herein, given the gap between experimental research and clinical application, this review seeks timely summarize highlight recent progress of PTAs used in vivo vitro last five‐year. The implications various on multifunctional conversion capability, structure‐performance correlations PTT, together with evaluation their potential application are systematically dissected further dig out what buried mechanism is. Besides, higher requirements put forward discrepancies crucial issues faced by different PTT related medical technical obstacles being conquered, lays solid theoretical foundation field oncology whole, especially cancer. Finally, it expected can present valuable guidance design efficient, photostability, biosafety‐aware anticancer while stepping into fast traffic lane from bench bedside foreseeable future.

Language: Английский

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Gold nanoparticles-mediated photothermal and photodynamic therapies for cancer

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 655, P. 124057 - 124057

Published: March 27, 2024

Language: Английский

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Advanced nanomedicine approaches applied for treatment of skin carcinoma

Journal of Controlled Release, Journal Year: 2021, Volume and Issue: 337, P. 589 - 611

Published: Aug. 6, 2021

Language: Английский

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Gold Nanorod-Assisted Photothermal Therapy and Improvement Strategies

Bioengineering, Journal Year: 2022, Volume and Issue: 9(5), P. 200 - 200

Published: May 5, 2022

Noble metal nanoparticles have been sought after in cancer nanomedicine during the past two decades, owing to unique localized surface plasmon resonance that induces strong absorption and scattering properties of nanoparticles. A popular application noble is photothermal therapy, which destroys cells by heat generated laser irradiation Gold nanorods stood out as one major types for therapy due facile tuning their optical tissue penetrative near infrared region, conversion efficiency, long blood circulation half-life modification with stealthy polymers. In this review, we will summarize gold applications therapy. We also discuss recent strategies improve nanorod-assisted through combination chemotherapy photodynamic

Language: Английский

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Liposome-based diagnostic and therapeutic applications for pancreatic cancer

Acta Biomaterialia, Journal Year: 2022, Volume and Issue: 157, P. 1 - 23

Published: Dec. 12, 2022

Pancreatic cancer is one of the harshest and most challenging cancers to treat, often labeled as incurable. Chemotherapy continues be popular treatment yet yields a very poor prognosis. The main barriers such inefficient drug penetration resistance, have led development carrier systems. benefits, ease fabrication modification liposomes render them ideal future delivery This review delves into versatility achieve various mechanisms for pancreatic cancer. Not only are there benefits loading chemotherapy drugs targeting agents onto liposomes, well mRNA combined therapy, but also been exploited immunotherapy can programmed respond photothermal therapy. Multifunctional liposomal formulations demonstrated significant pre-clinical success. Functionalising drug-encapsulated has resulted in triggered release, specific targeting, remodeling tumor environment. Suppressing progression achieved, due their ability more efficiently precisely deliver chemotherapy. Currently, no multifunctional surface-modified clinically approved thus we aim shed light on trials tribulations progress so far, with hope therapy improved patient outcomes. STATEMENT OF SIGNIFICANCE: Considering that conventional treatments highly associated sub-optimal performance systemic toxicity, novel therapeutic strategies holds outmost relevance management. Liposomes being increasingly considered promising nanocarriers providing not an early diagnosis effective, specific, safer treatment, improving overall outcome. manuscript first last 10 years revises advances application liposome-based bioimaging, chemotherapy, phototherapy, immunotherapy, combination therapies, emergent therapies Prospective insights provided regarding several advantages resulting from use liposome technology precision strategies, fostering new ideas next-generation targeted

Language: Английский

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