Cell, Journal Year: 2014, Volume and Issue: 157(5), P. 1189 - 1202
Published: May 1, 2014
Language: Английский
Cell Death and Differentiation, Journal Year: 2018, Volume and Issue: 25(3), P. 486 - 541
Published: Jan. 23, 2018
Over the past decade, Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for definition and interpretation of cell death from morphological, biochemical, functional perspectives. Since field continues to expand novel mechanisms that orchestrate multiple pathways are unveiled, we propose an updated classification subroutines focusing mechanistic essential (as opposed correlative dispensable) aspects process. As provide molecularly oriented definitions terms including intrinsic apoptosis, extrinsic mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic death, NETotic lysosome-dependent autophagy-dependent immunogenic cellular senescence, mitotic catastrophe, discuss utility neologisms refer highly specialized instances these processes. The mission NCCD is a widely accepted nomenclature in support continued development field.
Language: Английский
Citations
5383
Nature reviews. Immunology, Journal Year: 2013, Volume and Issue: 13(6), P. 397 - 411
Published: May 24, 2013
Language: Английский
Citations
2666
Nature, Journal Year: 2015, Volume and Issue: 517(7534), P. 311 - 320
Published: Jan. 13, 2015
Language: Английский
Citations
1832
Nature Reviews Molecular Cell Biology, Journal Year: 2014, Volume and Issue: 15(2), P. 135 - 147
Published: Jan. 23, 2014
Language: Английский
Citations
1571
Immunity, Journal Year: 2013, Volume and Issue: 38(2), P. 209 - 223
Published: Feb. 1, 2013
Language: Английский
Citations
1270
Immunity, Journal Year: 2013, Volume and Issue: 39(3), P. 443 - 453
Published: Sept. 1, 2013
Language: Английский
Citations
1102
New England Journal of Medicine, Journal Year: 2014, Volume and Issue: 370(5), P. 455 - 465
Published: Jan. 29, 2014
Cell death is regulated by a variety of mechanisms. This review focuses on one the more recently identified forms programmed cell death, necroptosis, and its role in normal disease states. pathway provides new targets for therapeutic intervention.
Language: Английский
Citations
985
Immunological Reviews, Journal Year: 2015, Volume and Issue: 265(1), P. 6 - 21
Published: April 16, 2015
Summary Inflammasome biology is one of the most exciting and rapidly growing areas in immunology. Over past 10 years, inflammasomes have been recognized for their roles host defense against invading pathogens development cancer, auto‐inflammatory, metabolic, neurodegenerative diseases. Assembly an inflammasome complex requires cytosolic sensing pathogen‐associated molecular patterns or danger‐associated by a nucleotide‐binding domain leucine‐rich repeat receptor ( NLR ) absent melanoma 2 (AIM2)‐like receptors ALR ). s engage caspase‐1, cases requiring adapter protein apoptosis‐associated speck‐like containing CARD ASC ), to catalyze proteolytic cleavage pro‐interleukin‐1β (pro‐ IL ‐1β) pro‐ ‐18 drive pyroptosis. Recent studies indicate that caspase‐8, caspase‐11, ‐1R–associated kinases IRAK receptor‐interacting RIP contribute functions. In addition, post‐translational modifications, including ubiquitination, deubiquitination, phosphorylation, degradation control almost every aspect activities. Genetic mutations NLRP 1, 3, NLRC 4, AIM are linked with auto‐inflammatory diseases, enterocolitis, cancer. Overall, these findings transform our understanding basic clinical relevance inflammasomes. this review, we provide overview latest research discuss how activities govern health disease.
Language: Английский
Citations
953
Cellular and Molecular Immunology, Journal Year: 2021, Volume and Issue: 18(9), P. 2114 - 2127
Published: July 28, 2021
Language: Английский
Citations
952
Nature reviews. Immunology, Journal Year: 2017, Volume and Issue: 17(3), P. 151 - 164
Published: Jan. 31, 2017
Language: Английский
Citations
912