Immunity & Ageing,
Journal Year:
2023,
Volume and Issue:
20(1)
Published: Sept. 13, 2023
Abstract
Background
Obesity
is
associated
with
chronic
low-grade
inflammation,
which
underpinned
by
the
presence
of
elevated
levels
circulating
proinflammatory
cytokines
in
obese
individuals.
Due
to
close
relationship
between
adipose
tissue
and
immune
system,
it
can
be
speculated
that
accumulation
fat
may
influence
frequency
phenotype
lymphocyte
populations.
The
aim
our
study
was
investigate
whether
body
distribution
B
composition
peripheral
blood.
We
examined
association
visceral
(VAT)
total
(TBF)
frequencies
B-cell
subsets
238
subjects
over
a
period
up
one
year
using
random
intercept
models.
were
determined
fluorescence-based
flow
cytometry.
Results
Inverse
associations
found
measurements
plasma
blasts,
memory
cells,
IgM
−
IgD
cells.
VAT,
but
not
TBF,
positively
naive
CD19
In
analyses,
both
VAT
TBF
showed
positive
only
Conclusions
conclusion,
seems
lower
proportion
antibody-secreting
blasts
cells
an
increasing
amount
partially
anergic,
Immunological Reviews,
Journal Year:
2024,
Volume and Issue:
324(1), P. 78 - 94
Published: May 8, 2024
Summary
It
is
now
widely
understood
that
visceral
adipose
tissue
(VAT)
a
highly
active
and
dynamic
organ,
with
many
functions
beyond
lipid
accumulation
storage.
In
this
review,
we
discuss
the
immunological
role
of
tissue,
underpinned
by
presence
fat‐associated
lymphoid
clusters
(FALCs).
FALC's
distinctive
structure
stromal
cell
composition
support
very
different
immune
mix
to
found
in
classical
secondary
organs,
which
underlies
their
unique
filtration,
surveillance,
innate‐like
responses,
adaptive
immunity
within
serous
cavities.
FALCs
are
important
B
hubs
providing
B1
cell‐mediated
frontline
protection
against
infection
supporting
B2
cell‐adaptative
responses.
Beyond
these
beneficial
responses
orchestrated
FALCs,
cells
VAT
play
homeostatic
role.
Dysregulation
during
obesity
aging
leads
chronic
pathological
“metabolic
inflammation”,
contributes
development
cardiometabolic
diseases.
Here,
examine
emerging
complex
homeostasis
metabolic
complications
obesity,
highlighting
potential
emphasize
areas
where
further
research
needed.
Molecular Metabolism,
Journal Year:
2024,
Volume and Issue:
87, P. 101981 - 101981
Published: July 4, 2024
The
metabolism
of
different
cells
within
the
same
microenvironment
can
differ
and
dictate
physiological
or
pathological
adaptions.
Current
single-cell
analysis
methods
are
not
label-free.
Current Issues in Molecular Biology,
Journal Year:
2023,
Volume and Issue:
45(8), P. 6667 - 6681
Published: Aug. 13, 2023
B
and
T
lymphocytes
demonstrate
important
alterations
in
patients
with
systemic
lupus
erythematous
(SLE),
a
significant
upregulation
of
double
negative
(DN)
cells.
The
aim
this
study
was
to
evaluate
the
correlation
cell
immunity
changes
distinct
B-cell-pattern
SLE.
In
present
study,
flow
cytometry
performed
30
remission
SLE
31
healthy
controls
detect
DN
cells
(CD19+IgD-CD27-)
wide
range
lymphocyte
subpopulations
based
on
presence
CD45RA,
CCR7,
CD31,
CD28,
CD57,
defined
as
naive,
memory,
advanced
differentiated/senescent
Both
were
significantly
reduced
patients.
However,
percentage
increased
compared
HC
(12.9
(2.3–74.2)
vs.
8
(1.7–35),
p
=
0.04).
distribution
CD4
CD8
demonstrated
shift
differentiated
subsets.
population
had
positive
most
early
lymphocytes,
CD4CD31+,
CD4CD45RA+CD28+,
CD4CD45RA+CD57-,
CD4CD45RA-CD57-,
CD4CD28+CD57-,
CD4CD28+CD57+,
CM,
CD31+,
NAÏVE,
CD8CD45RA-CD57-,
CD8CD28+CD57-,
CD8CD28+CD57+.
Multiple
regression
analysis
revealed
CD8CD28+CD57-
independent
parameters
contributing
cells,
adjusted
R2
0.534
<
0.0001.
predominance
is
closely
associated
subsets,
indicating
potential
causality
role
activation.
Immunity & Ageing,
Journal Year:
2023,
Volume and Issue:
20(1)
Published: Sept. 13, 2023
Abstract
Background
Obesity
is
associated
with
chronic
low-grade
inflammation,
which
underpinned
by
the
presence
of
elevated
levels
circulating
proinflammatory
cytokines
in
obese
individuals.
Due
to
close
relationship
between
adipose
tissue
and
immune
system,
it
can
be
speculated
that
accumulation
fat
may
influence
frequency
phenotype
lymphocyte
populations.
The
aim
our
study
was
investigate
whether
body
distribution
B
composition
peripheral
blood.
We
examined
association
visceral
(VAT)
total
(TBF)
frequencies
B-cell
subsets
238
subjects
over
a
period
up
one
year
using
random
intercept
models.
were
determined
fluorescence-based
flow
cytometry.
Results
Inverse
associations
found
measurements
plasma
blasts,
memory
cells,
IgM
−
IgD
cells.
VAT,
but
not
TBF,
positively
naive
CD19
In
analyses,
both
VAT
TBF
showed
positive
only
Conclusions
conclusion,
seems
lower
proportion
antibody-secreting
blasts
cells
an
increasing
amount
partially
anergic,
