Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 246, P. 114373 - 114373
Published: Nov. 14, 2024
Language: Английский
ACS Nano, Journal Year: 2023, Volume and Issue: 17(6), P. 5187 - 5210
Published: March 10, 2023
Red blood cells (RBCs) and RBC membrane-derived nanoparticles have been historically developed as bioinspired drug delivery systems to combat the issues of premature clearance, toxicity, immunogenicity synthetic nanocarriers. RBC-based possess characteristics including biocompatibility, biodegradability, long circulation time, which make them suited for systemic administration. Therefore, they employed in designing optimal formulations various preclinical models clinical trials treat a wide range diseases. In this review, we provide an overview biology, synthesis, characterization based on RBCs their membrane whole RBCs, membrane-camouflaged nanoparticles, RBC-derived extracellular vesicles, hitchhiking. We also highlight conventional latest engineering strategies, along with therapeutic modalities, enhanced precision effectiveness delivery. Additionally, focus current state applications translation carriers, well discussing opportunities challenges associated these systems.
Language: Английский
Citations
97
Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 197, P. 114861 - 114861
Published: May 6, 2023
Language: Английский
Citations
65
Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)
Published: March 20, 2024
Recent research in artificial cell production holds promise for the development of delivery agents with therapeutic effects akin to real cells. To succeed these applications, systems need survive circulatory conditions. In this review we present strategies that, inspired by endurance red blood cells, have enhanced viability large, cell-like vehicles vivo use, particularly focusing on giant unilamellar vesicles. Insights from cells can guide modifications that could transform platforms into advanced drug vehicles, showcasing biomimicry's potential shaping future applications.
Language: Английский
Citations
16
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(5), P. 4333 - 4333
Published: Feb. 22, 2023
Respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), are critical areas of medical research, millions people affected worldwide. In fact, more than 9 million deaths worldwide were associated with respiratory diseases in 2016, equivalent to 15% global deaths, the prevalence is increasing every year population ages. Due inadequate treatment options, treatments for many limited relieving symptoms rather curing disease. Therefore, new therapeutic strategies urgently needed. Poly (lactic-co-glycolic acid) micro/nanoparticles (PLGA M/NPs) have good biocompatibility, biodegradability unique physical chemical properties, making them one most popular effective drug delivery polymers. this review, we summarized synthesis modification methods PLGA M/NPs their applications (asthma, COPD, cystic fibrosis (CF), etc.) also discussed research progress current status diseases. It was concluded that promising vehicles due advantages low toxicity, high bioavailability, loading capacity, plasticity modifiability. And at end, presented an outlook on future directions, aiming provide some ideas directions hopefully promote widespread application clinical treatment.
Language: Английский
Citations
40
Deleted Journal, Journal Year: 2024, Volume and Issue: 2(3)
Published: June 21, 2024
Abstract Nano drug delivery systems have been widely used in tumor therapy. Researchers devoted to exploring novel nano‐carriers prolong circulation time biocompatibility and targeting efficiency vivo. Erythrocyte membranes as bionic nano‐drug attracted more attention recently. There are abundant red blood cells (RBCs) circulation, which natural carriers for nanomaterial delivery. mainly two strategies use RBCs carriers: RBC‐hitchhiking coated with erythrocyte membrane loading drugs. Although nano‐carrier based on yielded some progress, the mechanism of mutual effect between nanoparticles is still unclear. Here, we review effects (morphology function, etc ) application
Language: Английский
Citations
9
Pharmaceutical Research, Journal Year: 2022, Volume and Issue: 39(11), P. 2673 - 2698
Published: July 7, 2022
Language: Английский
Citations
30
Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)
Published: Aug. 22, 2023
Abstract Red blood cells (RBCs) are the most abundant in body, possessing unique biological and physical properties. RBCs have demonstrated outstanding potential as delivery vehicles due to their low immunogenicity, long-circulating cycle, immune characteristics, exhibiting abilities. There been several developments understanding system of derivatives, they applied various aspects biomedicine. This article compared physiological characteristics RBCs, analyzed advantages systems, summarized existing practices Graphical
Language: Английский
Citations
22
Advanced Materials, Journal Year: 2023, Volume and Issue: unknown
Published: Feb. 21, 2023
Cell therapies are emerging as a promising new therapeutic modality in medicine, generating effective treatments for previously incurable diseases. Clinical success of cell has energized the field cellular engineering, spurring further exploration novel approaches to improve their performance. Engineering surfaces using natural and synthetic materials emerged valuable tool this endeavor. This review summarizes recent advances development technologies decorating with various including nanoparticles, microparticles, polymeric coatings, focusing on ways which surface decorations enhance carrier cells effects. Key benefits surface-modified include protecting cell, reducing particle clearance, enhancing trafficking, masking cell-surface antigens, modulating inflammatory phenotype cells, delivering agents target tissues. While most these still proof-of-concept stage, efficacy constructs from vitro vivo preclinical studies laid strong foundation eventual clinical translation. engineering can imbue diverse range advantages therapy, creating opportunities innovative functionalities, improved efficacy, transforming fundamental translational landscape therapies.
Language: Английский
Citations
20
MedComm, Journal Year: 2025, Volume and Issue: 6(1)
Published: Jan. 1, 2025
Abstract Messenger RNA (mRNA) therapeutics have garnered considerable attention due to their remarkable efficacy in the treatment of various diseases. The COVID‐19 mRNA vaccine and RSV been approved on market. Due inherent nuclease‐instability negative charge mRNA, delivery systems are developed protect from degradation facilitate its crossing cell membrane express functional proteins or peptides cytoplasm. However, deficiency transfection efficiency targeted biological distribution still major challenges for systems. In this review, we first described physiological barriers process then discussed design approach recent advances with an emphasis tissue/cell‐targeted abilities. Finally, pointed out existing future directions deep insights into efficient We believe that a high‐precision system can greatly improve therapeutic effects bio‐safety accelerate clinical transformations. This review may provide new direction serve as useful guide researchers who looking suitable system.
Language: Английский
Citations
0
ACS Nano, Journal Year: 2023, Volume and Issue: 17(22), P. 22430 - 22443
Published: Nov. 7, 2023
Effective accumulation and penetration of antibiotics in the biofilm are critical issues for bacterial infection treatment. Red blood cells (RBCs) have been widely utilized to hitchhike nanocarriers drug delivery. It is vital challenging find a nanocarrier with an appropriate affinity toward RBCs bacteria selective hitchhiking release that determines delivery efficiency specificity. Herein, we report zwitterionic polymer poly(2-(N-oxide-N,N-diethylamino)ethyl methacrylate) (OPDEA)-based micelle, which can on preferentially site. We found OPDEA could bind cell membrane via phospholipid-related transfer Gram-positive due nearly order magnitude stronger interaction wall. The surface cell-wall OPDEA-based micelles also promote their biofilm. clarithromycin-loaded show efficient into site, resulting excellent therapeutic performance both peritonitis pneumonia models by intravenous or spray administration. This simple RBC-selective releasing antibiotic system provides promising strategy design antibacterial nanomedicines.
Language: Английский
Citations
10