Pharmaceutical Patent Analyst, Journal Year: 2023, Volume and Issue: 12(6), P. 253 - 259
Published: Nov. 1, 2023
A snapshot of noteworthy recent developments in the patent literature relevance to pharmaceutical and medical research development.
Language: Английский
Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(9), P. 3834 - 3854
Published: June 3, 2024
Immunotherapy is an important cancer treatment method that offers hope for curing patients. While immunotherapy has achieved initial success, a major obstacle to its widespread adoption the inability benefit majority of The success or failure closely linked tumor's immune microenvironment. Recently, there been significant attention on strategies regulate tumor microenvironment in order stimulate anti-tumor responses immunotherapy. distinctive physical properties and design flexibility nanomedicines have extensively utilized target cells (including tumor-associated macrophages (TAMs), T cells, myeloid-derived suppressor (MDSCs), fibroblasts (TAFs)), offering promising advancements In this article, we reviewed aimed at targeting various focus models are based nanomedicines, with goal inducing enhancing improve It worth noting combining other treatments, such as chemotherapy, radiotherapy, photodynamic therapy, can maximize therapeutic effects. Finally, identified challenges nanotechnology-mediated needs overcome more effective nanosystems.
Language: Английский
Citations
16
Diseases, Journal Year: 2024, Volume and Issue: 12(3), P. 63 - 63
Published: March 21, 2024
Solute carrier (SLC) transporters constitute a vast superfamily of transmembrane proteins tasked with regulating the transport various substances such as metabolites, nutrients, ions, and drugs across cellular membranes. SLC exhibit coordinated expression patterns normal tissues, suggesting tightly regulated regulatory network governing functions. These are crucial for including carbohydrates, proteins, lipids, nucleic acids. However, during tumor development, metabolic changes drive an increased demand energy nutrients. Consequently, cells alter to meet their heightened nutrient requirements. Targeting SLCs through inhibition or activation presents promising therapeutic approach in cancer treatment. Certain also serve intriguing chemo-sensitizing targets, modulating activity can potentially response chemotherapy. This review underscores significance progression potential both direct indirect targets therapy.
Language: Английский
Citations
13
Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(10), P. 4360 - 4377
Published: June 20, 2024
Purinergic signaling plays a causal role in the modulation of immune inflammatory response course psoriasis, but its regulatory mechanism remains unclear. As member purinoceptors, P2Y
Language: Английский
Citations
7
Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: 119, P. 878 - 897
Published: May 6, 2024
Metabolites and compounds derived from gut-associated bacteria can modulate numerous physiological processes in the host, including immunity behavior.Using a model of oral bacterial infection, we previously demonstrated that gut-derived peptidoglycan (PGN), an essential constituent cell envelope, influences female fruit fly egg-laying behavior by activating NF-κB cascade subset brain neurons.These findings underscore PGN as potential mediator communication between gut Drosophila, prompting further investigation into its impact on all cells.Through high-resolution mass spectrometry, now show fragments produced rapidly reach central nervous system.In Addition, employing combination whole-genome transcriptome analyses, comprehensive genetic assays, reporter gene systems, reveal infection triggers dose-dependent immune response perineurial glia, forming continuous outer layer blood-brain barrier.Furthermore, demonstrate persistent PGN-dependent activation glial cells correlates with reduction lifespan early neurological decline.Overall, our establish critical gut-immune-brain axis Drosophila.
Language: Английский
Citations
5
Journal of Investigative Dermatology, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 1, 2025
Language: Английский
Citations
0
Molecular Diagnosis & Therapy, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(18), P. 14390 - 14390
Published: Sept. 21, 2023
Psoriasis is an incurable skin disease that develops in about two-thirds of patients before the age 40 and requires lifelong treatment; its pathological mechanisms have not been fully elucidated. The core process psoriasis epidermal thickening caused by excessive proliferation keratinocytes, which similar to key feature cancer; malignant cancer cells causes tumor enlargement, suggesting there a certain degree commonality between cancer. This article reviews are common cancer, including interaction cell abnormal immune microenvironment, metabolic reprogramming, epigenetic reprogramming. In addition, therapeutic agents drug targets Thus, share mechanisms–drug targets–therapeutic framework. On this basis, it proposed investigating from perspective beneficial enriching research strategies related psoriasis.
Language: Английский
Citations
7
Chemical Communications, Journal Year: 2024, Volume and Issue: 60(16), P. 2212 - 2215
Published: Jan. 1, 2024
To further understand the specificity of muramyl dipeptide (MDP) sensing by NOD2, we evaluated compatibility synthetic MDP analogues for cellular uptake and NAGK phosphorylation, pre-requisite steps intracellular NOD2 activation.
Language: Английский
Citations
2
Cutis, Journal Year: 2024, Volume and Issue: 113(2)
Published: Feb. 1, 2024
Psoriasis is a chronic heterogeneous condition with multiple available treatment options that have resulted in dramatic disease improvements for patients. IL-23/IL-17 signaling the central immune pathway driving psoriasis, though recent research has uncovered other key contributing signals such as IL-17C, IL-17F, IL-36, and tyrosine kinase 2 (TYK2). Novel therapeutic targets inhibiting these cytokines expanded our understanding of pathogenesis psoriasis. critical development epidermal hyperplasia mature psoriatic plaque susceptible individuals. Increased IL-17 IL-23 expression works synergistically cytokines, IL-12, IL-22, tumor necrosis factor (TNF), interferon (IFN), to help create self-sustaining, feed-forward circuit keratinocytes, which contributes chronicity disease. This clinical review highlights discoveries immunopathogenesis psoriasis summarizes new antipsoriasis therapies targeting aryl hydrocarbon receptors (AHRs), phosphodiesterase 4 (PDE4), TYK2 signaling. Despite success continued needed further advance shape management strategies.
Language: Английский
Citations
2
Innate Immunity, Journal Year: 2023, Volume and Issue: 29(8), P. 186 - 200
Published: Oct. 13, 2023
NOD1 and NOD2 sense small bacterial peptidoglycan fragments, often called muropeptides, that access the cytosol. These muropeptides include iE-DAP MDP, minimal agonists for NOD2, respectively. Here, we synthesized validated alkyne-modified iE-DAP-Alk MDP-Alk, use in click-chemistry reactions. While it has long been known many cell types respond to extracellular exposure is unclear how these innate immune activators their cytosolic receptors, NOD2. The subcellular trafficking transport mechanisms by which receptors are a major gap our understanding of critical host responses. click-chemistry-enabled developed here will be particularly powerful decipher underlying biology biochemistry sensing.
Language: Английский
Citations
4