Metabolic rewiring and communication in cancer immunity DOI Creative Commons
Nicole M. Chapman, Hongbo Chi

Cell chemical biology, Journal Year: 2024, Volume and Issue: 31(5), P. 862 - 883

Published: Feb. 29, 2024

The immune system shapes tumor development and progression. Although immunotherapy has transformed cancer treatment, its overall efficacy remains limited, underscoring the need to uncover mechanisms improve therapeutic effects. Metabolism-associated processes, including intracellular metabolic reprogramming intercellular crosstalk, are emerging as instructive signals for anti-tumor immunity. Here, we first summarize roles of pathways in controlling cell function microenvironment. How communication regulates immunity, impact metabolites or nutrients on signaling events, also discussed. We then describe how targeting cells intratumoral via nutrient-based interventions may boost immunotherapies. Finally, conclude with discussions profiling functional perturbation methods activity cells, perspectives future directions. Uncovering rewiring microenvironment enable novel

Language: Английский

The cancer-immunity cycle: Indication, genotype, and immunotype DOI Creative Commons
Ira Mellman, Daniel S. Chen, Thomas Powles

et al.

Immunity, Journal Year: 2023, Volume and Issue: 56(10), P. 2188 - 2205

Published: Oct. 1, 2023

The cancer-immunity cycle provides a framework to understand the series of events that generate anti-cancer immune responses. It emphasizes iterative nature response where killing tumor cells by T initiates subsequent rounds antigen presentation and cell stimulation, maintaining active immunity adapting it evolution. Any step can become rate-limiting, rendering system unable control growth. Here, we update based on remarkable progress past decade. Understanding mechanism checkpoint inhibition has evolved, as our view dendritic in sustaining anti-tumor immunity. We additionally account for role microenvironment facilitating, not just suppressing, response, discuss importance considering tumor's immunological phenotype, "immunotype". While these new insights add some complexity cycle, they also provide targets research therapeutic intervention.

Language: Английский

Citations

355
Dendritic cells as orchestrators of anticancer immunity and immunotherapy DOI
Ignacio Heras‐Murillo, Irene Adán‐Barrientos, Miguel Á. Galán

et al.

Nature Reviews Clinical Oncology, Journal Year: 2024, Volume and Issue: 21(4), P. 257 - 277

Published: Feb. 7, 2024

Language: Английский

Citations

105
Dendritic cells as shepherds of T cell immunity in cancer DOI Open Access
Mikaël J. Pittet, Mauro Di Pilato, Christopher Garris

et al.

Immunity, Journal Year: 2023, Volume and Issue: 56(10), P. 2218 - 2230

Published: Sept. 13, 2023

Language: Английский

Citations

92
A distinct stimulatory cDC1 subpopulation amplifies CD8+ T cell responses in tumors for protective anti-cancer immunity DOI Creative Commons
Philippa Meiser, Moritz Knolle,

Anna Hirschberger

et al.

Cancer Cell, Journal Year: 2023, Volume and Issue: 41(8), P. 1498 - 1515.e10

Published: July 13, 2023

Type 1 conventional dendritic cells (cDC1) can support T cell responses within tumors but whether this determines protective versus ineffective anti-cancer immunity is poorly understood. Here, we use imaging-based deep learning to identify intratumoral cDC1-CD8+ clustering as a unique feature of immunity. These clusters form selectively in stromal tumor regions and constitute niches which cDC1 activate TCF1+ stem-like CD8+ cells. We distinct population immunostimulatory CCR7neg that produce CXCL9 promote cluster formation cross-present antigens these niches, required for differentiation expansion promotes cancer immune control. Similarly, human cancers, interact with are associated patient survival. Our findings reveal an phase the response orchestrated by tumor-residing could be exploited therapy.

Language: Английский

Citations

86
The hallmarks of cancer immune evasion DOI
Claudia Galassi, Timothy A. Chan, Ilio Vitale

et al.

Cancer Cell, Journal Year: 2024, Volume and Issue: 42(11), P. 1825 - 1863

Published: Oct. 10, 2024

Language: Английский

Citations

70
Ferroptosis in health and disease DOI Creative Commons
Carsten Berndt, Hamed Alborzinia,

Vera Skafar Amen

et al.

Redox Biology, Journal Year: 2024, Volume and Issue: 75, P. 103211 - 103211

Published: May 30, 2024

Ferroptosis is a pervasive non-apoptotic form of cell death highly relevant in various degenerative diseases and malignancies. The hallmark ferroptosis uncontrolled overwhelming peroxidation polyunsaturated fatty acids contained membrane phospholipids, which eventually leads to rupture the plasma membrane. unique that it essentially spontaneous, uncatalyzed chemical process based on perturbed iron redox homeostasis contributing process, but nonetheless modulated by many metabolic nodes impinge cells' susceptibility ferroptosis. Among affecting sensitivity, several have emerged as promising candidates for pharmacological intervention, rendering ferroptosis-related proteins attractive targets treatment numerous currently incurable diseases. Herein, current members Germany-wide research consortium focusing research, well key external experts who made seminal contributions this rapidly growing exciting field gathered provide comprehensive, state-of-the-art review Specific topics include: basic mechanisms, vivo relevance, specialized methodologies, tools, potential contribution disease etiopathology progression. We hope article will not only established scientists newcomers with an overview multiple facets ferroptosis, also encourage additional efforts characterize further molecular pathways modulating ultimate goal develop novel pharmacotherapies tackle associated - or caused

Language: Английский

Citations

69
Cancer cell metabolism and antitumour immunity DOI
Mara De Martino, Jeffrey C. Rathmell, Lorenzo Galluzzi

et al.

Nature reviews. Immunology, Journal Year: 2024, Volume and Issue: 24(9), P. 654 - 669

Published: April 22, 2024

Language: Английский

Citations

54
PGE2 limits effector expansion of tumour-infiltrating stem-like CD8+ T cells DOI Creative Commons

Sebastian Lacher,

Janina Dörr, Gustavo Pereira de Almeida

et al.

Nature, Journal Year: 2024, Volume and Issue: 629(8011), P. 417 - 425

Published: April 24, 2024

Abstract Cancer-specific TCF1 + stem-like CD8 T cells can drive protective anticancer immunity through expansion and effector cell differentiation 1–4 ; however, this response is dysfunctional in tumours. Current cancer immunotherapies 2,5–9 promote responses some but not all patients. This variation points towards currently ill-defined mechanisms that limit cell-mediated immunity. Here we demonstrate tumour-derived prostaglandin E2 (PGE 2 ) restricts the proliferative of within tumours, which promotes immune escape. PGE does affect priming draining lymph nodes. acts EP 4 (EP /EP receptor signalling to intratumoural generation early late populations originate from tumour-infiltrating lymphocytes (TILs). Ablation cancer-specific rescues their tumours leads tumour elimination multiple mouse models. Mechanistically, suppression interleukin-2 (IL-2) pathway underlies -mediated inhibition TIL responses. Altogether, uncover a key mechanism IL-2 responsiveness TILs prevents these cells. study identifies –EP axis as molecular target restore achieve control.

Language: Английский

Citations

44
Metabolic reprogramming in the tumor microenvironment of liver cancer DOI Creative Commons
Jian Lin, Dongning Rao, Mao Zhang

et al.

Journal of Hematology & Oncology, Journal Year: 2024, Volume and Issue: 17(1)

Published: Jan. 31, 2024

The liver is essential for metabolic homeostasis. onset of cancer often accompanied by dysregulated function, leading to rearrangements. Overwhelming evidence has illustrated that cellular metabolism can, in turn, promote anabolic growth and tumor propagation a hostile microenvironment. In addition supporting continuous survival, disrupted process also creates obstacles the anticancer immune response restrains durable clinical remission following immunotherapy. this review, we elucidate communication between cells their surrounding discuss how reprogramming impacts microenvironment efficacy We describe crucial role gut-liver axis remodeling crosstalk surveillance escape, highlighting novel therapeutic opportunities.

Language: Английский

Citations

41
Nanotechnology Reprogramming Metabolism for Enhanced Tumor Immunotherapy DOI

Yangkai Zhou,

Jing Yuan, Ke Xu

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(3), P. 1846 - 1864

Published: Jan. 5, 2024

Mutation burden, hypoxia, and immunoediting contribute to altered metabolic profiles in tumor cells, resulting a microenvironment (TME) characterized by accumulation of toxic metabolites depletion various nutrients, which significantly hinder the antitumor immunity via multiple mechanisms, hindering efficacy immunotherapies. In-depth investigation mechanisms underlying these phenomena are vital for developing effective drugs therapies, while therapeutic effects metabolism-targeting restricted off-target toxicity toward effector immune cells high dosage-mediated side effects. Nanotechnologies, exhibit versatility plasticity targeted delivery metabolism modulation, have been widely applied boost immunometabolic therapies strategies, including targeting pathways. In this review, recent advances understanding roles cell both immunoevasion immunosuppression reviewed, nanotechnology-based reprogramming strategies enhanced immunotherapies discussed.

Language: Английский

Citations

21