Microfluidic formulation of anticancer peptide loaded ZIF-8 nanoparticles for the treatment of breast cancer

Journal of Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 642, P. 810 - 819

Published: March 30, 2023

Language: Английский

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A Review of Microfluidic Experimental Designs for Nanoparticle Synthesis

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(15), P. 8293 - 8293

Published: July 27, 2022

Microfluidics is defined as emerging science and technology based on precisely manipulating fluids through miniaturized devices with micro-scale channels chambers. Such microfluidic systems can be used for numerous applications, including reactions, separations, or detection of various compounds. Therefore, due to their potential microreactors, a particular research focus was noted in exploring microchannel configurations on-chip chemical syntheses materials tailored properties. Given the significant number studies field, this paper aims review recently developed geometry particularities, starting from brief presentation nanoparticle synthesis mixing within microchannels, further moving more detailed discussion different chip use nanomaterial fabrication.

Language: Английский

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Curcumin delivery and co-delivery based on nanomaterials as an effective approach for cancer therapy

Journal of Drug Delivery Science and Technology, Journal Year: 2022, Volume and Issue: 78, P. 103982 - 103982

Published: Nov. 12, 2022

Language: Английский

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Microfluidic systems for particle capture and release: A review

Biosensors and Bioelectronics, Journal Year: 2023, Volume and Issue: 236, P. 115426 - 115426

Published: May 25, 2023

Language: Английский

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Nanoparticle Synthesis and Their Integration into Polymer-Based Fibers for Biomedical Applications

Biomedicines, Journal Year: 2023, Volume and Issue: 11(7), P. 1862 - 1862

Published: June 29, 2023

The potential of nanoparticles as effective drug delivery systems combined with the versatility fibers has led to development new and improved strategies help in diagnosis treatment diseases. Nanoparticles have extraordinary characteristics that are helpful several applications, including wound dressings, microbial balance approaches, tissue regeneration, cancer treatment. Owing their large surface area, tailor-ability, persistent diameter, also used for engineering, controlled delivery, protective clothing. combination power generate enhanced performance over individual architectures. This review aims at illustrating main possibilities trends functionalized nanoparticles, focusing on inorganic organic polymer-based fibers. Emphasis recent progress fabrication procedures types description most polymers produce been undertaken, along bioactivity such alliances biomedical applications. To finish, future perspectives incorporated within clinical use presented discussed, thus showcasing relevant paths follow success field.

Language: Английский

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Therapeutic effects of curcumin liposomes and nanocrystals on inflammatory osteolysis: In vitro and in vivo comparative study

Pharmacological Research, Journal Year: 2023, Volume and Issue: 192, P. 106778 - 106778

Published: April 23, 2023

Curcumin could inhibit periprosthetic osteolysis induced by wear debris and adherent endotoxin, which commonly cause prosthesis loosening negatively influence the long-term survival of joint arthroplasty. However, its limited water solubility poor stability pose challenges for further clinical application. To address these issues, we developed curcumin liposomes intraarticular injection, as possess good lubricant capacity pharmacological synergy with curcumin. Additionally, a nanocrystal dosage form was prepared to enable comparison based on their ability disperse effectively. A microfluidic method used controllability, repeatability, scalability. The Box-Behnken Design employed screen formulations flow parameters, while computational fluid dynamics simulate mixing process predict formation liposomes. optimized (Cur-LPs) had size 132.9 nm an encapsulation efficiency 97.1%, whereas nanocrystals (Cur-NCs) 172.3 nm. Both Cur-LPs Cur-NCs inhibited LPS-induced pro-inflammatory polarization macrophages reduced expression secretion inflammatory factors. mouse air pouch model demonstrated that both forms attenuated cell infiltration fibrosis in subcutaneous tissues. Interestingly, anti-inflammatory effect more potent than Cur-NCs, vitro vivo, although cellular uptake quicker. In conclusion, results demonstrate have great potential treatment therapeutic is closely related liposomal form.

Language: Английский

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A novel micromixer based on coastal fractal for manufacturing controllable size liposome

Physics of Fluids, Journal Year: 2024, Volume and Issue: 36(11)

Published: Nov. 1, 2024

The traditional lipid preparation methods are complex, time-consuming, and consume a large amount of reagents, increasing costs difficulties. Although microfluidic technology is considered promising solution, achieving controllable liposome production with simple inexpensive mixing device remains an important problem. This paper presents wall-type micro-mixer based on coastal zone fractals. Four parameters related to the geometric shape coastline fractal in microchannel used as design variables, index objective function. Single-objective optimization numerical analysis primary baffle micromixer under four Reynolds numbers conditions yields optimal structural configuration. Visualization experiments verify correctness accuracy simulation, optimized mixer produce liposomes. results show that double-sidewall cross arrangement enhances chaotic convection improves efficiency. At Re = 0.1 100, efficiency reaches 99%, 50.44% higher than reference design. By changing relative flow rates aqueous solutions, blank liposomes particle size 165.12 ± 11.6 nm polydispersity 0.35± obtained. has broad application prospects due its high

Language: Английский

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Microfluidic Formulation of Curcumin-Loaded Multiresponsive Gelatin Nanoparticles for Anticancer Therapy

ACS Biomaterials Science & Engineering, Journal Year: 2023, Volume and Issue: 9(6), P. 3402 - 3413

Published: May 4, 2023

Current anticancer research shows that a combination of multiple treatment methods can greatly improve the killing tumor cells. Using latest microfluidic swirl mixer technology, combined with chemotherapy and photothermal-ablation therapy, we developed multiresponsive targeted antitumor nanoparticles (NPs) made folate-functionalized gelatin NPs under 200 nm in size encapsulated CuS NPs, Fe3O4 curcumin (Cur). By exploring gelatin's structure, adjusting its concentration pH, fine-tuning fluid dynamics device, best preparation conditions were obtained for an average particle 90 ± 7 nm. The comparative targeting drug delivery system (DDS) was demonstrated on lung adenocarcinoma A549 cells (low level folate receptors) breast MCF-7 (high receptors). Folic acid helps achieve accurate to synergistic photothermal ablation curcumin's activity are achieved through infrared light irradiation (980 nm), while is guided external magnetic field target accelerate uptake drugs, thus efficiently method described this work simple, easy repeat, has great potential be scaled up industrial production subsequent clinical use.

Language: Английский

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Non-viral delivery of nucleic acid for treatment of rare diseases of the muscle

Journal of Biosciences, Journal Year: 2024, Volume and Issue: 49(1)

Published: Feb. 16, 2024

Language: Английский

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Optimizing nanoliposomal formulations: Assessing factors affecting entrapment efficiency of curcumin-loaded liposomes using machine learning

International Journal of Pharmaceutics, Journal Year: 2023, Volume and Issue: 646, P. 123414 - 123414

Published: Sept. 14, 2023

Language: Английский

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