Oxeiptosis gene expression profiling identified TCN1 as a prognostic factor for breast cancer DOI
Yimin Zhu,

Lingyu Zhang,

Di Zeng

et al.

ONCOLOGIE, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 29, 2024

Language: Английский

Biomarker-driven molecular imaging probes in radiotherapy DOI Creative Commons
Haonan Li, Qiyong Gong, Kui Luo

et al.

Theranostics, Journal Year: 2024, Volume and Issue: 14(10), P. 4127 - 4146

Published: Jan. 1, 2024

Biomarker-driven molecular imaging has emerged as an integral part of cancer precision radiotherapy. The use probes, including nanoprobes, have been explored in radiotherapy to precisely and noninvasively monitor spatiotemporal distribution biomarkers, potentially revealing tumor-killing mechanisms therapy-induced adverse effects during radiation treatment.

Language: Английский

Citations

78
Tumor Microenvironment Dynamics of Triple-Negative Breast Cancer Under Radiation Therapy DOI Open Access

Suryakant Niture,

Subhajit Ghosh, Jerry J. Jaboin

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2795 - 2795

Published: March 20, 2025

Triple-negative breast cancer (TNBC) is an aggressive subtype of characterized by the absence estrogen receptors (ER), progesterone (PR), and HER2 expression. While TNBC relatively less common, accounting for only 10–15% initial diagnosis, due to its nature, it carries a worse prognosis in comparison hormone receptor-positive counterparts. Despite significant advancements screening, treatment cancer, remains important public health burden. Following with chemotherapy, surgery, radiation, over 40% patients experience relapse within 3 years achieve least benefit from post-mastectomy radiation. The tumor microenvironment environment (TME) pivotal initiation, progression, immune evasion, resistance, prognosis. TME complex network that consists cells, non-immune soluble factors located region adjacent modulates therapeutic response differentially between TNBC. mechanisms underlying radiation resistance remain unclear, immunosuppressive has been implicated chemotherapeutic resistance. Radiation therapy (RT) known alter TME; however, changes elicited are poorly date, whether these contribute unknown. This review delves into distinct characteristics TME, explores how RT influences dynamics, examines radiosensitization, radioresistance, responses.

Language: Английский

Citations

0
Radioligand therapy in metastatic breast Cancer: Harnessing precision oncology DOI Creative Commons
Federica Giugliano,

Elisa Giordano,

Laura Gilardi

et al.

Cancer Treatment Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102940 - 102940

Published: April 1, 2025

Radioligand therapy (RLT) represents a promising advancement in precision oncology and enables the targeted delivery of radiation to cancer cells. This approach has shown success other tumor types, such as prostate neuroendocrine tumors. Its potential metastatic breast (mBC) is currently under investigation. review discusses RLT mechanism action, therapeutic potential, integration into existing landscape mBC. While clinical trials have results, challenges remain regarding target heterogeneity, implementation, optimizing treatment strategies. Further research essential integrate practice improve patient outcomes fully.

Language: Английский

Citations

0
Transcription Impairment of TMEM208 by ZBTB14 Suppresses Breast cancer Radiotherapy Resistance DOI Creative Commons
Li Yan, Lili Liang

Journal of Mammary Gland Biology and Neoplasia, Journal Year: 2024, Volume and Issue: 29(1)

Published: Dec. 1, 2024

Language: Английский

Citations

0
Oxeiptosis gene expression profiling identified TCN1 as a prognostic factor for breast cancer DOI
Yimin Zhu,

Lingyu Zhang,

Di Zeng

et al.

ONCOLOGIE, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 29, 2024

Language: Английский

Citations

0