Immunoregulatory hydrogel decorated with Tannic acid/Ferric ion accelerates diabetic wound healing via regulating Macrophage polarization

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 466, P. 143173 - 143173

Published: April 24, 2023

Language: Английский

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Losartan attenuates sepsis-induced cardiomyopathy by regulating macrophage polarization via TLR4-mediated NF-κB and MAPK signaling

Pharmacological Research, Journal Year: 2022, Volume and Issue: 185, P. 106473 - 106473

Published: Sept. 28, 2022

Language: Английский

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The role of macrophages polarization in sepsis-induced acute lung injury

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Aug. 24, 2023

Sepsis presents as a severe infectious disease frequently documented in clinical settings. Characterized by its systemic inflammatory response syndrome, sepsis has the potential to trigger multi-organ dysfunction and can escalate becoming life-threatening. A common fallout from is acute lung injury (ALI), which often progresses respiratory distress syndrome (ARDS). Macrophages, due their significant role immune system, are receiving increased attention studies. Macrophage polarization process that hinges on an intricate regulatory network influenced myriad of signaling molecules, transcription factors, epigenetic modifications, metabolic reprogramming. In this review, our primary focus classically activated macrophages (M1-like) alternatively (M2-like) two paramount phenotypes instrumental sepsis’ host response. An imbalance between M1-like M2-like precipitate onset exacerbate progression sepsis. This review provides comprehensive understanding interplay macrophage sepsis-induced (SALI) elaborates intervention strategy centers around crucial polarization.

Language: Английский

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Immune dysregulation in sepsis: experiences, lessons and perspectives

Cell Death Discovery, Journal Year: 2023, Volume and Issue: 9(1)

Published: Dec. 19, 2023

Sepsis is a life-threatening organ dysfunction syndrome caused by dysregulated host responses to infection. Not only does sepsis pose serious hazard human health, but it also imposes substantial economic burden on the healthcare system. The cornerstones of current treatment for remain source control, fluid resuscitation, and rapid administration antibiotics, etc. To date, no drugs have been approved treating sepsis, most clinical trials potential therapies failed reduce mortality. immune response pathogen complex, resulting in innate adaptive that, if not promptly controlled, can lead excessive inflammation, immunosuppression, failure re-establish homeostasis. impaired patients with immunotherapy modulate causing inflammation or enhancing immunity suggest importance demonstrating individualized therapy. Here, we review where cell production, effector function, survival are directly affected during sepsis. In addition, discuss septic highlight need precise according stratification.

Language: Английский

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In Situ Sustained Macrophage-Targeted Nanomicelle–Hydrogel Microspheres for Inhibiting Osteoarthritis

Research, Journal Year: 2023, Volume and Issue: 6

Published: Jan. 1, 2023

There are still challenges in applying drug nanocarriers for situ sustained macrophage targeting and regulation, due to the rapid clearance of burst release vivo. Herein, a nanomicelle-hydrogel microsphere, characterized by its macrophage-targeted nanosized secondary structure that allows it accurately bind M1 macrophages through active endocytosis, is employed addresses insufficient osteoarthritis therapeutic efficacy caused nanocarriers. The 3-dimensional microsphere can prevent escape nanomicelle, thus keeping joints, while ligand-guided carry drugs target enter macrophages, via transition from hydrophobicity hydrophilicity nanomicelles under inflammatory stimulation inside macrophages. experiments show sustainably regulate more than 14 days attenuate local "cytokine storm" continuous apoptosis promotion polarization inhibition. This micro/nano-hydrogel system shows excellent ability macrophage, realizes improvement utilization thereby be potential platform treating macrophage-related diseases.

Language: Английский

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Advances in the study of macrophage polarization in inflammatory immune skin diseases

Journal of Inflammation, Journal Year: 2023, Volume and Issue: 20(1)

Published: Oct. 12, 2023

Abstract When exposed to various microenvironmental stimuli, macrophages are highly plastic and primarily polarized into the pro-inflammatory M1-type anti-inflammatory M2-type, both of which perform almost entirely opposing functions. Due this characteristic, different functions at stages immunity inflammation. Inflammatory immune skin diseases usually show an imbalance in M1/M2 macrophage ratio, altering polarization phenotype can either make symptoms worse or better. Therefore, review presents mechanisms polarization, inflammation-related signaling pathways (JAK/STAT, NF-κB, PI3K/Akt), role inflammatory (psoriasis, AD, SLE, BD, etc.) provide new directions for basic clinical research related diseases.

Language: Английский

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Epigenetic mechanisms of Immune remodeling in sepsis: targeting histone modification

Cell Death and Disease, Journal Year: 2023, Volume and Issue: 14(2)

Published: Feb. 11, 2023

Abstract Sepsis is a life-threatening disorder disease defined as infection-induced dysregulated immune responses and multiple organ dysfunction. The imbalance between hyperinflammation immunosuppression crucial feature of sepsis immunity. Epigenetic modifications, including histone DNA methylation, chromatin remodeling, non-coding RNA, play essential roles in regulating immunity through epi-information independent the sequence. In recent years, mechanisms modification have received increasing attention, with ongoing discoveries novel types modifications. Due to capacity for prolonged effects on cells, modifications can induce cell reprogramming participate long-term immunosuppressed state sepsis. Herein, we systematically review current involved regulation sepsis, summarize their role from an perspective provide potential therapeutic opportunities targeting treatment.

Language: Английский

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The role of IL-10 in kidney disease

International Immunopharmacology, Journal Year: 2022, Volume and Issue: 108, P. 108917 - 108917

Published: June 3, 2022

Kidney disease is a global health problem with high mortality and socioeconomic burden, including acute kidney injury (AKI), chronic (CKD), diabetic nephropathy (DN),and lupus nephritis (LN). However, IL-10 an anti-inflammatory factor. During severe infection in disease, maintaining tissue homeostasis by inhibiting excessive inflammatory response, regulating immune suppression, delaying fibrosis, promoting repair. Therefore, improving the pathogenesis identifying effective therapeutic targets are significant for treating diagnosing diseases. Thus, current review describes structure function of family focuses on crucial role disease. We further discuss regulatory mechanisms through which involved progression.

Language: Английский

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Rgl-exomiR-7972, a novel plant exosomal microRNA derived from fresh Rehmanniae Radix, ameliorated lipopolysaccharide-induced acute lung injury and gut dysbiosis

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 165, P. 115007 - 115007

Published: June 15, 2023

Plant-derived exosome-like nanoparticles (ELNs) have been proposed as a novel therapeutic tool for preventing human diseases. However, the number of well-verified plant ELNs remains limited. In this study, microRNAs in derived from fresh Rehmanniae Radix, well-known traditional Chinese herb treating inflammatory and metabolic diseases, were determined by using microRNA sequencing to investigate active components protection against lipopolysaccharide (LPS)-induced acute lung inflammation vivo vitro. The results showed that rgl-miR-7972 (miR-7972) was main ingredient ELNs. It exerted stronger protective activities LPS-induced than catalpol acteoside, which are two chemical markers herb. Moreover, miR-7972 decreased production pro-inflammatory cytokines (IL-1β, IL-6, TNF-α), reactive oxygen species (ROS) nitric oxide (NO) LPS-exposed RAW264.7 cells, thereby facilitating M2 macrophage polarization. Mechanically, downregulated expression G protein-coupled receptor 161 (GPR161), activating Hedgehog pathway, inhibited biofilm form Escherichia coli via targeting virulence gene sxt2. Therefore, R. Radix alleviated GPR161-mediated recovering gut microbiota dysbiosis. also provided new direction gaining bioactivity nucleic acid drugs broadening knowledge on cross-kingdom physiological regulation through miRNAs.

Language: Английский

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Cell-membrane-coated nanoparticles for the fight against pathogenic bacteria, toxins, and inflammatory cytokines associated with sepsis

Theranostics, Journal Year: 2023, Volume and Issue: 13(10), P. 3224 - 3244

Published: Jan. 1, 2023

Sepsis is the main cause of death in patients suffering from serious illness.Yet, there still no specific treatment for sepsis, and management relies on infection control.Cell membrane-coated nanoparticles (MNPs) are a new class biomimetic based covering surface synthetic (NPs) with natural cell membranes.They retain physicochemical properties nanomaterials inherit cellular membranes, showing excellent biological compatibility, enhanced biointerfacing capabilities, capacity to hold functions characteristics, immunological escape, longer half-life when circulation.Additionally, they prevent decomposition encapsulated drug active targeting.Over years, studies MNPs have multiplied breakthrough has been achieved cancer therapy.Nevertheless, use "bio"-related approaches rare treating sepsis.Herein, we discussed current state-of-the-art bacterial sepsis by combining pathophysiology therapeutic benefits i.e., pathogenic bacteria, bacteria-producing toxins, inflammatory cytokines produced dysregulated response associated sepsis.

Language: Английский

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