ENHANCING QUALITY-BY-DESIGN THROUGH WEIGHTED GOAL PROGRAMMING: A CASE STUDY ON FORMULATION OF ULTRADEFORMABLE LIPOSOMES DOI

Sonia Valverde Cabeza,

Pedro Luis González Rodríguez, Marı́a Luisa González-Rodrı́guez

et al.

Drug Development and Industrial Pharmacy, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 28

Published: Feb. 24, 2025

Introduction Optimization of pharmaceutical formulations requires advanced tools to ensure quality, safety, and efficacy. Quality-by-Design (QbD), introduced by the FDA, emphasizes understanding controlling processes early in development. Advanced optimization methods, such as desirability, have surpassed traditional single-objective techniques. Others Weighted Goal Programming (WGP) offers unique advantages integrating decision-maker preferences, enabling balanced solutions for complex drug delivery systems. This study applies WGP optimize timolol-loaded nanoliposomes aligning with QbD principles.

Language: Английский

Vesicular Drug Delivery Systems: Promising Approaches in Ocular Drug Delivery DOI Creative Commons
E. Batur, Samet Özdemir, Meltem Ezgi Durgun

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(4), P. 511 - 511

Published: April 16, 2024

Ocular drug delivery poses unique challenges due to the complex anatomical and physiological barriers of eye. Conventional dosage forms often fail achieve optimal therapeutic outcomes poor bioavailability, short retention time, off-target effects. In recent years, vesicular systems have emerged as promising solutions address these challenges. Vesicular systems, such liposome, niosome, ethosome, transfersome, others (bilosome, transethosome, cubosome, proniosome, chitosome, terpesome, phytosome, discome, spanlastics), offer several advantages for ocular delivery. These include improved prolonged time on surface, reduced systemic side effects, protection drugs from enzymatic degradation dilution by tears. Moreover, formulations can be engineered targeted specific tissues or cells, enhancing efficacy while minimizing They also enable encapsulation a wide range molecules, including hydrophilic, hydrophobic, macromolecular drugs, possibility combination therapy facilitating co-delivery multiple drugs. This review examines their over conventional production techniques, applications in management diseases.

Language: Английский

Citations

12
Solubility determination, correlation, solvent effect and thermodynamic properties of tolnaftate in ten mono-solvents and binary solvent systems from 283.15 K to 328.15 K DOI
Kejia Wang, Wei Zhang,

Yuanmo Ren

et al.

The Journal of Chemical Thermodynamics, Journal Year: 2025, Volume and Issue: unknown, P. 107468 - 107468

Published: Feb. 1, 2025

Language: Английский

Citations

1
PEGylated terpesomes of curcumin for prominent hepatoprotective activity: fabrication, optimization, biochemical analysis and in vivo evaluation DOI
Abdurrahman M. Fahmy,

Bander Balkhi,

Mohamed A. Sadek

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106876 - 106876

Published: April 1, 2025

Language: Английский

Citations

1
Terconazole loaded edge-activated hybrid elastosome for revamped corneal permeation in ocular mycosis: In-vitro characterization, statistical optimization, microbiological assessment, and in-vivo evaluation. DOI Creative Commons
Sadek Ahmed, Michael M. Farag, Heba Attia

et al.

International Journal of Pharmaceutics X, Journal Year: 2025, Volume and Issue: unknown, P. 100333 - 100333

Published: April 1, 2025

Herein, we investigated the preparation and characterization of Terconazole loaded edge-activated hybrid elastosome (TCN-EHE) adopting thin film hydration technique for treatment ocular mycosis. (TCN) is a broad spectrum antimycotic agent suffering from sparse aqueous solubility impeding its use in ophthalmic preparations. The scrutinized formulation variables namely X1: Surfactant: Edge activator ratio (SAA: EA), X2: Pluronic® L121 contribution (% total SAA) X3: EA concentration (%w/v) were optimized D-optimal design. Ten runs prepared characterized regarding their entrapment efficiency, particle size, polydispersity index zeta potential. An formula was generated, with high desirability, exhibited satisfactory nanoscaled size aligning TEM, plausible potential bi-phasic release pattern which not altered after short-term storage. TCN-EHE displayed 1.94-fold enhanced ex-vivo corneal permeation flux. Safety ratified through measured level, pH histopathological evaluation. In-vivo uptake visualized by confocal laser microscopy demonstrated 2.7-fold deeper penetration. Moreover, Superior antifungal activity has been displaying 37 % bigger zone inhibition, 8-fold lower minimum inhibitory fungal alongside significantly higher biofilm inhibition at all tested concentrations compared to TCN suspension. Conclusively, could prospect that might be revamped therapeutic alternative delivery poorly soluble agents combat

Language: Английский

Citations

1
ENHANCING QUALITY-BY-DESIGN THROUGH WEIGHTED GOAL PROGRAMMING: A CASE STUDY ON FORMULATION OF ULTRADEFORMABLE LIPOSOMES DOI

Sonia Valverde Cabeza,

Pedro Luis González Rodríguez, Marı́a Luisa González-Rodrı́guez

et al.

Drug Development and Industrial Pharmacy, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 28

Published: Feb. 24, 2025

Introduction Optimization of pharmaceutical formulations requires advanced tools to ensure quality, safety, and efficacy. Quality-by-Design (QbD), introduced by the FDA, emphasizes understanding controlling processes early in development. Advanced optimization methods, such as desirability, have surpassed traditional single-objective techniques. Others Weighted Goal Programming (WGP) offers unique advantages integrating decision-maker preferences, enabling balanced solutions for complex drug delivery systems. This study applies WGP optimize timolol-loaded nanoliposomes aligning with QbD principles.

Language: Английский

Citations

0