Cogent Engineering,
Journal Year:
2024,
Volume and Issue:
11(1)
Published: Nov. 27, 2024
Electrospun
nanofibers
have
been
identified
for
their
outstanding
capability
in
advancing
biomedical
applications
focused
on
enhancing
human
well-being,
consequently
leading
to
a
significant
transformation
healthcare.
The
electrospinning
technique
is
remarkably
straightforward
implement
and
has
facilitated
the
fabrication
of
structures
possessing
unique
highly
advantageous
properties
encompassing
wide
variety
applications.
This
review
examines
technology,
recent
improvements
aimed
at
increasing
nanofiber
yield,
methods
used
achieve
these
enhancements.
It
highlights
various
polymers
electrospinning,
along
with
biocompatibility
bioactivity.
article
also
underscores
contribution
electrospun
polymeric
domain
while
shedding
light
present
difficulties,
like
issues
tied
scalability,
reproducibility,
compliance
regulations.
Prospective
advancements
encompass
developments
material
science,
harmonization
emerging
technologies,
innovative
that
could
amplify
influence
healthcare
outcomes.
By
providing
comprehensive
analysis,
this
paper
emphasizes
groundbreaking
impact
health
sciences
ability
substantially
advance
advancements.
Drug Development and Industrial Pharmacy,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 12
Published: Jan. 16, 2025
The
objective
of
the
study
was
to
tackle
recurrence
prostate
cancer
(PCa)
post-surgery
and
re-sensitize
docetaxel
(DTX)-resistant
PC-3
cells
chemo-therapy
using
NIC.
Prolonged
DTX
therapy
leads
emergence
chemo-resistance
by
overexpression
PI3K-AKT
pathway
in
PCa
along
with
tumor
post-surgery.
Suppression
this
could
be
essential
improving
anticancer
activity
re-sensitizing
resistant
cells.
Niclosamide
(NIC),
an
anthelmintic
drug
has
shown
tremendous
potential
re-sensitized
various
drugs.
To
mitigate
post-surgical
recurrence,
implant-based
system
facilitating
sustained
release
NIC
beneficial.
were
incorporated
within
a
nanofiber
(NF)
prevent
on-site
local
DTX-resistant
fabricated
DTX-NIC
NF
via
electrospinning
334
±
96.14
nm
diameter
demonstrated
profile
till
6
d.
Elevated
mitochondrial
damage,
reactive
oxygen
species
levels
apoptotic
index
revealed
improvement
cytotoxicity
post
incorporation
into
owing
their
profile.
Re-sensitization
PC-3/DTX
observed
introduction
which
due
suppression
p-Akt1,
overexpressed
From
superior
re-sensitization
cells,
we
conclude
that
beneficial
therapeutic
regimen
preventing
PCa.
Breast Cancer Basic and Clinical Research,
Journal Year:
2024,
Volume and Issue:
18
Published: Jan. 1, 2024
Despite
recent
improvements
in
detecting
and
managing
breast
cancer
(BC),
it
continues
to
be
a
major
worldwide
health
concern
that
annually
affects
millions
of
people.
Exploring
the
anti-BC
potentials
natural
compounds
has
received
lot
scientific
attention
due
their
multi-target
mode
action
good
safety
profiles
because
these
unmet
needs.
Drugs
made
from
herbs
are
secure
have
fewer
negative
effects
than
those
synthetic
materials.
Early
stage
patients
benefit
breast-conserving
surgery,
but
risk
local
recurrence
remains,
necessitating
implanted
scaffolds.
These
scaffolds
provide
residual
cell
killing
tailored
drug
delivery.
This
review
looks
at
plant
extract–infused
tissue
engineering
scaffolds,
which
novel
approach
treating
BC.
By
offering
patient
individualized,
safer
treatments,
could
completely
change
how
BC
is
treated.
PubMed,
Journal Year:
2024,
Volume and Issue:
23, P. 143 - 179
Published: Jan. 1, 2024
Conventional
cancer
chemotherapy
regimens,
albeit
successful
to
some
extent,
suffer
from
significant
drawbacks,
such
as
high-dose
requirements,
limited
bioavailability,
low
therapeutic
indices,
emergence
of
multiple
drug
resistance,
off-target
distribution,
and
adverse
effects.
The
main
goal
developing
implantable
delivery
systems
(IDDS)
is
address
these
challenges
maintain
anti-cancer
drugs
directly
at
the
intended
sites
action
while
minimizing
inevitable
side
IDDS
possess
numerous
advantages
over
conventional
delivery,
including
controlled
release
patterns,
one-time
administration,
well
loading
stabilizing
poorly
water-soluble
drugs.
Here,
we
summarized
novel
(three-dimensional
(3D)
printing
microfluidic)
preparation
techniques
different
IDDS,
nanofibers,
films,
hydrogels,
wafers,
sponges,
osmotic
pumps.
These
could
be
designed
with
high
biocompatibility
biodegradability
features
using
a
wide
variety
natural
synthetic
polymers.
We
also
reviewed
published
data
on
in
therapy
particular
focus
their
behavior.
Various
profiles
attained
which
enable
predictable,
adjustable,
sustained
releases.
Furthermore,
multi-step
or
stimuli-responsive
obtained
systems.
studies
mentioned
this
article
have
proven
effectiveness
for
treating
types
prevalence,
breast
cancer,
aggressive
types,
glioblastoma
liver
cancer.
Additionally,
applying
efficacious
potential
future
developments
are
discussed.
Considering
further
advancements,
programmable
degradation
features,
clinical
trials
needed
ensure
efficiency.
overall
review
expand
our
understanding
behavior
commonly
investigated
identify
barriers
that
should
addressed
pursuit
more
efficient
therapies
See
graphical
abstract(Fig.
1).
