International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 124844 - 124844
Published: Oct. 1, 2024
Language: Английский
REVIEWS ON ADVANCED MATERIALS SCIENCE, Journal Year: 2022, Volume and Issue: 61(1), P. 901 - 930
Published: Jan. 1, 2022
Abstract Today, the growth of cosmetic industry and dramatic technological advances have led to creation functional cosmetical products that enhance beauty health. Such can be defined as topical drugs improve health functions or benefits. Implementing nanotechnology advanced engineering in these has enabled innovative product formulations solutions. The search included organic molecules used cosmeceuticals nanoparticles (NPs) field. As a result, this document analyses use inorganic particles, metals, metal-oxides, carbon-based particles. Additionally, includes lipid solid systems. In conclusion, using NPs vehicles active substances is potential tool for transporting ingredients. Finally, review while presenting progress made highlighting hidden challenges associated with nanocosmeceuticals.
Language: Английский
Citations
14
Journal of Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 646, P. 290 - 300
Published: May 12, 2023
Polyphosphate nanoparticles as phosphatase-degradable carriers for Penicillium chrysogenum antifungal protein (PAF) can enhance the activity of against Candida albicans biofilm.PAF-polyphosphate (PP) (PAF-PP NPs) were obtained through ionic gelation. The resulting NPs characterized in terms their particle size, size distribution and zeta potential. Cell viability hemolysis studies carried out vitro on human foreskin fibroblasts (Hs 68 cells) erythrocytes, respectively. Enzymatic degradation was investigated by monitoring release free monophosphates presence isolated well C. albicans-derived phosphatases. In parallel, shift potential PAF-PP a response to phosphatase stimuli determined. Diffusion PAF biofilm matrix analysed fluorescence correlation spectroscopy (FCS). Antifungal synergy evaluated determining colony forming units (CFU).PAF-PP with mean 300.9 ± 4.6 nm -11.2 2.8 mV. toxicity assessments revealed that highly tolerable Hs cells erythrocytes similar PAF. Within 24 h, 21.9 0.4 μM monophosphate released upon incubation having final concentration 156 μg/ml (2 U/ml) leading up -0.7 0.3 This from also observed extracellular diffusivity within 48 h old enhanced decreasing survival pathogen 7-fold comparison naked conclusion, hold promise nanocarriers augment enable its efficient delivery treatment infections.
Language: Английский
Citations
7
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: Feb. 6, 2024
Abstract Obesity is a major risk to human health. Adipogenesis blocked by α-tocopherol and conjugated linoleic acid (CLA). However, their effect at preventing obesity uncertain. The effectiveness of the bioactive agents associated with delivery method. Herein, we designed CLA-loaded tocol nanostructured lipid carriers (NLCs) for enhancing anti-adipogenic activity CLA. inhibition nanocarriers was examined using an in vitro adipocyte model vivo rat fed high fat diet (HFD). targeting NLCs into adipocytes adipose tissues were also investigated. A synergistic anti-adipogenesis observed combination free Nanoparticles different amounts solid developed average size 121‒151 nm. smallest (121 nm) showed greater internalization differentiation prevention than larger size. small-sized promoted CLA 5.5-fold as compared control. reduced accumulation counteracting expression adipogenic transcription factors peroxisome proliferator activated receptor (PPAR)γ CCAAT/enhancer-binding protein (C/EBP)α, lipogenic enzymes acetyl-CoA carboxylase (ACC) fatty synthase (FAS). Localized administration significantly body weight, total cholesterol, liver damage indicators obese rats. biodistribution study demonstrated that nanoparticles mainly accumulated tissues. decreased hypertrophy cytokine overexpression groin epididymis degree In conclusion, lipid-based verified inhibit adipogenesis efficient safe way.
Language: Английский
Citations
2
Food Research, Journal Year: 2024, Volume and Issue: 8(3), P. 363 - 375
Published: June 8, 2024
Red palm oil (RPO) is a potential carotenoid source mostly containing β-carotene. RPO instability requires delivery system such as nanostructured lipid carriers (NLC). This research aimed to develop an NLC and study the characteristics of NLCRPO. The melting-emulsification-ultrasonication method was employed produce NLC-RPO based on 6% (w/w) lipids, with solid ratio (SRR) varied 6:4, 7:3, 8:2. Tween 80 (24% w/w) lipids 4:1, distilled water 70% (w/w). in this investigation were stearin (PS), kernel (PKS), while liquid RPO. stability evaluated using βcarotene entrapment efficiency (EE), centrifugation, cooling, heating test, color, pH for 90 days storage. characterized by particle size, polydispersity index (PDI), zeta potential, viscosity before after days. Regression analysis performed evaluate relationships between storage parameters. highest encapsulation β-carotene carrier from achieved when 6:4 there no significant difference type (PS PKS) used. Generally, stored at room temperature showed good cooling tests greenish-yellow color (-a*;+b*), 6.38-6.54. size (38-87 nm), PDI (0.01-0.54), (-10.17 -22.67 mV) did not significantly change over storage, (8.36-9.11cP) different. SRR had remained stable temperature.
Language: Английский
Citations
2
Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 346, P. 122642 - 122642
Published: Aug. 22, 2024
Language: Английский
Citations
2
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 12343 - 12368
Published: Nov. 1, 2024
The intranasal (IN) route of drug delivery can effectively penetrate the blood-brain barrier and deliver drugs directly to brain for treatment central nervous system (CNS) disorders via intra-neuronal or extra-neuronal pathways. This approach has several advantages, including avoidance first-pass metabolism, high bioavailability, ease administration, improved patient compliance. In recent years, an increasing number studies have been conducted using encapsulated in solid lipid nanoparticles (SLNs) nanostructured carriers (NLCs), delivering them IN pathway. SLNs are first-generation nanocarriers, known their excellent biocompatibility, drug-loading capacity, remarkable stability. NLCs, regarded as second-generation SLNs, not only retain advantages but also exhibit enhanced stability, preventing leakage during storage. this review, we examined vivo between 2019 2024 that used NLCs address CNS route. By statistical methods evaluate pharmacokinetic parameters, found markedly accumulation targeting within brain. Additionally, pharmacodynamic evaluations indicated method substantially therapeutic effectiveness alleviating symptoms rat models diseases. addition, enhancing efficacy nose-to-brain discussed, well advances clinical trials regarding NLCs.
Language: Английский
Citations
2
Food Bioscience, Journal Year: 2023, Volume and Issue: 53, P. 102707 - 102707
Published: May 18, 2023
Language: Английский
Citations
6
International Journal of Pharmaceutics, Journal Year: 2023, Volume and Issue: 646, P. 123474 - 123474
Published: Oct. 2, 2023
The current study aimed to develop enzyme-activated charge-reversal lipid nanoparticles (LNPs) as novel gene delivery systems.Palmitic acid was covalently bound protamine being utilised transfection promoter anchor it on the surfaces of LNPs. Green fluorescent protein (GFP) encoding plasmid DNA (pDNA) ion paired with various cationic counter ions achieve high encapsulation in Protamine-decorated LNPs were prepared by solvent injection method followed coating sodium tripolyphosphate (TPP) generate a bio-inert anionic outer surface. Resulting characterised regarding size, polydispersity, zeta potential and efficiency. Enzyme-triggered investigated using isolated alkaline phosphatase (ALP) monitoring changes well monophosphate release. Furthermore, release, cell viability efficiency evaluated human alveolar epithelial (A549) line.Protamine-decorated TPP-coated (Prot-pDNA/DcChol-TPP) displayed mean size 298.8 ± 17.4 nm -13.70 0.61 mV. High pDNA achieved hydrophobic pairs 3ß-[N-(N',N'-dimethylaminoethane)-carbamoyl]cholesterol hydrochloride (DcChol). Zeta Prot-pDNA/DcChol-TPP reversed positive values total Δ26.8 mV shift upon incubation ALP. Conformably, notable amount released cell-associated A549 cells tolerated displaying more than 95 % viability. Compared naked pDNA, unmodified control LNPs, showed significantly increased efficiency.Prot-pDNA/DcChol-TPP can be regarded promising systems.
Language: Английский
Citations
4
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(11), P. 2530 - 2530
Published: Oct. 25, 2023
The therapeutic effectiveness of paliperidone in the treatment schizophrenia has been limited by its poor oral bioavailability; hence, an alternative route could be appropriate. This study investigates feasibility developing a buccal film impregnated with paliperidone-loaded nanostructured lipid carriers (NLCs) and assesses potential to enhance bioavailability. Box-Behnken-based design optimization NLCs was performed examining particles' physical characteristics. polymeric used load optimized NLCs, which were then assessed for their pharmaceutical properties, permeability, pharmacokinetics. outcomes indicated that selected formulation variables had considerable (p < 0.05) impact on responses such as particle size, entrapment efficiency, % drug release. Desired characteristics negative charge, higher nanoparticles ideal size distribution shown NLC dispersions. developed demonstrated excellent physico-mechanical appropriate texture, good excipient compatibility (chemically stable formulation), amorphous nature. A sustained Weibull model release 0.0005) superior flux (~5-fold higher, p 0.005) seen NLC-loaded compared plain-drug-loaded film. pharmacokinetics profile rabbits supports goal therapy evidenced significantly AUC0-12 0.0001) greater relative bioavailability (236%) than control. These results support conclusion alternate effective administration schizophrenia.
Language: Английский
Citations
4
International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 654, P. 123983 - 123983
Published: March 7, 2024
The study aimed to develop enzyme-degradable nanoparticles comprising polyphosphates and metal cations providing sustained release of the antibacterial drug ethacridine (ETH). Calcium polyphosphate (Ca-PP), zinc (Zn-PP) iron (Fe-PP NPs) were prepared by co-precipitation sodium with ETH. Developed nanocarriers characterized regarding particle size, PDI, zeta potential, encapsulation efficiency loading. Toxicological profile was assessed via hemolysis assay cell viability on human blood erythrocytes HEK-293 cells, respectively. enzymatic degradation NPs evaluated in presence alkaline phosphatase (ALP) monitoring monophosphate, shift potential size as well release. efficacy against Escherichia coli determined microdilution assay. obtained a range between 300–––480 nm displaying negative values. Encapsulation 83.73 % – 95.99 %. Hemolysis underlined sufficient compatibility whereas showed concentration dependent effect cells viability. Ca- Zn-PP exhibited remarkable changes monophosphate upon incubation ALP, compared Fe-PP showing only minor differences. released ETH from retained activity E. coli, no observed NPs. Polyphosphate cross-linked divalent hold promise for delivery triggered ALP parental administration.
Language: Английский
Citations
1