Translational research, Journal Year: 2016, Volume and Issue: 179, P. 204 - 222
Published: Aug. 15, 2016
Language: Английский
Frontiers in Cellular and Infection Microbiology, Journal Year: 2018, Volume and Issue: 8
Published: Feb. 5, 2018
The gut microbiota influences the health of host, especially with regard to immune homeostasis and intestinal response. In addition serving as a nutrient enhancer, L-tryptophan (Trp) plays crucial roles in balance between tolerance maintenance. Recent discoveries have underscored that changes modulate host system by modulating Trp metabolism. Moreover, Trp, endogenous metabolites (kynurenines, serotonin melatonin), bacterial (indole, indolic acid, skatole, tryptamine) profound effects on microbial composition, metabolism, host's system, host-microbiome interface, system–intestinal interactions. aryl hydrocarbon receptor (AhR) mediates regulation immunity (as ligands AhR), which is beneficial for homeostasis. Among metabolites, AhR consist including kynurenine, kynurenic xanthurenic cinnabarinic indole, indole propionic acetic tryptamine. Additional factors, such aging, stress, probiotics, diseases (spondyloarthritis, irritable bowel syndrome, inflammatory disease, colorectal cancer), are associated variability can influence Trp–microbiome–immune interactions also play regulating immunity. This review clarifies how regulates metabolism identifies underlying molecular mechanisms these Increased mechanistic insight into modulates through may allow identification innovative microbiota-based diagnostics, well appropriate nutritional supplementation prevent or alleviate inflammation. this provides new regarding comprehensive analyses targeted (including metabolites) essential experimental preciseness, cannot be neglected, explain contradictory results literature.
Language: Английский
Citations
1021
Frontiers in Microbiology, Journal Year: 2018, Volume and Issue: 9
Published: Aug. 14, 2018
Interest toward the human microbiome, particularly gut microbiome has flourished in recent decades owing to rapidly advancing sequence-based screening and humanized gnotobiotic model interrogating dynamic operations of commensal microbiota. Although this field is still at a very preliminary stage, whereby functional properties complex remain less understood, several promising findings have been documented exhibit great potential revolutionizing disease etiology medical treatments. In review, interactions between microbiota host focused on, provide an overview role their unique metabolites conferring protection against invading pathogen, regulation diverse physiological functions including metabolism, development homeostasis immunity nervous system. We elaborate on how microbial imbalance (dysbiosis) may lead dysfunction machineries, thereby contributing pathogenesis and/or progression broad spectrum diseases. Some most notable diseases namely Clostridium difficile infection (infectious disease), inflammatory bowel (intestinal immune-mediated celiac (multisystemic autoimmune disorder), obesity (metabolic colorectal cancer, autism disorder (neuropsychiatric disorder) discussed delineated along with findings. Novel therapies derived from studies such as fecal transplantation, probiotic prebiotics target associated reviewed introduce idea certain symptoms can be ameliorated through dysbiosis correction, thus revealing new scientific approach treatment. Toward end research gaps limitations described suggested future overcome current lacunae. Despite ongoing debate whether plays above-mentioned diseases, we gathered evidence showing potentially far more link beyond unidirectional cause-and-effect relationship them.
Language: Английский
Citations
950
Antonie van Leeuwenhoek, Journal Year: 2020, Volume and Issue: 113(12), P. 2019 - 2040
Published: Nov. 2, 2020
Language: Английский
Citations
917
Proceedings of the National Academy of Sciences, Journal Year: 2014, Volume and Issue: 111(42)
Published: Oct. 6, 2014
Significance Alcohol-dependent subjects frequently develop emotional symptoms that contribute to the persistence of alcohol drinking. These are also characterized by gastrointestinal disturbances. In this study, we showed alcohol-dependent with altered intestinal permeability had gut-microbiota composition and activity remained high scores depression, anxiety, craving after a short-term detoxification program. results consistent existence gut–brain axis in dependence, which gut microbiota could alter gut-barrier function influence behavior dependence. Therefore, study opens previously unidentified field research for treatment management targeting microbiota.
Language: Английский
Citations
834
The Journal of Experimental Medicine, Journal Year: 2018, Volume and Issue: 216(1), P. 20 - 40
Published: Oct. 15, 2018
Over the past decade, our view of human-associated microbes has expanded beyond that a few species toward an appreciation diverse and niche-specialized microbial communities develop in human host with chronological age. The largest reservoir exists distal gastrointestinal tract, both lumen, where facilitate primary secondary metabolism, on mucosal surfaces, they interact immune cell populations. While local microbial-driven immunomodulation gut is well described, more recent studies have demonstrated role for microbiome influencing remote organs hematopoietic function. Unsurprisingly, therefore, perturbation to composition function microbiota been associated chronic diseases ranging from inflammatory metabolic conditions neurological, cardiovascular, respiratory illnesses. Considerable effort currently focused understanding natural history development humans context health outcomes, parallel improving knowledge microbiome-host molecular interactions. These efforts ultimately aim effective approaches rehabilitate perturbed ecosystems as means restore or prevent disease. This review details modulating focus discusses strategies manipulating management prevention conditions.
Language: Английский
Citations
754
Cell Metabolism, Journal Year: 2017, Volume and Issue: 26(1), P. 110 - 130
Published: June 15, 2017
Language: Английский
Citations
723
Cell Host & Microbe, Journal Year: 2017, Volume and Issue: 22(1), P. 25 - 37.e6
Published: July 1, 2017
Language: Английский
Citations
711
Nature Reviews Microbiology, Journal Year: 2019, Volume and Issue: 17(12), P. 742 - 753
Published: Sept. 20, 2019
Language: Английский
Citations
702
Nature Reviews Microbiology, Journal Year: 2019, Volume and Issue: 17(8), P. 497 - 511
Published: June 27, 2019
Language: Английский
Citations
697
BMC Immunology, Journal Year: 2017, Volume and Issue: 18(1)
Published: Jan. 6, 2017
A vast diversity of microbes colonizes in the human gastrointestinal tract, referred to intestinal microbiota. Microbiota and products thereof are indispensable for shaping development function host innate immune system, thereby exerting multifaceted impacts gut health. This paper reviews effects on immunity microbe-derived nucleic acids, microbial metabolites, as well involvement commensals homeostasis. We focus recent findings with an intention illuminate mechanisms by which microbiota interacting immunity, scrutinize imbalanced (dysbiosis) lead autoimmune disorders including inflammatory bowel disease (IBD), Type 1 diabetes (T1D) systemic syndromes such rheumatoid arthritis (RA). In addition their well-recognized benefits occupation ecological niches competition pathogens, commensal bacteria have been shown strengthen barrier exert immunomodulatory actions within beyond. It has realized that impaired not only contribute diseases but also inextricably linked metabolic even brain dysfunction. better understanding mutual interactions would shed light our endeavors prevention broaden path discovery intervention targets treatment.
Language: Английский
Citations
638