Nanocarriers in topical photodynamic therapy DOI
Nina Dragičević, Jelena Predic-Atkinson, B Nikolić

et al.

Expert Opinion on Drug Delivery, Journal Year: 2024, Volume and Issue: 21(2), P. 279 - 307

Published: Feb. 1, 2024

Introduction Photodynamic therapy (PDT) has gained significant attention due to its superiority over conventional treatments. In the context of skin cancers and nonmalignant diseases, topical application photosensitizer formulations onto affected skin, followed by illumination, offers distinct advantages. Topical PDT simplifies providing easy access increasing drug concentration within target area, confining residual photosensitivity treated skin. However, effectiveness is often hindered challenges such as limited penetration or instability. Additionally, hypoxic tumor environment poses further limitations. Nanocarriers present a promising solution address these challenges.

Language: Английский

The potential use of therapeutics and prophylactic mRNA vaccines in human papillomavirus (HPV) DOI Creative Commons

Fatemeh Movahed,

Satinik Darzi,

Parya Mahdavi

et al.

Virology Journal, Journal Year: 2024, Volume and Issue: 21(1)

Published: May 31, 2024

Abstract Cervical cancer (CC) and other malignant malignancies are acknowledged to be primarily caused by persistent human papillomavirus (HPV) infection. Historically, vaccinations against viruses that produce neutralizing antibodies unique the virus have been an affordable way manage viral diseases. CC risk is decreased, but not eliminated, HPV vaccinations. Since made available globally, almost 90% of infections successfully avoided. On lesions diseases already present, however, no discernible treatment benefit has shown. As a result, therapeutic vaccines elicit immune responses mediated cells necessary for established cancers. mRNA possess remarkable potential in combating malignancy as result their superior industrial production, safety, efficacy. Furthermore, considering expeditiousness vaccine exhibits promise approach targeting HPV. Given HPV-encoded early proteins, including oncoproteins E6 E7, consistently present HPV-related cancers pre-cancerous crucial functions progression persistence diseases, they serve ideal targets vaccines. The action mechanism vaccines, recent advancements clinical trials, applications highlighted this study, which also offers quick summary state Lastly, we highlight few difficulties with vaccination practice provide our thoughts on further quickly changing sector. It expected will soon produced prevention treatment. Graphical

Language: Английский

Citations

13
Polymeric and non-polymeric oxaliplatin nanomedicine for cancer therapy: A comprehensive review DOI
Mehrab Pourmadadi,

Meysam Shaghaghi,

Rabia Arshad

et al.

European Polymer Journal, Journal Year: 2024, Volume and Issue: 208, P. 112870 - 112870

Published: Feb. 23, 2024

Language: Английский

Citations

11
Fabrication of magnetic niosomal platform for delivery of resveratrol: potential anticancer activity against human pancreatic cancer Capan-1 cell DOI Creative Commons

Akram Firouzi Amandi,

Zahra Bahmanyar,

Mehdi Dadashpour

et al.

Cancer Cell International, Journal Year: 2024, Volume and Issue: 24(1)

Published: Jan. 29, 2024

Abstract Recently, the presence of different nanoparticles (NPs) has developed targeting drug delivery in treatment cancer cell. Targeted systems using NPs have shown great promise improving efficacy intracellular uptake as well local concentration therapeutics with minimizing side effects. The current study planned to synthesized resveratrol-loaded magnetic niosomes (RSV-MNIONPs) and evaluate their cytotoxicity activity pancreatic cells. For this aim, (MNPs) were loaded into (NIOs) by thin film hydration technique then characterized via DLS, FT-IR, TEM, SEM VSM techniques. Moreover, cytotoxic RSV-MNIONPs on Capan-1 cells line was assessed MTT test. distribution number gained about 80 nm 95 surface charge − 14.0 mV TEM analysis, respectively. RSV loading NIOs 85%, releases pattern displayed a sustained discharge maximum amount 35% 40%, within 4 h pH = 7.4 5.8, an external field is higher than that RSV, indicating enhanced cellular encapsulated states. Furthermore, MNNPs found induce more cell cycle arrest at G0/G1 checkpoint free RSV. Compared RSV-treated cells, mRNA expression levels BAX, Bcl2, FAS, P 53, Cyclin D hTERT, significantly changed treated MNNPs. approaches been widely used attain solubility, improved bioavailability, stability, control Our formulation antitumor can be considered appropriate carrier potential for future usage therapy.

Language: Английский

Citations

10
Exploring the potential of silymarin-loaded nanovesicles as an effective drug delivery system for cancer therapy: in vivo, in vitro, and in silico experiments DOI
Mohammad Reza Hajinezhad,

Maryam Roostaee,

Zahra Nikfarjam

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: 397(9), P. 7017 - 7036

Published: April 17, 2024

Language: Английский

Citations

10
Nanocarriers in topical photodynamic therapy DOI
Nina Dragičević, Jelena Predic-Atkinson, B Nikolić

et al.

Expert Opinion on Drug Delivery, Journal Year: 2024, Volume and Issue: 21(2), P. 279 - 307

Published: Feb. 1, 2024

Introduction Photodynamic therapy (PDT) has gained significant attention due to its superiority over conventional treatments. In the context of skin cancers and nonmalignant diseases, topical application photosensitizer formulations onto affected skin, followed by illumination, offers distinct advantages. Topical PDT simplifies providing easy access increasing drug concentration within target area, confining residual photosensitivity treated skin. However, effectiveness is often hindered challenges such as limited penetration or instability. Additionally, hypoxic tumor environment poses further limitations. Nanocarriers present a promising solution address these challenges.

Language: Английский

Citations

9