The role of macrophages polarization in sepsis-induced acute lung injury

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Aug. 24, 2023

Sepsis presents as a severe infectious disease frequently documented in clinical settings. Characterized by its systemic inflammatory response syndrome, sepsis has the potential to trigger multi-organ dysfunction and can escalate becoming life-threatening. A common fallout from is acute lung injury (ALI), which often progresses respiratory distress syndrome (ARDS). Macrophages, due their significant role immune system, are receiving increased attention studies. Macrophage polarization process that hinges on an intricate regulatory network influenced myriad of signaling molecules, transcription factors, epigenetic modifications, metabolic reprogramming. In this review, our primary focus classically activated macrophages (M1-like) alternatively (M2-like) two paramount phenotypes instrumental sepsis’ host response. An imbalance between M1-like M2-like precipitate onset exacerbate progression sepsis. This review provides comprehensive understanding interplay macrophage sepsis-induced (SALI) elaborates intervention strategy centers around crucial polarization.

Language: Английский

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CD147 Sparks Atherosclerosis by Driving M1 Phenotype and Impairing Efferocytosis

Circulation Research, Journal Year: 2024, Volume and Issue: 134(2), P. 165 - 185

Published: Jan. 3, 2024

Atherosclerosis is a globally prevalent chronic inflammatory disease with high morbidity and mortality. The development of atherosclerotic lesions determined by macrophages. This study aimed to investigate the specific role myeloid-derived CD147 (cluster differentiation 147) in atherosclerosis its translational significance.

Language: Английский

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Toll‐like receptors in health and disease

MedComm, Journal Year: 2024, Volume and Issue: 5(5)

Published: April 29, 2024

Toll-like receptors (TLRs) are inflammatory triggers and belong to a family of pattern recognition (PRRs) that central the regulation host protective adaptive immune responses. Activation TLRs in innate myeloid cells directs lymphocytes produce most appropriate effector responses eliminate infection maintain homeostasis body's internal environment. Inappropriate TLR stimulation can lead development general autoimmune diseases as well chronic acute inflammation, even cancer. Therefore, expected be targets for therapeutic treatment inflammation-related diseases, microbial infections, human cancers. This review summarizes recent discoveries molecular structural biology TLRs. The role different signaling pathways such diabetes, cardiovascular respiratory digestive cancers (oral, gastric, breast, colorectal) is highlighted new drugs related clinical treatments trials, providing an overview potential prospects TLR-related diseases.

Language: Английский

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Cardiovascular disease: Mitochondrial dynamics and mitophagy crosstalk mechanisms with novel programmed cell death and macrophage polarisation

Pharmacological Research, Journal Year: 2024, Volume and Issue: 206, P. 107258 - 107258

Published: June 21, 2024

Several cardiovascular illnesses are associated with aberrant activation of cellular pyroptosis, ferroptosis, necroptosis, cuproptosis, disulfidptosis and macrophage polarisation as hallmarks contributing to vascular damage abnormal cardiac function. Meanwhile, these three novel forms dysfunction closely related mitochondrial homeostasis. Mitochondria the main organelles that supply energy maintain Mitochondrial stability is maintained through a series regulatory pathways, such fission, fusion mitophagy. Studies have shown (e.g., impaired dynamics mitophagy) promotes ROS production, leading oxidative stress, which induces M1 phenotypic polarisation. Therefore, an in-depth knowledge dynamic regulation mitochondria during necessary understand disease development. This paper systematically summarises impact changes in mitophagy on regulating dysfunctions promote understanding pathogenesis diseases provide corresponding theoretical references for treating diseases.

Language: Английский

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Angiotensin-(1–7) ameliorates sepsis-induced cardiomyopathy by alleviating inflammatory response and mitochondrial damage through the NF-κB and MAPK pathways

Journal of Translational Medicine, Journal Year: 2023, Volume and Issue: 21(1)

Published: Jan. 2, 2023

Abstract Background There is no available viable treatment for Sepsis-Induced Cardiomyopathy (SIC), a common sepsis complication with higher fatality risk. The septic patients showed an abnormal activation of the renin angiotensin (Ang) aldosterone system (RAAS). However, it not known how Ang II and Ang-(1–7) affect SIC. Methods Peripheral plasma was collected from Healthy Control (HC) protein concentrations were measured. in vitro vivo models SIC developed using Lipopolysaccharide (LPS) to preliminarily explore relationship between state, II, levels, along protective function exogenous on Results II/Ang-(1–7) levels SIC-affected elevated compared HC non-SIC patients, however, levels. Furthermore, peripheral II/Ang-(1–7), significantly correlated degree myocardial injury. Additionally, can attenuate inflammatory response, reduce oxidative stress, maintain mitochondrial dynamics homeostasis, alleviate structural functional damage by inhibiting nuclear factor-kappa B (NF-κB) mitogen-activated kinase (MAPK) signaling pathways, thus alleviating Conclusions Plasma Ang-(1–7), regarded as significant biomarkers. In SIC, therapeutic targeting RAAS, example may exert roles against damage.

Language: Английский

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Syzygium aromaticum enhances innate immunity by triggering macrophage M1 polarization and alleviates Helicobacter pylori-induced inflammation

Journal of Functional Foods, Journal Year: 2023, Volume and Issue: 107, P. 105626 - 105626

Published: June 21, 2023

Previous studies suggested that Syzygium aromaticum dried buds (S. aromaticum), which is an edible and medicinal herb, possess potential effect on innate immunity Helicobacter pylori (H. pylori) infection-related inflammation, but the specific action especially molecular mechanism have not been well elucidated. The objective of this work was to further explore effects aqueous extract (AE) H. related-inflammation, mechanisms involved. In order accomplish this, analyses phagocytic rate, NO content, ROS level, as ELISA, RT-qPCR, Western blotting et al. assays were carried out. Results indicated AE increased ROS, cytokine expression levels, meanwhile activated TLR4/MyD88 mediated NF-κB MAPK pathways decreased Nrf2/HO-1 signaling. also prevented release pro-inflammatory substances made by pylori-infected RAW 264.7 GES-1 cells. All things considered, it shown AE's ability boost involves inducing macrophage M1 polarization increasing TLR4/MyD88-mediated blocking Additionally, lowering production molecules, can lessen inflammation brought pylori. Considering S. herbal medicine with immune-enhancing activity good safety, deserves study utilization for treating diseases including disorders.

Language: Английский

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Fe-Capsaicin Nanozymes Attenuate Sepsis-Induced Acute Lung Injury via NF-κB Signaling

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 73 - 90

Published: Jan. 1, 2024

Background: In sepsis, the lungs are one of most severely affected organs, usually resulting in acute lung injury (ALI). Capsaicin (CAP) is a natural compound found chili peppers that has pain-relieving and anti-inflammatory properties. Here, we report nanoparticles containing capsaicin iron (Fe-CAP NPs) exhibited effects treatment ALI. Methods: The morphological characteristics nanozymes were detected. RAW 264.7 cells divided into four groups: control, lipopolysaccharide (LPS), CAP+LPS Fe-CAP+LPS groups. expression inducible nitric oxide synthase (iNOS), transforming growth factor-β (TGF-β), tumor necrosis factor-α (TNF-α) was assessed by immunofluorescence, Western blot, enzyme-linked immunosorbent assay (ELISA). Nuclear factor kappa-B (NF-κB) determined blot. C57 mice LPS, Interleukin-6 (IL-6) iNOS detected Blot. IL-6 TNF-α serum ELISA. Extravasated Evans blue, histopathological evaluation wet-to-dry (W/D) weight ratio used to assess pulmonary capillary permeability. blood major organs (heart, liver, spleen, kidney) tested for toxicity Fe-CAP NPs. Results: LPS group, TNF-α, iNOS, p-NF-κB p-IKBα increased. However, their significantly decreased group. TGF-β showed opposite trend. vivo, notably increased group but with pretreatment. ameliorated EB leakage, improved histopathology tissue reduced W/D ratio. non-cytotoxicity, when studying these biological activities. Conclusion: NPs could alleviated inflammation inhibiting pro-inflammatory factors macrophages, increasing factors, alleviating damage. Keywords: capsaicin, macrophage, nanoparticles,

Language: Английский

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IL-27 regulates macrophage ferroptosis by inhibiting the Nrf2/HO1 signaling pathway in sepsis-induced ARDS

Inflammation Research, Journal Year: 2025, Volume and Issue: 74(1)

Published: Feb. 13, 2025

Language: Английский

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Role of Angiotensin II in Cardiovascular Diseases: Introducing Bisartans as a Novel Therapy for Coronavirus 2019

Biomolecules, Journal Year: 2023, Volume and Issue: 13(5), P. 787 - 787

Published: May 2, 2023

Cardiovascular diseases (CVDs) are the main contributors to global morbidity and mortality. Major pathogenic phenotypes of CVDs include development endothelial dysfunction, oxidative stress, hyper-inflammatory responses. These have been found overlap with pathophysiological complications coronavirus disease 2019 (COVID-19). identified as major risk factors for severe fatal COVID-19 states. The renin–angiotensin system (RAS) is an important regulatory in cardiovascular homeostasis. However, its dysregulation observed CVDs, where upregulation angiotensin type 1 receptor (AT1R) signaling via II (AngII) leads AngII-dependent CVDs. Additionally, interaction between spike protein acute respiratory syndrome 2 angiotensin-converting enzyme downregulation latter, resulting RAS. This favors AngII/AT1R toxic pathways, providing a mechanical link pathology COVID-19. Therefore, inhibiting through blockers (ARBs) has indicated promising therapeutic approach treatment Herein, we review role AngII We also provide future direction potential implication novel class ARBs called bisartans, which speculated contain multifunctional targeting towards

Language: Английский

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Macrophage-related therapeutic strategies: Regulation of phenotypic switching and construction of drug delivery systems

Pharmacological Research, Journal Year: 2023, Volume and Issue: 199, P. 107022 - 107022

Published: Dec. 1, 2023

Macrophages, as highly phenotypic plastic immune cells, play diverse roles in different pathological conditions. Changing and controlling the phenotypes of macrophages is considered a novel potential therapeutic intervention. Meanwhile, specific transmembrane proteins anchoring on surface macrophage membrane are relatively conserved, supporting its functional properties, such inflammatory chemotaxis tumor targeting. Thus, series drug delivery systems related to commonly used treat chronic diseases. This review summarizes macrophages-based strategies for diseases, discusses regulation their polarization processes, presents how design apply site-specific targeted vivo based derived receptors. It aims provide better understanding immunoregulation proposes approaches

Language: Английский

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