J‐Aggregation Strategy toward Potentiated NIR‐II Fluorescence Bioimaging of Molecular Fluorophores

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(1)

Published: Aug. 1, 2023

Molecular fluorophores emitting in the second near-infrared (NIR-II, 1000-1700 nm) window with strong optical harvesting and high quantum yields hold great potential for vivo deep-tissue bioimaging high-resolution biosensing. Recently, J-aggregates are harnessed to engineer long-wavelength NIR-II emitters show unique superiority tumor detection, vessel mapping, surgical navigation, phototheranostics due their bathochromic-shifted bands required slip-stacked arrangement aggregation state. However, despite preliminary progress of theoretical study structure-property relationships, further paradigms remain scarce lack on aggregated fashion. In this effort, how utilize specific molecular structure form packing motifs J-type exciton coupling is emphatically elucidated. First, several regulating strategies achieve containing intermolecular interactions external conditions positively summarized deeply analyzed. Then, recent reports theranostics systematically provide a clear reference direction promoting development organic fluorophores. Eventually, prospective efforts ameliorating clinical practices outlined.

Language: Английский

---

Bioinspired AIE Nanomedicine: A Burgeoning Technology for Fluorescence Bioimaging and Phototheranostics

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(32)

Published: June 14, 2024

Abstract Nanomedicine on the basis of aggregated‐induced emission (AIE) luminogens with exceptional potency is growing into a sparkling frontier in fluorescence imaging and phototheranostics. Of particular interest biomimetic AIE nanomedicine comprised by biocarrier, which represents win–win integration are recently developed at tremendous pace, mainly benefiting from intrinsic advantages including enhanced biocompatibility, prolonged circulation time, specific targeting ability, immune activation, supremely extraordinary phototheranostic outputs. In view inexhaustible vigorous vitality field, this review provides an integrated picture involving basic concepts, significant breakthroughs, recent trends. addition, based current achievements, some critical challenges perspectives also discussed.

Language: Английский

---

Near‐infrared aggregation‐induced emission materials: Bibliometric analysis and their application in biomedical field

Aggregate, Journal Year: 2024, Volume and Issue: 5(3)

Published: Jan. 31, 2024

Abstract Aggregation‐induced emission (AIE) is an intriguing photophysical phenomenon, where specific materials exhibit a remarkable surge in luminescence when brought together non‐ideal solvents or within solid matrix. Since the concept of AIE was first introduced 2001, numerous advanced applications have been gradually explored across various domains, including optics, electronics, energy, and life sciences. Of particular note growing interest application systems with near‐infrared (NIR) emissive feature field biomedicine, encompassing detection, imaging, therapeutic interventions. Notably, bibliometric analysis serves as valuable tool to provide researchers comprehensive understanding research achievements developmental trends fields, which crucial for academic research. Herein, we present general overview spanning two decades NIR‐AIE development. With assistance core scientific databases software tools, conducted systematic annual publications citations, most influential countries/regions, leading authors, journals, institutions, well hot topics related NIR forward‐looking predictions. Furthermore, properties biomedical also systematically reviewed.

Language: Английский

---

Ultrabright NIR AIEgen nanoparticles‐enhanced lateral flow immunoassay platform for accurate diagnostics of complex samples

Aggregate, Journal Year: 2024, Volume and Issue: unknown

Published: April 10, 2024

Abstract Accurate and sensitive near‐infrared (NIR) luminescent lateral flow immunoassay (LFIA) has attracted considerable attention in the field of point‐of‐care testing (POCT). However, detection accuracy sensitivity are often compromised by low fluorescence quantum efficiency (<10%) NIR fluorescent probe. Herein, ultrabright AIEgen nanoparticles (PS@AIE 830 NPs) composed polystyrene (PS) aggregation‐induced emission luminogen (AIEgen) with maximum at nm (AIE ) is reported, its potential to promote an accurate complex samples LFIA described. The relative yield (QY) PS@AIE NPs was 14.76%, which superior that polymer embedding method indocyanine green (ICG)‐based nanoparticles. immunolabeled‐LFIA combined laboratory‐built NIR‐LFIA portable quantitative instruments (detected light range > 800 nm) completely eliminated background interference allowed highly without any pre‐treatment steps. limits (LODs) for aflatoxin B 1 (AFB soy sauce, alpha hemolysin (Hla) Staphylococcus aureus biomarker joint fluid, C‐reactive protein (CRP) human haemolysed were 0.01 ng mL −1 , 0.02 µg 0.156 mg L respectively, commensurating those corresponding gold standard assays covering interests. It anticipated will serve as a universally applicable signal probe diagnostics, promising expand applications samples.

Language: Английский

---

Recent Advances in Strategies to Enhance Photodynamic and Photothermal Therapy Performance of Single‐Component Organic Phototherapeutic Agents

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract Photodynamic therapy (PDT) and photothermal (PTT) have emerged as promising treatment options, showcasing immense potential in addressing both oncologic nononcologic diseases. Single‐component organic phototherapeutic agents (SCOPAs) offer advantages compared to inorganic or multicomponent nanomedicine, including better biosafety, lower toxicity, simpler synthesis, enhanced reproducibility. Nonetheless, how further improve the therapeutic effectiveness of SCOPAs remains a challenging research area. This review delves deeply into strategies performance PDT PTT by optimizing structural design SCOPAs. These encompass augmenting reactive oxygen species (ROS) generation, mitigating dependence, elevating light absorption capacity, broadening region, enhancing conversion efficiency (PCE). Additionally, this also underscores ideal for developing with balanced PTT. Furthermore, synergies are highlighted between other modalities such ferroptosis, gas therapy, chemotherapy, immunotherapy. By providing comprehensive analysis these strategies, aspires serve valuable resource clinicians researchers, facilitating wider application advancement SCOPAs‐mediated

Language: Английский

---

A Highly Water‐Soluble Aggregation‐Induced Emission Luminogen with Anion‐π⁺ Interactions for Targeted NIR Imaging of Cancer Cells and Type I Photodynamic Therapy

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(33)

Published: June 26, 2023

The low oxygen dependence of type I photosensitizers (PSs) has made them a popular choice for treating solid tumors. However, the drawbacks poor water solubility, short emission wavelength, stability, and inability to distinguish cancer cells from normal limit application most PSs in clinical therapy. Thereby, developing novel overcoming these problems is an urgent but challenging task. Herein, by utilizing distinctive structural characteristics anion-π+ interactions, highly water-soluble PS (DPBC-Br) with aggregation-induced (AIE) characteristic near-infrared (NIR) fabricated first time. DPBC-Br displays remarkable solubility (7.3 mM) outstanding photobleaching resistance, enabling efficient precise differentiation between tumor wash-free long-term tracking manner via NIR-I imaging. Additionally, superior reactive species (ROS) produced provide both specific killing vitro inhibition growth vivo, negligible systemic toxicity. This study rationally constructs PS, which higher reliability controllability compared conventional nanoparticle formulating procedures, offering great potential treatment.

Language: Английский

---

Ultrasound-Chargeable Persistent Luminescence Nanoparticles to Generate Self-Propelled Motion and Photothermal/NO Therapy for Synergistic Tumor Treatment

ACS Nano, Journal Year: 2023, Volume and Issue: 17(16), P. 16089 - 16106

Published: July 29, 2023

Cancer phototherapy indicates advantages in ease of manipulation, negligible drug resistance, and spatiotemporal control but is confronted with challenges tumor cell accessibility intermittent light excitation. Herein, we propose a strategy persistent luminescence (PL)-excited photothermal therapy (PTT), concurrent thermophoresis-propelled motion, PL-triggered NO release, where PL emission chargeable by ultrasonication for readily applicable to deep tumors. Mechanoluminescent (ML) nanodots SrAl2O4:Eu2+ (SAOE) ZnGa2O4:Cr3+ (ZGC) were deposited on mesoporous silicates obtain mSZ nanoparticles (NPs), followed partially coating polydopamine (PDA) caps loading donors prepare Janus mSZ@PDA-NO NPs. The ML bands SAOE overlap the excitation band ZGC, near-infrared (NIR) could be repeatedly activated ultrasonication. acts as an internal NIR source produce thermophoretic force gas propellers drive motion Compared commonly used illumination at both 660 808 nm, ultrasound-activated NPs enhances cellular uptake long-lasting PTT intracellular levels combat cells without use any chemotherapeutic drugs. promotes intratumoral accumulation distribution PTT/NO therapeutics exhibits significantly higher growth inhibition, longer animal survival, larger than those who experience external illumination. Thus, this study demonstrates activate emissions construct PL-excited nanomotors tissues.

Language: Английский

---

pH-Responsive Upconversion Mesoporous Silica Nanospheres for Combined Multimodal Diagnostic Imaging and Targeted Photodynamic and Photothermal Cancer Therapy

ACS Nano, Journal Year: 2023, Volume and Issue: 17(19), P. 18979 - 18999

Published: Sept. 13, 2023

Photodynamic therapy (PDT) and photothermal (PTT) have gained considerable attention as potential alternatives to conventional cancer treatments. However, these approaches remain limited by low solubility, poor stability, inefficient targeting of many common photosensitizers (PSs) agents (PTAs). To overcome the aforementioned limitations, we engineered biocompatible biodegradable tumor-targeted upconversion nanospheres with imaging capabilities. The multifunctional consist a sodium yttrium fluoride core doped lanthanides (ytterbium, erbium, gadolinium) PTA bismuth selenide (NaYF4:Yb/Er/Gd,Bi2Se3) enveloped in mesoporous silica shell that encapsulates PS, chlorin e6 (Ce6), within its pores. NaYF4:Yb/Er converts deeply penetrating near-infrared (NIR) light visible light, which excites Ce6 generate cytotoxic reactive oxygen species (ROS), while Bi2Se3 efficiently absorbed NIR heat. Additionally, Gd enables magnetic resonance nanospheres. is coated DPPC/cholesterol/DSPE-PEG retain encapsulated prevent serum protein adsorption macrophage recognition hinder tumor targeting. Finally, coat conjugated acidity-triggered rational membrane (ATRAM) peptide, promotes specific efficient internalization into malignant cells mildly acidic microenvironment tumors. facilitated thermal fluorescence exhibited potent laser light-induced anticancer effects vitro vivo via combined ROS production localized hyperthermia, negligible toxicity healthy tissue, hence markedly extending survival. Our results demonstrate ATRAM-functionalized, lipid/PEG-coated (ALUMSNs) offer multimodal diagnostic targeted combinatorial therapy.

Language: Английский

---

Approaching Microsized Alloy Anodes via Solid Electrolyte Interphase Design for Advanced Rechargeable Batteries

Advanced Energy Materials, Journal Year: 2023, Volume and Issue: 13(23)

Published: May 1, 2023

Abstract Microsized alloy anodes (Si, P, Sb, Sn, Bi, etc.) with high capacity, proper working potential, tap density, and low cost are promising for breaking the energy limits of current rechargeable batteries. Nevertheless, they suffer from large volume changes during cycling processes, posing a great challenge in maintaining thin, dense, intact solid electrolyte interphase (SEI) layer. Recent progress suggests that problematic SEI layer can be turned to advantage integrity microparticle if well designed, which is expected significantly boost cyclic stability without resorting complex electrode architectures. Advances this attractive direction reviewed shed light on future development. First, key issues high‐capacity microsized fundamentals discussed. Thereafter, regulation strategies layers advanced batteries, including engineering, surface modification, cycle protocols, architecture design, outlined. Finally, potential challenges perspectives developing high‐quality proposed.

Language: Английский

---

Ultrabright NIR-II Nanoprobe for Image-Guided Accurate Resection of Tiny Metastatic Lesions

Nano Letters, Journal Year: 2024, Volume and Issue: 24(4), P. 1367 - 1375

Published: Jan. 16, 2024

Fluorescence imaging is a vital way to delineate the tumor boundaries. Here, we achieve NIR-II aggregation-induced emission luminogen (AIEgen) with fluorescence quantum yield (QY) of 12.6% in water through straightforward alkyl side chain modification. After loading AIEgen into polystyrene (PS) nanospheres, thermal deactivation pathway extremely limited, thereby concentrating absorption excitation on emission. The intensity further enhanced by 5.4 times, QY increases 21.1%, and signal accordingly 8.7 surpassing conventional DSPE-PEG carriers. NIR-II@PS nanoprobe showcases superior resolution tissue penetration depth compared indocyanine green (ICG) short-range near-infrared AIEgens. In vivo investigations underscore its tumor-to-normal ratio (3.9) at 24 h post intravenous injection, enabling complete resection ≤1 mm metastases under bioimaging guidance. Additionally, PS carrier-nanoparticles exhibit low toxicity vivo, laying promising foundation for future design medical nanomaterials.

Language: Английский

---