Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: 35(11), P. 109576 - 109576
Published: Jan. 29, 2024
Language: Английский
MedComm – Oncology, Journal Year: 2024, Volume and Issue: 3(1)
Published: March 1, 2024
Abstract Rapid growth in nanoparticles (NPs) as delivery systems holds vast promise to promote therapeutic approaches for cancer treatment. Presently, a diverse array of NPs with unique properties have been developed overcome different challenges and achieve sophisticated routes enhancement series therapies. Inspiring advances achieved the field therapy using NPs. In this review, we aim summarize up‐to‐date progression addressing various challenges, expect elicit novel potential opportunities alternatively. We first introduce sorts NP technologies, illustrate their mechanisms, present applications. Then, achievements made by break obstacles delivering cargoes specific sites through particular are highlighted, including long‐circulation, tumor targeting, responsive release, subcellular localization. subsequently retrospect recent research treatments from single therapy, like chemotherapy, combination chemoradiotherapy, integrative therapy. Finally, perspectives impact on oncology discussed. believe review can offer deeper understanding
Language: Английский
Citations
32
Small, Journal Year: 2024, Volume and Issue: 20(43)
Published: July 14, 2024
This review explores the evolution of lipid-based nanoparticles (LBNPs) for drug delivery (DD). Herein, LBNPs are classified into liposomes and cell membrane-based (CMNPs), each with unique advantages challenges. Conventional possess drawbacks such as poor targeting, quick clearance, limited biocompatibility. One possible alternatives to overcome these challenges is surface modification (NPs) materials polyethylene glycol (PEG), aptamers, antibody fragments, peptides, CD44, hyaluronic acid, folic palmitic lactoferrin. Thus, main focus this will be on different modifications that enable have beneficial properties DD, enhancing mass transport properties, immune evasion, improved stability, targeting. Moreover, various CMNPs explored used DD derived from cells red blood (RBCs), platelets, leukocytes, cancer cells, stem highlighting their natural (e.g., biocompatibility ability evade system). discussion extends biomimicking hybrid NPs accomplished through coating synthetic (mainly polymeric) membranes. aims provide a comprehensive resource researchers recent advances in field CMNPs. Overall, provides valuable insights dynamic systems.
Language: Английский
Citations
20
Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 184, P. 117897 - 117897
Published: Feb. 7, 2025
Language: Английский
Citations
2
Asian Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 101040 - 101040
Published: Feb. 1, 2025
Language: Английский
Citations
2
Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 165, P. 115049 - 115049
Published: June 25, 2023
The management and treatment of disease are achieved via the use pharmacologically active substances or drugs. Drugs do not, however, have an intrinsic ability to be effective; rather, how well they work depends on administered supplied. Treatment a variety biological illnesses, such as autoimmune disorders, cancer, bacterial infections, requires effective drug delivery. Drug absorption, distribution, metabolism, duration therapeutic impact, pharmacokinetics, excretion, toxicity can all impacted by administration. Improved chemistry materials required for delivery concentration novel treatments specified targets within body, necessary time. This requirement is accompanied development new therapeutics. Formulating medication DDS promising strategy directly addressing numerous typical barriers adherence, frequent dosage, side effects, delayed beginning action. In current review, we give compendium controlled release subsequently highlight some newest developments in realm, with particular emphasis cutting-edge methods targeted therapy. each instance, outline obstacles efficient administration chemical material that allowing sector overcome these positive clinical impact.
Language: Английский
Citations
27
Exploration, Journal Year: 2024, Volume and Issue: 4(6)
Published: March 28, 2024
Abstract Because therapeutic cancer vaccines can, in theory, eliminate tumor cells specifically with relatively low toxicity, they have long been considered for application repressing progression. Traditional containing a single or few discrete epitopes failed the clinic, possibly due to challenges epitope selection, target downregulation, cell heterogeneity, microenvironment immunosuppression, lack of vaccine immunogenicity. Whole membrane vaccines, which provide rich source antigens, are emerging as viable alternatives. Autologous and allogenic cellular evaluated clinical treatments. Tumor membranes (TCMs) an intriguing antigen source, membrane‐accessible targets and, at same time, serve integrated carriers adjuvants other agents. This review provides summary properties technologies TCM vaccines. Characteristics, categories, mechanisms, preparation methods discussed, demonstrable additional benefits derived from combining chemotherapy, sonodynamic therapy, phototherapy, oncolytic viruses. Further research chemistry, biomedicine, immunology, bioinformatics address current drawbacks could facilitate adoption
Language: Английский
Citations
15
Theranostics, Journal Year: 2024, Volume and Issue: 14(6), P. 2490 - 2525
Published: Jan. 1, 2024
Inflammatory dysregulation is intimately associated with the occurrence and progression of many life-threatening diseases.Accurate detection timely therapeutic intervention on inflammatory are crucial for effective therapy inflammation-associated diseases.However, clinical outcomes inflammation-involved disorders still unsatisfactory.Therefore, there an urgent need to develop innovative anti-inflammatory strategies by integrating emerging technological innovations traditional therapeutics.Biomedical nanotechnology one promising fields that can potentially transform diagnosis treatment inflammation.In this review, we outline recent advances in biomedical inflammation, special attention paid nanosensors nanoprobes precise inflammation-related diseases, nanotherapeutics, as well nanotheranostics combined applications.Moreover, prospects challenges translation nanomedicines highlighted.
Language: Английский
Citations
15
ACS Nano, Journal Year: 2024, Volume and Issue: 18(3), P. 2162 - 2183
Published: Jan. 10, 2024
Neutral nanomaterials functionalized with PEG or similar molecules have been popularly employed as nanomedicines. Compared to positive counterparts that are capable of harnessing the well-known proton sponge effect facilitate their escape from lysosomes, it is yet unclear how neutral substances got entry into cytosol. In this study, by taking PEGylated, Au nanospheres an example, we systematically investigated time-dependent translocation postuptake. Specifically, harnessed dissipative particle dynamics simulations uncover bypass lysosomal entrapment, wherein a mechanism termed "squeezing-out" mode was discovered. We next conducted comprehensive investigation on implicate lysosomes in terms integrity and functionality. By using single-molecule imaging, specific preservation PEG-terminated targeting moieties supports underlying nanomaterials. All evidence points out such process benign proceeds at expense loss. Furthermore, proved fine-tuning efficacy escaping modulation distinct pathways metabolic machinery can be achieved readily, thereby offering us simple robust tool cells.
Language: Английский
Citations
14
ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(27), P. 34607 - 34619
Published: June 26, 2024
Photothermal therapy (PTT), which uses the high thermal conversion ability of photothermal agents to ablate tumor cells at temperatures, has gained significant attention because it advantages selectivity and specificity, precise targeting sites, low invasiveness trauma. However, PTT guided by NIR-I limitations in tissue penetration depth, resulting limited imaging monitoring therapeutic effects on deep-seated tissues. Moreover, nanoparticles are easily cleared immune system difficult passively target sites during process treatment. To address these issues, we prepared using NIR-II dyes IR1048 DSPE-PEG-OH further encapsulated them red blood cell membranes derived from mice. These biomimetic nanoparticles, called RDIR1048, showed reduced clearance had long circulation characteristics. They effectively accumulated strong fluorescence could still be observed site 96 h after administration. Furthermore, through mouse experiments, found that RDIR1048 exhibited good ability. When used combination with an checkpoint inhibitor, anti-PD-L1 antibodies, enhanced immunogenic death caused improved effect immunotherapy, demonstrated efficacy treatment tumor-bearing This study provides a feasible basis for future development properties.
Language: Английский
Citations
9
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 10, 2025
Biological carriers have emerged as significant tools to deliver radionuclides in nuclear medicine, providing a meaningful perspective for tumor imaging and treatment. Various radionuclide-labeled biological been developed meet the needs of biomedical applications. This review introduces principles radionuclide-mediated therapy selected criteria them, well comprehensive description characteristics functions representative including bacteria, cells, viruses, their derivatives, emphasizing labeled strategies combined with radionuclides. Subsequently, we in-depth introduce application treatment, behaviors vivo metastasis treatment by radionuclide therapy, plus other radiation-induced photodynamic therapy. Finally, challenges prospects are discussed improve shortcomings this innovative platform promote clinical transformation field medical imaging.
Language: Английский
Citations
1