International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 155 - 169
Published: Jan. 1, 2024
Background:
Targeted
delivery
systems
have
been
developed
to
improve
cancer
treatment
by
reducing
side
effects
and
enhancing
drug
efficacy.
Geraniol,
a
natural
product,
has
demonstrated
promising
anti-cancer
in
various
types,
including
prostate
cancer,
which
is
the
most
commonly
diagnosed
men.
Hyaluronic
acid
(HA),
carrier
targeting
CD44-positive
cells,
can
be
utilized
targeted
system.
Purpose:
This
study
investigated
efficacy
of
conjugate
HA
geraniol
linked
via
disulfide
bond
linker
(HA-SS-Geraniol)
cancer.
Materials
Methods:
The
cytotoxicity
HA-SS-Geraniol
was
evaluated
on
human
PC-3
cells.
Flow
cytometry
used
assess
its
mitochondrial
membrane
potential,
apoptosis,
cell
cycle
arrest.
Additionally,
proteomic
analysis
conducted
explore
underlying
mechanism
action
induced
treatment.
A
subcutaneous
xenograft
tumor
model
established
nude
mice
evaluate
toxicity
vivo.
Results:
results
that
exhibited
potent
against
cells
inducing
potential
loss
apoptosis
vitro.
further
supported
hypothesis
induces
death
through
mitochondria-mediated
as
evidenced
differential
protein
expression.
vivo
mouse
confirmed
safety
ability
inhibit
growth.
Conclusion:
holds
promise
biologically
safe
potentially
effective
therapeutic
agent
for
Its
system
utilizing
shows
improving
therapy.
Keywords:
geraniol,
hyaluronic
acid,
nanoparticle,
proteomics
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(1), P. 70 - 70
Published: Jan. 7, 2025
Malignant
growth
is
expected
to
surpass
other
significant
causes
of
death
as
one
the
top
reasons
for
dismalness
and
mortality
worldwide.
According
a
World
Health
Organization
(WHO)
study,
this
illness
approximately
between
9
10
million
instances
deaths
annually.
Chemotherapy,
radiation,
surgery
are
three
main
methods
treating
cancer.
These
seek
completely
eradicate
all
cancer
cells
while
having
fewest
possible
unintended
impacts
on
healthy
cell
types.
Owing
lack
target
selectivity,
majority
medications
have
substantial
side
effects.
On
hand,
nanomaterials
transformed
identification,
diagnosis,
management
Nanostructures
with
biomimetic
properties
been
grown
late,
fully
intent
observing
sickness.
nanostructures
be
consumed
by
in
areas
profound
disease.
Furthermore,
because
their
extraordinary
physicochemical
properties,
which
incorporate
nanoscale
aspects,
more
prominent
surface
region,
explicit
geometrical
features,
ability
embody
different
substances
within
or
outside
surfaces,
remarkable
nano-vehicles
conveying
restorative
specialists
designated
regions.
This
review
discusses
recent
developments
nanostructured
materials
such
graphene,
dendrimers,
cell-penetrating
peptide
nanoparticles,
nanoliposomes,
lipid
magnetic
nano-omics
diagnosis
Nucleosides Nucleotides & Nucleic Acids,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 25
Published: Jan. 13, 2025
The
field
of
biomedical
science
has
witnessed
another
milestone
with
the
advent
RNA-based
therapeutics.
This
review
explores
three
major
RNA
molecules,
namely:
messenger
(mRNA),
interference
technology
(RNAi),
and
Antisense
Oligonucleotide
(ASO),
analyses
U.S.
Food
Drug
Administration
drugs
from
14
pharmaceutical
companies
in
terms
targeted
genes,
diseases
types,
clinical
trials
status,
mode
delivery,
year
production.
Many
such
are
clinically
approved
or
pending
approval
by
(FDA)
alongside
other
leading
agencies.
Regarding
diseases,
this
article
emphasizes
cancer
therapy,
genetic
viral
infections,
two
categories
drug
delivery
systems
include
vectors
nanoparticles.
Despite
tremendous
progress
made,
key
issues
associated
these
stability,
off-target
activities
payloads,
efficiency
cellular
uptake,
innovative
need
for
engineering
techniques
modifications.
transformative
potential
therapeutics
role
technologies
addressing
needs,
paving
way
a
new
era
precision
medicine.
Frontiers in Pharmacology,
Journal Year:
2023,
Volume and Issue:
13
Published: Jan. 12, 2023
Cervical
carcinoma
is
one
of
the
most
prevalent
gynecological
cancers
throughout
world.
Cisplatin
used
as
first
line
chemotherapy
for
treatment
cervical
cancer,
but
it
comes
with
plethora
side
effects.
The
aim
this
study
was
to
develop
hyaluronic
acid
coated,
thiolated
chitosan
nanocarriers
using
green
synthesis
approach,
CD44
targeted
delivery
and
sustained
release
in
cancer
cells.
After
through
ionic
gelation
method,
Zeta
analysis
showed
that
nanoparticle
size
265.9
nm
a
zeta
potential
+22.3
mV
.226
PDI.
SEM
TEM
confirmed
spherical
shape
smooth
surface
nanoparticles.
FTIR
XRD
presence
characteristic
functional
groups,
successful
encapsulation
drug,
crystalline
nature
nanoparticles
respectively.
Drug
loading
entrapment
efficiency
were
calculated
be
70.1%
±
1.2%
45%
.28%
Analysis
vitro
drug
kinetics
followed
Higuchi
model
at
pH
6.8
7.4
up
72
h
release.
In
on
cells
HeLa
normal
epithelial
HCK1T
done
cell
morphology
analysis,
trypan
blue
assay
(concentration
range
10-80
μg/ml),
MTT
cytotoxic
10-90
μg/ml).
results
higher
HA
encapsulated
(HA-ThCs-Cis
NP)
nanoformulation
compared
pure
while
HCK1T,
much
toxicity
HA-ThCs-Cis
nanoformulation.
These
findings
suggest
system
can
useful
approach
minimize
offtarget
toxicities,
give
better
cellular
uptake
OpenNano,
Journal Year:
2023,
Volume and Issue:
11, P. 100136 - 100136
Published: Feb. 24, 2023
Delivering
drugs
to
tumors
using
nanoparticles
(NPs)
has
shown
promising
potential
in
promoting
targeted
drug
delivery
of
antineoplastic
agents
enhance
their
efficiency
while
reducing
the
associated
systemic
toxicity.
This
review
highlights
different
types
NPs
and
physiological
characteristics
tumor
microenvironment
(TME),
mechanisms
undertaken
safely
deliver
specific
lesions.
We
principles
latest
developments
field
designed
target
vasculature
compared
those
cancer
cells
correlation
with
TME.
discuss
advantages
limitations
each
mechanism
future
directions
aiming
maximize
potential.
