A comprehensive review on niosomes: novel manufacturing techniques, factors influencing formation, applications and recent advances DOI

Nida Arshad,

Farwa Shaheen,

Iqra Khan

et al.

International Journal of Polymeric Materials, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 18

Published: Nov. 18, 2024

A huge variety of drugs having varying therapeutic effects can be encapsulated into niosomes and delivered to patients in an efficient way. These nonionic vesicles form a double layer fluid media, enhancing bioavailability. Niosomes prepared using various methods such as the Reverse Phase Evaporation Technique, Ether Injection Method, Bubble Microfluidization, Hand Shaking Sonication, Multiple Membrane Extrusion Niosome Formation from Proniosomes. are used applications, including targeting bioactive substances, neoplasia, diagnostic imaging ophthalmic drug delivery system. Advancement will results development smart-stimuli niosomal system that inhibits ovarian cancer cells, MCF10-A cells by biofunctionalizing curcumin, with potential for more potent tumor-inhibitory effects. It also lead formation thermo-responsive Pluronic® L64 L64ox nanosilica substrate HER2-positive breast treatment. This review aims analyze novel manufacturing techniques, factors influencing formation, applications delivery, highlighting their stability, bioavailability, targeted advantages. explores recent advancements, responsive systems disease

Language: Английский

Niosome Preparation Techniques and Structure—An Illustrated Review DOI Creative Commons
Saeid Mezail Mawazi, Yi Ge, Riyanto Teguh Widodo

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(1), P. 67 - 67

Published: Jan. 6, 2025

A comprehensive review of recent research on niosomes was conducted using a mixed methodology, including searches in databases such as Scopus, PubMed, and Web Science (WoS). Articles were selected based relevance. The current examines the historical development focusing methods preparations contemporary strategies prospective advancements within realm drug delivery systems, highlighting innovative approaches across transdermal, oral, cellular delivery. This reported method new novel approach for preparation known ball milling (BM). technique allows precise manipulation size shape, leading to improvements release, encapsulation efficiency, uniformity compared traditional methods. Niosomes can serve carriers delivering various types drugs, hydrophobic, hydrophilic, amphiphilic. improves efficiency encapsulating different targeted particles, desired zeta potential. is achieved by specific charge-inducing agent targeting diseases. These efforts are crucial overcoming limitations unlocking full therapeutic potential modern medicine.

Language: Английский

Citations

3

Quantum Dot Research in Breast Cancer: Challenges and Prospects DOI Open Access
Hossein Omidian,

Renae L. Wilson,

Luigi X. Cubeddu

et al.

Materials, Journal Year: 2024, Volume and Issue: 17(9), P. 2152 - 2152

Published: May 4, 2024

The multifaceted role of quantum dots (QDs) in breast cancer research highlights significant advancements diagnostics, targeted therapy, and drug delivery systems. This comprehensive review addresses the development precise imaging techniques for early detection use QDs enhancing specificity therapeutic delivery, particularly challenging cases like triple-negative (TNBC). paper also discusses critical understanding QDs’ interactions with cells, offering insights into their potential inducing cytotoxic effects facilitating gene therapy. Limitations such as biocompatibility, toxicity concerns, transition from laboratory to clinical practice are critically analyzed. Future directions emphasize safer, non-toxic QD development, improved targeting mechanisms, integration personalized medicine, aiming overcome current challenges enhance management.

Language: Английский

Citations

6

Antibacterial and antibiofilm activities of selenium nanoparticles-antibiotic conjugates against anti-multidrug-resistant bacteria DOI

Dalal M. Ridha,

Mohammed J. Al-Awady,

Afrah Jawad Abd AL-Zwaid

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 658, P. 124214 - 124214

Published: May 8, 2024

Language: Английский

Citations

6

Innovative approaches in breast cancer therapy: repurposing nanocarriers for enhanced outcomes DOI

Sana Naaz Siddiqui,

Md. Faheem Haider, M.A. Rahman

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0

Niosomes as a Targeted Drug Delivery system in the Treatment of Breast Cancer: Preparation, Classification, and Mechanisms of Cellular Uptake DOI

Muneeb UrRahman,

Hafiz Rashid Hussain,

Huzaifa Akram

et al.

Journal of drug targeting, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 36

Published: Feb. 18, 2025

Breast cancer remains one of the significant health issues across globe, being diagnosed in millions women worldwide annually. Conventional therapeutic options have substantial adverse effects due to their non-specificity and limited drug bioavailability. Niosomes, novel delivery systems formed from non-ionic surfactants, with or without cholesterol charge-inducing agents, are used as treating BC. Their formulation by various methods enhances efficacy bioavailability minimizes side effects. Niosomal tamoxifen exhibits target enhanced stability, whereas docetaxel methotrexate show sustained controlled release, respectively.5-Fluorouracil, doxorubicin, paclitaxel, cyclophosphamide, epirubicin improved cytotoxic against BC when combined other agents. Furthermore, repurposed niosomal formulations anti-cancer drugs penetration, reduced tumor volume, significantly anti-tumor effect. This review article focuses on composition niosomes application treatment then examines how could contribute research.

Language: Английский

Citations

0

A comprehensive review on niosomes: novel manufacturing techniques, factors influencing formation, applications and recent advances DOI

Nida Arshad,

Farwa Shaheen,

Iqra Khan

et al.

International Journal of Polymeric Materials, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 18

Published: Nov. 18, 2024

A huge variety of drugs having varying therapeutic effects can be encapsulated into niosomes and delivered to patients in an efficient way. These nonionic vesicles form a double layer fluid media, enhancing bioavailability. Niosomes prepared using various methods such as the Reverse Phase Evaporation Technique, Ether Injection Method, Bubble Microfluidization, Hand Shaking Sonication, Multiple Membrane Extrusion Niosome Formation from Proniosomes. are used applications, including targeting bioactive substances, neoplasia, diagnostic imaging ophthalmic drug delivery system. Advancement will results development smart-stimuli niosomal system that inhibits ovarian cancer cells, MCF10-A cells by biofunctionalizing curcumin, with potential for more potent tumor-inhibitory effects. It also lead formation thermo-responsive Pluronic® L64 L64ox nanosilica substrate HER2-positive breast treatment. This review aims analyze novel manufacturing techniques, factors influencing formation, applications delivery, highlighting their stability, bioavailability, targeted advantages. explores recent advancements, responsive systems disease

Language: Английский

Citations

2