Trends in cancer,
Journal Year:
2020,
Volume and Issue:
6(3), P. 192 - 204
Published: Feb. 7, 2020
The
collection
of
microbes
that
live
in
and
on
the
human
body
-
microbiome
can
impact
cancer
initiation,
progression,
response
to
therapy,
including
immunotherapy.
mechanisms
by
which
microbiomes
cancers
yield
new
diagnostics
treatments,
but
much
remains
unknown.
interactions
between
microbes,
diet,
host
factors,
drugs,
cell-cell
within
itself
likely
involve
intricate
feedbacks,
no
single
component
explain
all
behavior
system.
Understanding
role
host-associated
microbial
communities
systems
will
require
a
multidisciplinary
approach
combining
ecology,
immunology,
cell
biology,
computational
biology
approach.
Cell Research,
Journal Year:
2020,
Volume and Issue:
30(6), P. 492 - 506
Published: May 20, 2020
Abstract
The
interplay
between
the
commensal
microbiota
and
mammalian
immune
system
development
function
includes
multifold
interactions
in
homeostasis
disease.
microbiome
plays
critical
roles
training
of
major
components
host’s
innate
adaptive
system,
while
orchestrates
maintenance
key
features
host-microbe
symbiosis.
In
a
genetically
susceptible
host,
imbalances
microbiota-immunity
under
defined
environmental
contexts
are
believed
to
contribute
pathogenesis
multitude
immune-mediated
disorders.
Here,
we
review
microbiome-immunity
crosstalk
their
health
disease,
providing
examples
molecular
mechanisms
orchestrating
these
intestine
extra-intestinal
organs.
We
highlight
aspects
current
knowledge,
challenges
limitations
achieving
causal
understanding
host
immune-microbiome
interactions,
as
well
impact
on
diseases,
discuss
how
insights
may
translate
towards
future
microbiome-targeted
therapeutic
interventions.
Nature Communications,
Journal Year:
2021,
Volume and Issue:
12(1)
Published: July 1, 2021
Abstract
Emerging
data
demonstrate
that
the
activity
of
immune
cells
can
be
modulated
by
microbial
molecules.
Here,
we
show
short-chain
fatty
acids
(SCFAs)
pentanoate
and
butyrate
enhance
anti-tumor
cytotoxic
T
lymphocytes
(CTLs)
chimeric
antigen
receptor
(CAR)
through
metabolic
epigenetic
reprograming.
We
in
vitro
treatment
CTLs
CAR
with
increases
function
mTOR
as
a
central
cellular
sensor,
inhibits
class
I
histone
deacetylase
activity.
This
reprogramming
results
elevated
production
effector
molecules
such
CD25,
IFN-γ
TNF-α,
significantly
enhances
antigen-specific
ROR1-targeting
syngeneic
murine
melanoma
pancreatic
cancer
models.
Our
shed
light
onto
may
used
for
enhancing
immunity.
Collectively,
identify
two
SCFAs
therapeutic
utility
context
immunotherapy.
Internal and Emergency Medicine,
Journal Year:
2023,
Volume and Issue:
19(2), P. 275 - 293
Published: July 28, 2023
Abstract
The
intestine
is
the
largest
interface
between
internal
body
and
external
environment.
intestinal
barrier
a
dynamic
system
influenced
by
composition
of
microbiome
activity
intercellular
connections,
regulated
hormones,
dietary
components,
inflammatory
mediators,
enteric
nervous
(ENS).
Over
years,
it
has
become
increasingly
evident
that
maintaining
stable
crucial
to
prevent
various
potentially
harmful
substances
pathogens
from
entering
Disruption
referred
as
'leaky
gut'
or
leaky
gut
wall
syndrome
seems
be
characterized
release
bacterial
metabolites
endotoxins,
such
lipopolysaccharide
(LPS),
into
circulation.
This
condition,
mainly
caused
infections,
oxidative
stress,
high-fat
diet,
exposure
alcohol
chronic
allergens,
dysbiosis,
appear
highly
connected
with
development
and/or
progression
several
metabolic
autoimmune
systemic
diseases,
including
obesity,
non-alcoholic
fatty
liver
disease
(NAFLD),
neurodegeneration,
cardiovascular
disease,
bowel
type
1
diabetes
mellitus
(T1D).
In
this
review,
starting
description
mechanisms
enable
homeostasis
analyzing
relationship
complex
ecosystem
pathological
conditions,
we
explore
role
in
driving
inflammation,
also
shedding
light
on
current
future
therapeutic
interventions.
Frontiers in Cellular and Infection Microbiology,
Journal Year:
2021,
Volume and Issue:
11
Published: Nov. 22, 2021
Roseburia
intestinalis
is
an
anaerobic,
Gram-positive,
slightly
curved
rod-shaped
flagellated
bacterium
that
produces
butyrate
in
the
colon.
R.
has
been
shown
to
prevent
intestinal
inflammation
and
maintain
energy
homeostasis
by
producing
metabolites.
Evidence
shows
this
contributes
various
diseases,
such
as
inflammatory
bowel
disease,
type
2
diabetes
mellitus,
antiphospholipid
syndrome,
atherosclerosis.
This
review
reveals
potential
therapeutic
role
of
human
diseases.
Patients
with
disease
exhibit
significant
changes
abundance,
they
may
benefit
a
lot
from
modulations
targeting
.
The
data
reviewed
here
demonstrate
plays
its
regulating
barrier
homeostasis,
immune
cells,
cytokine
release
through
metabolite
butyrate,
flagellin
other.
Recent
advancements
application
primary
culture
technology,
omics,
single-cell
sequencing,
metabonomics
technology
have
improved
research
on
revealed
benefits
health
treatment.
