Frontiers in Medicine,
Journal Year:
2022,
Volume and Issue:
9
Published: March 31, 2022
Over
the
last
10
years,
there
has
been
a
growing
interest
in
relationship
between
gut
microbiota,
brain,
and
neurologic-associated
affections.
As
multiple
preclinical
clinical
research
studies
highlight
microbiota’s
potential
to
modulate
general
state
of
health
state,
it
goes
without
saying
that
microbiota
plays
significant
role
neurogenesis,
mental
cognitive
development,
emotions,
behaviors,
progression
neuropsychiatric
illnesses.
Gut
produces
important
biologic
products
that,
through
gut-brain
axis,
are
directly
connected
with
appearance
evolution
neurological
psychiatric
disorders
such
as
depression,
anxiety,
bipolar
disorder,
autism,
schizophrenia,
Parkinson’s
disease,
Alzheimer’s
dementia,
sclerosis,
epilepsy.
This
study
reviews
recent
on
link
microbiome’s
shaping
development
most
common
Moreover,
special
attention
is
paid
use
probiotic
formulations
non-invasive
therapeutic
opportunity
for
prevention
management
neuropsychiatric-associated
Cells,
Journal Year:
2023,
Volume and Issue:
12(1), P. 184 - 184
Published: Jan. 2, 2023
Immune
cells
and
commensal
microbes
in
the
human
intestine
constantly
communicate
with
react
to
each
other
a
stable
environment
order
maintain
healthy
immune
activities.
system-microbiota
cross-talk
relies
on
complex
network
of
pathways
that
sustain
balance
between
tolerance
immunogenicity.
Probiotic
bacteria
can
interact
stimulate
intestinal
microflora
modulate
specific
functions
homeostasis.
Growing
evidence
shows
probiotic
present
important
health-promoting
immunomodulatory
properties.
Thus,
use
probiotics
might
represent
promising
approach
for
improving
system
So
far,
few
studies
have
been
reported
beneficial
modulatory
effect
probiotics.
However,
many
others,
which
are
mainly
focused
their
metabolic/nutritional
properties,
published.
Therefore,
mechanisms
behind
interaction
host
only
partially
described.
The
review
aims
collect
summarize
most
recent
scientific
results
resulting
implications
how
improve
functions.
Hence,
description
currently
known
is
provided.
Frontiers in Immunology,
Journal Year:
2021,
Volume and Issue:
12
Published: May 26, 2021
The
diverse
and
dynamic
microbial
community
of
the
human
gastrointestinal
tract
plays
a
vital
role
in
health,
with
gut
microbiota
supporting
development
function
immune
barrier.
Crosstalk
between
microbiota-gut
epithelium
system
determine
individual
health
status,
any
crosstalk
disturbance
may
lead
to
chronic
intestinal
conditions,
such
as
inflammatory
bowel
diseases
(IBD)
celiac
disease.
Microbiota-derived
metabolites
are
crucial
mediators
host-microbial
interactions.
Some
beneficially
affect
host
physiology
short-chain
fatty
acids
(SCFAs)
secondary
bile
acids.
Also,
tryptophan
catabolites
responses,
through
binding
aryl
hydrocarbon
receptor
(AhR).
AhR
is
abundantly
present
at
mucosal
surfaces
when
activated
enhances
epithelial
barrier
well
regulatory
responses.
Exogenous
diet-derived
indoles
(tryptophan)
major
source
endogenous
ligand
precursors
together
SCFAs
regulate
inflammation
by
lowering
stress
immunity,
IBD,
expression
downregulated
metabolites.
Here,
we
an
overview
microbiota-epithelium-
immunity
review
how
microbial-derived
contribute
homeostasis.
discuss
therapeutic
potential
bacterial
for
IBD
disease
essential
dietary
components
fibers
systemic
Nutrients,
Journal Year:
2021,
Volume and Issue:
13(2), P. 699 - 699
Published: Feb. 22, 2021
The
most
prevalent
diseases
of
our
time,
non-communicable
(NCDs)
(including
obesity,
type
2
diabetes,
cardiovascular
and
some
types
cancer)
are
rising
worldwide.
All
them
share
the
condition
an
“inflammatory
disorder”,
with
impaired
immune
functions
frequently
caused
or
accompanied
by
alterations
in
gut
microbiota.
These
multifactorial
maladies
also
have
common
malnutrition
related
to
physiopathology.
In
this
context,
diet
is
greatest
modulator
system–microbiota
crosstalk,
much
interest,
new
challenges,
arising
area
precision
nutrition
as
a
way
towards
treatment
prevention.
It
fact
that
westernized
(WD)
partly
responsible
for
increased
prevalence
NCDs,
negatively
affecting
both
microbiota
system.
Conversely,
other
nutritional
approaches,
such
Mediterranean
(MD),
positively
influence
system
microbiota,
proposed
not
only
potential
tool
clinical
management
different
disease
conditions,
but
prevention
health
promotion
globally.
Thus,
purpose
review
determine
regulatory
role
components
WD
MD
interplay,
order
understand,
create
awareness
of,
over
key
components.
Journal of Hematology & Oncology,
Journal Year:
2022,
Volume and Issue:
15(1)
Published: April 29, 2022
The
gut
microbiota
have
long
been
recognized
to
play
a
key
role
in
human
health
and
disease.
Currently,
several
lines
of
evidence
from
preclinical
clinical
research
gradually
established
that
the
can
modulate
antitumor
immunity
affect
efficacy
cancer
immunotherapies,
especially
immune
checkpoint
inhibitors
(ICIs).
Deciphering
underlying
mechanisms
reveals
reprogram
tumor
microenvironment
(TME)
by
engaging
innate
and/or
adaptive
cells.
Notably,
one
primary
modes
which
is
means
metabolites,
are
small
molecules
could
spread
their
initial
location
impact
local
systemic
response
promote
ICI
efficiency.
Mechanistic
exploration
provides
novel
insights
for
developing
rational
microbiota-based
therapeutic
strategies
manipulating
microbiota,
such
as
fecal
transplantation
(FMT),
probiotics,
engineered
microbiomes,
specific
microbial
augment
advance
age
utilization
precision
medicine.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Feb. 16, 2024
Abstract
The
human
gastrointestinal
tract
is
populated
with
a
diverse
microbial
community.
vast
genetic
and
metabolic
potential
of
the
gut
microbiome
underpins
its
ubiquity
in
nearly
every
aspect
biology,
including
health
maintenance,
development,
aging,
disease.
advent
new
sequencing
technologies
culture-independent
methods
has
allowed
researchers
to
move
beyond
correlative
studies
toward
mechanistic
explorations
shed
light
on
microbiome–host
interactions.
Evidence
unveiled
bidirectional
communication
between
central
nervous
system,
referred
as
“microbiota–gut–brain
axis”.
microbiota–gut–brain
axis
represents
an
important
regulator
glial
functions,
making
it
actionable
target
ameliorate
development
progression
neurodegenerative
diseases.
In
this
review,
we
discuss
mechanisms
As
provides
essential
cues
microglia,
astrocytes,
oligodendrocytes,
examine
communications
microbiota
these
cells
during
healthy
states
Subsequently,
diseases
using
metabolite-centric
approach,
while
also
examining
role
microbiota-related
neurotransmitters
hormones.
Next,
targeting
intestinal
barrier,
blood–brain
meninges,
peripheral
immune
system
counteract
dysfunction
neurodegeneration.
Finally,
conclude
by
assessing
pre-clinical
clinical
evidence
probiotics,
prebiotics,
fecal
transplantation
A
thorough
comprehension
will
foster
effective
therapeutic
interventions
for
management
